Shu-Ling Chiu's Lab
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Shu-Ling Chiu
Assistant Research Fellow- SpecialtySynaptic Plasticity, Neural Development, Learning and Memory
- E-mailslchiu@gate.sinica.edu.tw
- Tel02-2789-9536
- LabR510/ICOB
Our laboratory has broad interests in the Molecular & Cellular basis of Learning and Memory. Utilizing multidisciplined approaches including electrophysiology, biochemical, cellular biology, live-imaging, genetic methods and animal behaviors in mice and primary cultures, we aim to understand how brain cells develop and integrate into distinct circuits for proper brain function. We are particular interested in the following research areas:
1) How neuronal connectivity is established to assemble functioning brain circuits during development
2) How synaptic plasticity affects learning and memory
3) How synaptic dysfunction contributes to neurodevelopmental disorders (e.g. intellectually disability and autism spectrum disorder)
Over the years, we and our colaborators have made signiciant progress in better understanding mechanisms that regulate cognitive brain funtion from synapse, neuron to circuit levels. Our major areas of contributions with representative publications are listed as the following:
- Tan HL*, Chiu S-L*, Zhu Q*, and Huganir RL. 2020. GRIP1 regulates synaptic plasticity and learning and memory. Proc Natl Acad Sci USA 117(40): 25085-25091 (*: Equal contribution)
- Chiu S-L, Diering G, Ye B, Takamiya K, Jiang Y, Niranjan T, Schwartz CE, Wang T and Huganir RL. 2017 GRASP1 regulates synaptic plasticity and memory through endosomal recycling of AMPA receptors. Neuron 93(6): 1405-1419
- Gu Y, Chiu S-L, Liu B, Wu PH, Delannoy M, Lin DT, Wirtz D and Huganir RL. 2016 Differential vesicular sorting of AMPA and GABAA receptors. Proc Natl Acad Sci USA 113 (7): E922-31
- Chen C-M, Orefice L*, Chiu S-L*, LeGates T, Hattar S, Huganir RL, Zhao H, Xu B and Kuruvilla R. 2017, Wnt5a is essential for hippocampal dendritic maintenance and spatial learning and memory in adult mice. Proc Natl Acad Sci USA, 114(4): E619-E628.
- Chiu S-L, Chen CM, Cline HT. 2008. Insulin receptor signaling regulates synapse number, dendritic plasticity and circuit function in vivo. Neuron 58(5): 708-719
- Mejias R, Chiu S-L, Han M, Rose R, Gil-Infante A, Zhao Y, Huganir RL, Wang T. 2019 Purkinje cellspecific Grip1/2 knockout mice show increased repetitive self-grooming and enhanced mGluR5 signaling in cerebellum. Neurobiol Dis. 132:104602
- Volk L, Chiu S-L, Sharma K, Huganir RL. 2015 Glutamate synapses in human cognitive disorders. Annual Review of Neuroscience 38(1): 127-49
We believe that our goal of pursuing an in-depth understanding of the molecular & cellular basis of synaptic function will not only refine our understanding of the mechanisms regulating synaptic plasticity, neuronal structure and learning & memory. Further, they will also lend insight into the pathophysiology of neurodevelopmental diseases, which has great potential for the development of novel therapeutic treatments to ameliorate these disorders.