研究人員｜中央研究院 細胞與個體生物學研究所

• 2022   Career Development Award, Academia Sinica, Taiwan (中研院前瞻研究計畫)
• 2021   Excellent Young Scholar Award, Ministry of Science & Technology, Taiwan (科技部2030跨世代年輕學者方案 - 優秀年輕學者獎)
• 2018   Young Investigator and Travel Award, SYNGAP1/Neurodevelopmental Disorder Therapies Meeting (NINDS-sponsored), Florida, USA
• 2016   Young Investigator and Travel Award, The International SYNGAP Conference (NINDS-sponsored), Texas, US
• 2012  NARSAD Young Investigator Grant, Brain & Behavior Research Foundation, USA

Research Articles

1. Han M, Tan HL, Mejías R, Chiu S-L, Kim J, Huganir RL, and Wang T. 2026. Dysregulated GluA2-Y876 phosphorylation contributes to loss of synaptic upscaling in GRIP1 mutant mice with reduced sociability and increased repetitive behavior. Mol Psychiatry 31, 2764–2777
2. Chen C-M, Huang Y-M, Chung C-C, Johnson RC, Tsai C-Y, Chen Y-H, Tan HL, Hsiao F-Y, Huganir RL^#, Chiu S-L^#. 2025. Rescuing neurodevelopmental deficits in AMPA receptor gain-of-function mutant. BioRxiv
3. Chen C-M, Wu C-C, Kim Y, Hsu W-Y, Tsai Y-C^#, Chiu S-L^#. 2024 Enhancing social behavior in an autism spectrum disorder mouse model: investigating the underlying mechanims of Lactiplantibacillus plantarum interventions. Gut Microbes 16(1): 2359501 (^# Correspondence)
4. Chiu S-L*^#, Chen C-M*, and Huganir RL^#. 2023 ICA69 regulates activity-dependent synaptic strengthening and learning and memory. Front. Molecular Neuroscience (*: Equal contribution, ^# Correspondence)
5. Tan HL*, Chiu S-L*, Zhu Q*, and Huganir RL. 2020. GRIP1 regulates synaptic plasticity and learning and memory. PNAS 117(40): 25085-25091 (*: Equal contribution) 
6. Mejias R, Chiu S-L, Han M, Rose R, Gil-Infante A, Zhao Y, Huganir RL, Wang T. 2019 Purkinje cell-specific Grip1/2 knockout mice show increased repetitive self-grooming and enhanced mGluR5 signaling in cerebellum. Neurobiol Dis. 132:104602
7. Wang Q, Chiu S-L*, Koropouli E*, Hong I*, Mitchell S, Easwaran TP, Hamilton N, Gustina A, Zhu Q, Ginty DD, Huganir RL, Kolodkin AL. 2017 Neuropilin-2/PlexinA3 receptors associate with GluA1 and mediate Sema3F-dependent homeostatic scaling in cortical neurons. Neuron 96(5): 1084-1098 (*: Equal contribution)
8. Chiu S-L, Diering G, Ye B, Takamiya K, Jiang Y, Niranjan T, Schwartz CE, Wang T and Huganir RL. 2017 GRASP1 regulates synaptic plasticity and memory through endosomal recycling of AMPA receptors. Neuron 93(6): 1405-1419
9. Han M, Mejias R, Chiu S-L, Rose R, Adamczyk, A, Huganir RL and Wang T. 2017 Mice lacking GRIP1/2 show increased social interactions and enhanced phosphorylations at GluA2-S880. Behavioural Brain Research 321: 176-84
10. Chen C-M, Orefice L*, Chiu S-L*, LeGates T, Hattar S, Huganir RL, Zhao H, Xu B and Kuruvilla R. 2017 Wnt5a is essential for hippocampal dendritic maintenance and spatial learning and memory in adult mice. PNAS 114(4): E619-28 (*: Equal contribution)
11. Gu Y, Chiu S-L, Liu B, Wu PH, Delannoy M, Lin DT, Wirtz D and Huganir RL. 2016 Differential vesicular sorting of AMPA and GABA_A receptors. PNAS 113 (7): E922-31
12. Zhang K, Donnelly CJ, Haeusler AR, Grima JC, Machamer JB, Steinwald P, Daley EL, Miller SJ, Cunningham KM, Vidensky S, Gupta S, Thomas MA, Hong I, Chiu S-L, Huganir RL, Ostrow LW, Matunis MJ, Wang J, Sattler R, Lloyd TE, Rothstein JD. 2015 The C9orf72 repeat expansion disrupts nucleocytoplasmic transport. Nature 525(7567): 56-61
13. Thomas GM, Hayashi T, Chiu S-L, Chen CM and Huganir RL. 2012 Palmitoylation by DHHC5/8 targets GRIP to dendritic endosomes to regulate AMPA-R trafficking. Neuron 73(3): 482-96
14. Li J, Wang Y, Chiu S-L, Cline HT. 2010. Membrane targeted horseradish peroxidase as a marker for correlative fluorescence and electron microscopy studies. Front. Neural Circuits 26(4): 6
15. Chen C-M*, Chiu S-L*, Cline HT. 2009. Co-expression of Argonaute2 enhances short hairpin RNA-induced RNA interference in Xenopus CNS neurons in vivo. Front. Neuroscience 9(3):63. ( *: Equal contribution)
16. Chiu S-L, Chen CM, Cline HT. 2008. Insulin receptor signaling regulates synapse number, dendritic plasticity and circuit function in vivo. Neuron 58(5): 708-719
17. Bestman JE*, Ewald RC*, Chiu S-L*, Cline HT. 2006. In vivo single-cell electroporation for transfer of DNA and macromolecules. Nature Protocols 1(3): 1267-1272 ( *: Equal contribution)
18. Chiang A-S, Lin W-Y, Liu H-P, Pszczolkowski MA, Fu T-F, Chiu S-L, Holbrook GL. 2002. Insect NMDA receptors mediate juvenile hormone biosynthesis. PNAS 99(1): 37-44
19. Chiang A-S, Liu Y-C, Chiu S-L, Hu S-H, Huang C-Y, Hsieh C-H. 2001. Three-dimensional mapping of brain neuropils in the cockroach, Diploptera punctata. J. Comp. Neurol. 440: 1-11

Review Articles

1. Volk L, Chiu S-L, Sharma K, Huganir RL. 2015. Glutamate synapses in human cognitive disorders. Annual Review of Neuroscience 38(1): 127-49

2. Chiu S-L and Cline HT. 2010. Insulin receptor signaling in the development of neuronal structure and function. Neural Development 5(7)