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Monoubiquitylation of histone H2B contributes to the bypass of DNA damage during and after DNA replication

Proc Natl Acad Sci U S A. 2017 Feb 28. pii: 201612633. doi: 10.1073/pnas.1612633114.
http://www.pnas.org/content/early/2017/02/27/1612633114.long
 

DNA damage bypass mechanisms that facilitate the resolution of replication blocks in proliferating cells during and after S phase are important for the defense against damage-induced mutations, genome instability and cancer. Lesion bypass, mediated either by the ubiquitylation of the replication factor PCNA or by homologous recombination, takes place in the context of chromatin. However, the implications of nucleosome dynamics and chromosome packaging on the efficiency of replication-associated damage processing are still largely unknown. Our physical, genetic, and cytological studies now suggest that ubiquitylation of histone H2B facilitates the replicative bypass of fork-stalling DNA lesions by contributing to both DNA damage tolerance and homologous recombination during and after replication; thus revealing a direct link between chromatin architecture and lesion bypass.
 


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115台北市南港區研究院路二段128號
Tel: 02-27899515
Fax: 02-27858059
icob@gate.sinica.edu.tw
Copyright © ICOB 2013. All rights reserved. 最佳瀏覽網頁方式請用最新版IE11或其他瀏覽器 /瀏覽人數:942603--
 瀏覽人數:942603