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姓名:游智凱

職稱:副研究員兼代理副所長

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專長:Developmental Biology,
Evolution of Development

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研究人員 / 簡介
  2016- Associate Research Fellow, Institute of Cellular and Organismic Biology, Academia Sinica
  2007-2016, Assistant Research Fellow, Institute of Cellular and Organismic Biology, Academia Sinica
  2005-2007, Postdoctoral Scholar, Division of Biology, California Institute of Technology, USA.
  2005, Postdoctoral research fellow, Marine Biology Research Division, Scripps Institution of Oceanography, University of California, San Diego, USA.
  2005, Ph.D., Marine Biology Research Division, Scripps Institution of Oceanography, University of California, San Diego, USA

游智凱老師 實驗室

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    Cephalochordates (Amphioxus) are marine invertebrates. Their body plan is vertebrate-like but simpler.

    我的研究興趣在於瞭解頭索動物文昌魚的胚胎發育機制。文昌魚屬於脊索動物中的一個亞門,雖然它是無脊椎動物,但一般利用它作為一種模式生物來探討脊椎動物祖先可能具有的特徵。文昌魚與脊椎動物都具備脊索動物的基本特徵,例如:背神經管、脊索、肌節、以及鰓裂。然而脊椎動物進一步演化出文昌魚所沒有的特徵,包括:特化的頭部結構與前腦、具有遷移性的神經脊細胞群、以及經由外胚層增厚所產生的周圍感覺神經組織。我希望經由對文昌魚胚胎發育機制的研究來了解脊索動物發育的共同基礎機制;同時由於文昌魚在類緣關係上的特殊地位,文昌魚與脊椎動物的比較研究將可以提供重要的資訊來讓我們瞭解脊椎動物體制特徵發育的起源。

    本實驗室初步研究重點之一為探討神經脊 (Neural crest) 的起源。在脊椎動物胚胎發育過程中,神經脊細胞是從神經板的邊緣產生。這些細胞會由表皮性的外胚層細胞轉變成一群具遷移性的細胞,並且在到達它們的遷移終點後分化成許多種不同的細胞,包括:頭部顏面骨骼、大部分的周圍神經細系統、以及皮膚的色素細胞等等。許多脊椎動物頭部特有的複雜感覺器官都包含了神經脊細胞所分化出來的構造,因此神經脊被認為是早期脊椎動物演化的重要特點之一。我們將比較文昌魚與脊椎動物胚胎神經板發育過程中的基因表現與調控,進而去瞭解發育基因網路的改變與神經脊起源的關係。


     cDNA database for the cephalochordate amphioxus Branchiostoma floridae

     

     

     

     

     

     

  • 姓名職稱電話Email備註
    游智凱助研究員
  • PUBLICATIONS (RECENT FIVE YEARS)

    Journal articles (corresponding author #):

    1. Zieger, E., Garbarino, G., Robert, N.S.M., Yu, J.K., Croce, J.C., Candiani, S. and Schubert, M.# (2018). Retinoic acid signaling and neurogenic niche regulation in the developing peripheral nervous system of the cephalochordate amphioxus. Cell Mol Life Sci, 75, 2407-2429

    2. Yong, L.W., Bertrand, S., Yu, J.K., Escriva, H. and Holland, N.D.# (2017). Conservation of BMP2/4 expression patterns within the clade Branchiostoma (amphioxus): Resolving interspecific discrepancies. Gene Expr Patterns 25-26, 71-75.

    3. Su, Y.H.# and Yu, J.K.# (2017). EvoDevo: Changes in developmental controls underlying the evolution of animal body plans. Dev Biol 427, 177-178. (Editorial for the special issue).

    4. Kozmikova, I.# and Yu, J.K.# (2017). Dorsal-ventral patterning in amphioxus: current understanding, unresolved issues, and future directions. Int J Dev Biol 61, 601-610.

    5. Hu, H., Uesaka, M., Guo, S., Shimai, K., Lu, T.M., Li, F., Fujimoto, S., Ishikawa, M., Liu, S., Sasagawa, Y., Zhang, G., Kuratani, S., Yu, J.K., Kusakabe, T.G., Khaitovich, P., Irie, N.# and the EXPANDE Consortium (2017). Constrained vertebrate evolution by pleiotropic genes. Nat Ecol Evol 1, 1722-1730.

    6. Yue, J.X., Kozmikova, I., Ono, H., Nossa, C.W., Kozmik, Z., Putnam, N.H., Yu, J.K. and Holland, L.Z.# (2016). Conserved noncoding elements in the most distant genera of Cephalochordates: the goldilocks principle. Genome Biol Evol 8, 2387-405.

    7. Yong, L.W. and Yu, J.K.# (2016). Tracing the evolutionary origin of vertebrate skeletal tissues: insights from cephalochordate amphioxus. Curr Opin Genet Dev 39, 55-62. (IF: 5.825; Ranking: Q1; RCR: 0.60 [32.3])

    8. Lin, C.Y., Tung, C.H., Yu, J.K.# and Su, Y.H.# (2016). Reproductive periodicity, spawning induction, and larval metamorphosis of the hemichordate acorn worm Ptychodera flava. J Exp Zool B Mol Dev Evol 326, 47-60.

    9. Chang, Y.C., Pai, C.Y., Chen, Y.C., Ting, H.C., Martinez, P., Telford, M.J., Yu, J.K. and Su, Y.H.# (2016). Regulatory circuit rewiring and functional divergence of the duplicate admp genes in dorsoventral axial patterning. Dev Biol 410, 108-18.

