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姓名:黃鵬鵬

職稱:特聘研究員 兼代理所長

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專長:Fish Molecular Physiology

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研究人員 / 簡介

  2016.06- Acting Director, Inst. of Cellular and Organismic Biology, Academia Sinica
  2011- Adjunct Professor, Inst. of Life Science, National Taiwan University
  2008- Distinguished Research Fellow, Inst. of Cellular and Organismic Biology, Academia Sinica
  2001-2016.05 Vice Director, Inst. of Zoology/ Cellular and Organismic Biology, Academia Sinica
  1991- Adjunct Prof. Institute of Fisheries Science, National Taiwan Univ., Taiwan
  1990-1991, Visiting Research Fellow, Dept. of Cellular & Molecular Physiology, Harvard Medical School
  1989- Research Fellow, Inst. of Zoology/ Cellular and Organismic Biology, Academia Sinica
  1984-1989, Associate Research Fellow, Inst. of Zoology, Academia Sinica
  1984, Ph.D. Dept. of Fisheries, University of Tokyo, Japan

黃鵬鵬 老師 實驗室

  • 我們致力於魚類離子和滲透壓調節機制的探討,對於魚類體液離子與酸鹼平衡調控的分子/細胞機轉,以及面對環境變動時內分泌系統對體液恆定的調控作用尤感興趣。近年來,我們利用多種分子生理學和功能性基因體學的研究方法,以斑馬魚、青鏘魚等為實驗對象進行一系列研究,建立起魚類離子調節研究的新平台,並開啟相關議題未來發展的新方向,為當前相關領域提供嶄新的觀點。 研究主題包括: 1.魚類離子調節機制的新模式; 2.離子細胞增生、分化及功能調節; 3.離子調節機制的內分泌調控; 4.海洋椎動物面對氣候變遷的生理機制。

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    黃鵬鵬特聘研究員 兼代理所長
  • Selected publications

