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姓名:易玲輝

職稱:副研究員

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專長:Cell Biology,
Genetic Toxicology

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研究人員 / 簡介
  2001-2002, Assistant Professor, Institute of Pharmacology and Toxicology, Tzu Chi Univ, Taiwan
  1998-2001, Postdoctoral Fellow, Institute of Biomedical Sciences, Academia Sinica, Taiwan
  1998, Ph.D. Institute of Life Sciences, National Defense Medical Center, Taiwan

易玲輝 老師 實驗室

  •  有絲分裂期細胞崩猝是一種細胞於有絲分裂期死亡的形式,通常導因於DNA損傷的誘發或有絲分裂的異常,目前被認為是許多抗癌藥物達到療效的主要機制。另一方面,遺傳不穩定性是腫瘤細胞的特徵之一,其誘發也是導致細胞癌化的重要原因。核酸、染色體、及控制染色體分離的系統是許多致癌劑所攻擊的標的;而核酸損傷或染色體異常的誘發或干擾染色體分離常會導致遺傳不穩定性的發生。因此,在有絲分裂異常的細胞中,若細胞崩猝無法被適當的誘發,不正常的分裂將有可能導致子細胞發生遺傳不穩定性。利用會造成DNA或紡錘體損傷的化合物,我們在細胞的層次探討這些損傷如何誘發分裂期異常,以及分裂期異常如何誘發細胞崩猝。這些結果將有助於相關疾病的預防或治療。目前的研究主題有:(1)了解有絲分裂期細胞崩猝的分子機制;(2)探討磷脂醯肌醇(phosphatidylinositol)在有絲分裂進行時對微管動態(microtubule dynamic)和細胞抗藥性的影響(Figure 1)(3)篩檢促進有絲分裂期細胞崩猝的新穎化合物(Figure 2)

     

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    易玲輝副研究員
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    著作目錄

    1. Yi-Chen Wu and Ling-Huei Yih*. 2008. Requirement of a functional spindle checkpoint for arsenite-induced apoptosis. Journal of Cellular Biochemistry 105:678–687.
    2. Yi-Chen Wu, Wen-Yen Yen, Te-Chang Lee, and Ling-Huei Yih*. 2009. Heat shock protein inhibitors, 17-DMAG and KNK437, enhance arsenic trioxide-induced mitotic apoptosis. Toxicology and Applied Pharmacology 236: 231–238. 
    3. Yi-Chen Wu, Wen-Yen Yen, Hsiao-Yung Ho, Tsann-Long Su, and Ling-Huei Yih*. 2010. Glyfoline induces mitotic catastrophe and apoptosis in cancer cells. International Journal of Cancer. 126(4):1017-28. 
    4. R Kakadiya, Yi-Chen Wu, H Dong, Hsiao-Hui Kuo, Ling-Huei Yih*, TC Chou, Tsann-Long Su*. Novel 2-substituted quinolin-4-yl-benzenesulfonate derivatives: synthesis, antipoliferative activity, and inhibition of cellular tubulin polymerization. ChemMedChem. 6(6):1119-29. 2011 (co-corresponding)
    5. Ling-Huei Yih*, Yi-Chen Wu, Nai-Chi Hsu, and Hsiao-Hui Kuo. Arsenic Trioxide Induces Abnormal Mitotic Spindles through a PIP4KIIγ/Rho Pathway. Toxicological Sciences. 128(1):115-25. 2012. 
    6. Ling-Huei Yih*, Nai-Chi Hsu, Hsiao-Hui Kuo, and Yi-Chen Wu. Inhibition of the Heat Shock Response by PI103 Enhances the Cytotoxicity of Arsenic Trioxide. Toxicological Sciences. 128(1):126-36. 2012. 
    7. Bo-Jeng Wang, Yung-Feng Liao, Ying-Tsen Tung, Ling-Huei Yih, Cho-Chun Hu and Hsinyu Lee. Establishment of a bioluminescence-based bioassay for the detection of dioxin-like compounds. Toxicol Mech Methods. 2013 Jan 15 [Epub ahead of print]. 
    8. Ling-Huei Yih*, Nai-Chi Hsu, Yi-Chen Wu, Wen-Yen Yen, and Hsiao-Hui Kuo. Inhibition of AKT enhances mitotic cell apoptosis induced by arsenic trioxide. Toxicol Appl Pharmacol. 267(3):228-237. 2013.   

     

     

    Link to the complete list of publications


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    115台北市南港區研究院路二段128號
    Tel: 02-27899515
    Fax: 02-27858059
    icob@gate.sinica.edu.tw
    Copyright © ICOB 2013. All rights reserved. 最佳瀏覽網頁方式請用最新版IE11或其他瀏覽器 /瀏覽人數:969122--
     瀏覽人數:969122