    1. Wu, S. C., J. L. Horng, S. T. Liu, P. P. Hwang, Z. H. Wen, C. S. Lin and L. Y. Lin (2010) Ammonium-dependent sodium uptake in mitochondrion-rich cells of medaka (Oryzias latipes) larvae. Am. J. Physiol. Cell Physiogy. 298: C237-250. (selected as an Editorial Focus)
    2. Hwang P. P.,* T. H. Lee and L. Y. Lin (2011) Ion regulation in fish gills: recent progresses in the cellular and molecular mechanisms. Am. J. Physiol. Comparative/Integrative Physiology. 301: R28-R47. (Invited Review Article).
    3. Lafont, A. G., Y. F. Wang, G. D. Chen, B. K. Liao, Y. C. Tseng, C. J. Huang and P. P. Hwang*. (2011) Involvement of calcitonin and its receptor in the control of calcium regulating-genes and calcium homeostasis in zebrafish (Danio rerio). J. Bone Miner. Res. 26: 1072-1083.
    4. Chou, M. Y., J. C. Hung, L. C. Wu, S. P. L. Hwang and P. P. Hwang*. (2011) Isotocin controls ion regulation through regulating ionocyte progenitor differentiation and proliferation. Cell Mol. Life Sci. 68: 2797-2809.
    5. Chang, W. J. and P. P. Hwang* (2011) Development of zebrafish epidermis. Birth Defects Res. C. 93: 205-214. (Invited Review Article).
    6. Lin, C. C., L. Y. Lin, H. H. Hsu, V. Thermes, P. Prunet, J. L. Horng and P. P. Hwang* (2012) Acid secretion by mitochondrion-rich cells of medaka (Oryzias latipes) acclimated to acidic fresh water. Am. J. Physiol. Comparative/Integrative Physiology. 302: R283-R291. (Cover Image)
    7. Dymowska, A., P. P. Hwang and G. G. Goss (2012) Structure and function of ionocytes in the freshwater fish gill. Resp. Physiol. Neurobiol. 184: 282-292. (Invited Review Article)
    8. Hwang, P. P*. and M. Y. Chou (2013) Zebrafish as an animal model to study ion homeostasis. Pflugers Arch - Eur J Physiol. 465: 1233-1247. (Invited Review Article)
    9. Chang, W. J., F. F. Wang, H. J. Hu, J. H. Wang T. H. Lee and P. P. Hwang* (2013) Compensatory regulation of Na+ absorption by Na+/H+ exchanger and Na+-Cl- cotransporter in zebrafish (Danio rerio). Front. Zool. 10:46.
    10. Lin, C. H., C. H. Su, and P. P. Hwang* (2014) Calcium-sensing receptor mediates Ca2+ homeostasis by modulating expression of PTH and stanniocalcin. Endocrinol. 155: 56-67.
    11. Guh, Y. J., Y. C. Tseng, C. Y. Yang and P. P. Hwang* (2014) Endothelin-1 regulates H+-ATPase-dependent transepithelial H+ secretion in zebrafish. Endorcinol. 155: 1728-1737.
    12. Tseng, Y. C., S. T. Liu, M. Y. Hu, R. D. Cheng, J. R. Lee and P. P. Hwang* (2014) Brain functioning under acute hypothermic stress supported by dynamic monocarboxylate utilization and transport in ectothermic fish. Front. Zool. 11:53.
    13. Hu, M. Y., Y. J. Guh, M. Stumpp, J, R, Lee, R. D. Chen, P. H. Sung, Y. C. Chen, P. P. Hwang and Y. C. Tseng* (2014) Branchial NH4+-dependent acid–base transport mechanisms and energy metabolism of squid (Sepioteuthis lessoniana) affected by seawater acidification. Front. Zool. 11:55
    14. Chou, M. Y., P. L. Chao, J. C. Hung, S. A. Cruz and P. P. Hwang* (2015) Stanniocalcin-1 controls ion regulation functions of ion-transporting epithelium other than calcium balance. Int. J. Biol. Sci. 11: 122-132.
    15. Furukawa, F., Y. C. Tseng, S. T. Liu, Y. L. Chou, C. C. Lin, P. H. Sung, K. Uchida, L. Y. Lin and P. P. Hwang* (2015) Induction of phosphoenolpyruvate carboxykinase (PEPCK) during acute acidosis and its role in acid secretion by V-ATPase-expressing ionocytes. Int. J. Biol. Sci. 11: 712-725.
    16. Guh, Y. J., C. H. Lin and P. P. Hwang* (2015) Osmoregulation in zebrafish: ion transport mechanisms and functional regulation. EXCLI J. 14: 627-659. (Invited review article)
    17. Stumpp, M., M. Y. Hu, Y. C. Tseng, Y. J. Guh, Y. C. Chen, J. K. Yu, Y. H. Su and P. P. Hwang* (2015) Evolution of extreme stomach pH in bilateria inferred from gastric alkalization mechanisms in basal deuterostomes. Sci. Rep. 5:10421
    18. Hu, M. Y., P. P. Hwang* and Y. C. Tseng* (2015) Recent advances in understanding trans-epithelial acid-base regulation and excretion mechanisms in cephalopods. Tissue Barriers 3: e10641 (Invited review article)
    19. Wang, Y. F., J. J. Yan, Y. C. Che, R. D. Chen and P. P. Hwang*. (2015) Molecular physiology of an extra-renal Cl- uptake mechanism for body fluid Cl- homeostasis. Int. J. Biol. Sci. 11:1190-1203.
    20. Lin, C. H., T, H Shih, S. T. Liu, H. H. Hsu and P. P. Hwang* (2015) Cortisol regulates acid secretion of H+-ATPase-rich ionocytes in zebrafish (Danio rerio) larvae. Front. Physiol. 6: 328.
    21. Guh, Y. J., C. Y. Yang, S. T, Liu, C. J. Huang and P. P. Hwang* (2016) Estrogen-related receptor α is required for transepithelial H+ secretion in zebrafish. Proc. Biol. Sci. 283: 20152582.
    22. Wang, Y. F., A. G. Lafont, Y. C. Lee and P. P. Hwang* (2016) A novel function of calcitonin gene-related peptide in body fluid Cl- homeostasis. Proc. Biol. Sci. 283: 20160684
    23. Liu, S. T., J. L. Horng, P. Y. Chen, P. P. Hwang* and L. Y. Lin* (2016) Salt secretion is linked to acid-base regulation of ionocyte in seawater acclimated medaka: new insights into the salt secreting mechanism. Sci. Rep. 6:31433.
    24. Guh, Y. J, and P. P. Hwang* (2016) Insights into Mmolecular and cellular mechanisms of hormonal actions on fish ion regulation: derived from the zebrafish as a model. Gen. Comp. Endocrinol. (accepted) (Invited Review Article)

    Book Chapters

    1. Hwang, P. P. (2011) Mechanisms of Ion transport in Freshwater fishes. In: Farrell T,  Stevens D, Cech J, Richards J (eds) Encyclopedia of Fish Physiology: from genome to environment. pp 1359-1365. San Diego: Elsevier Academia Press.
    2. Hwang P. P.,* and L. Y. Lin (2014) Gill ion transport, acid-base regulation and nitrogen excretion. In: Evans D, Claiborne JB and Currie S (eds.) The Physiology of Fishes, 4th Edition. pp 205-233. Boca Raton: CRC Press.
    3. Takei, Y and P. P. Hwang (2016) Homeostatic Responses to Osmotic Stress. In: Schreck C, Tort L (eds.) Fish Physiology-Biology of Stress in Fish. vol 35., San Diego: Elsevier Academia Press (in press)

    Link to the complete list of publications

     


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    115台北市南港區研究院路二段128號
    Tel: 02-27899515
    Fax: 02-27858059
    icob@gate.sinica.edu.tw
    Copyright © ICOB 2013. All rights reserved. 最佳瀏覽網頁方式請用最新版IE11或其他瀏覽器 /瀏覽人數:942600--
     瀏覽人數:942600