    10. Yue, J.X., Li, K.L. and Yu, J.K.# (2015). Discovery of germline-related genes in Cephalochordate amphioxus: A genome wide survey using genome annotation and transcriptome data. Mar Genomics 24 Pt 2, 147-57.

    11. Stumpp, M., Hu, M.Y., Tseng, Y.C., Guh, Y.J., Chen, Y.C., Yu, J.K., Su, Y.H. and Hwang, P.P.# (2015). Evolution of extreme stomach pH in bilateria inferred from gastric alkalization mechanisms in basal deuterostomes. Sci Rep 5, 10421.

    12. Soukup, V., Yong, L.W., Lu, T.M., Huang, S.W., Kozmik, Z.# and Yu, J.K.# (2015). The Nodal signaling pathway controls left-right asymmetric development in amphioxus. EvoDevo 6, 5.

    13. Simakov, O.#, Kawashima, T., Marletaz, F., Jenkins, J., Koyanagi, R., Mitros, T., Hisata, K., Bredeson, J., Shoguchi, E., Gyoja, F., Yue, J.X., Chen, Y.C., Freeman, R.M., Jr., Sasaki, A., Hikosaka-Katayama, T., Sato, A., Fujie, M., Baughman, K.W., Levine, J., Gonzalez, P., Cameron, C., Fritzenwanker, J.H., Pani, A.M., Goto, H., Kanda, M., Arakaki, N., Yamasaki, S., Qu, J., Cree, A., Ding, Y., Dinh, H.H., Dugan, S., Holder, M., Jhangiani, S.N., Kovar, C.L., Lee, S.L., Lewis, L.R., Morton, D., Nazareth, L.V., Okwuonu, G., Santibanez, J., Chen, R., Richards, S., Muzny, D.M., Gillis, A., Peshkin, L., Wu, M., Humphreys, T., Su, Y.H., Putnam, N.H., Schmutz, J., Fujiyama, A., Yu, J.K., Tagawa, K., Worley, K.C., Gibbs, R.A., Kirschner, M.W., Lowe, C.J., Satoh, N.#, Rokhsar, D.S.# and Gerhart, J.# (2015). Hemichordate genomes and deuterostome origins. Nature 527, 459-65.

    14. Jandzik, D., Garnett, A.T., Square, T.A., Cattell, M.V., Yu, J.K. and Medeiros, D.M.# (2015). Evolution of the new vertebrate head by co-option of an ancient chordate skeletal tissue. Nature 518, 534-537.

    15. Yue, J.X., Yu, J.K., Putnam, N.H. and Holland, L.Z.# (2014). The transcriptome of an amphioxus, Asymmetron lucayanum, from the Bahamas: a window into chordate evolution. Genome Biol Evol 6, 2681-96.

    16. Tung, C.H., Cheng, Y.R., Lin, C.Y., Ho, J.S., Kuo, C.H., Yu, J.K.# and Su, Y.H.# (2014). A new copepod with transformed body plan and unique phylogenetic position parasitic in the acorn worm Ptychodera flava. Biol Bull 226, 69-80.

    17. Satoh, N.#, Tagawa, K., Lowe, C.J., Yu, J.K., Kawashima, T., Takahashi, H., Ogasawara, M., Kirschner, M., Hisata, K., Su, Y.H. and Gerhart, J. (2014). On a possible evolutionary link of the stomochord of hemichordates to pharyngeal organs of chordates. Genesis 52, 925-34.

    18. Ono, H., Kozmik, Z., Yu, J.K. and Wada, H.# (2014). A novel N-terminal motif is responsible for the evolution of neural crest-specific gene-regulatory activity in vertebrate FoxD3. Dev Biol 385, 396-404.

    19. Li, K.L., Lu, T.M. and Yu, J.K.# (2014). Genome-wide survey and expression analysis of the bHLH-PAS genes in the amphioxus Branchiostoma floridae reveal both conserved and diverged expression patterns between cephalochordates and vertebrates. EvoDevo 5, 20.

    *20. Chen, S.H., Li, K.L., Lu, I.H., Wang, Y.B., Tung, C.H., Ting, H.C., Lin, C.Y.#, Su, Y.H.# and Yu, J.K.# (2014). Sequencing and analysis of the transcriptome of the acorn worm Ptychodera flava, an indirect developing hemichordate. Mar Genomics 15, 35-43.

    21. Zhang, Q.J., Luo, Y.J., Wu, H.R., Chen, Y.T. and Yu, J.K.# (2013). Expression of germline markers in three species of amphioxus supports a preformation mechanism of germ cell development in cephalochordates. EvoDevo 4, 17.

    22. Lin, M.D.#, Lee, H.T., Wang, S.C., Li, H.R., Hsien, H.L., Cheng, K.W., Chang, Y.D., Huang, M.L., Yu, J.K.# and Chen, Y.H.# (2013). Expression of phosphatase of regenerating liver family genes during embryogenesis: an evolutionary developmental analysis among Drosophila, amphioxus, and zebrafish. BMC Dev Biol 13, 18.

    23. Ikuta, T., Chen, Y.C., Annunziata, R., Ting, H.C., Tung, C.H., Koyanagi, R., Tagawa, K., Humphreys, T., Fujiyama, A., Saiga, H., Satoh, N., Yu, J.K., Arnone, M.I. and Su, Y.H.# (2013). Identification of an intact ParaHox cluster with temporal colinearity but altered spatial colinearity in the hemichordate Ptychodera flava. BMC Evol Biol 13, 129

    24. Holland, L.Z.#, Carvalho, J.E., Escriva, H., Laudet, V., Schubert, M., Shimeld, S.M. and Yu, J.K. (2013). Evolution of bilaterian central nervous systems: a single origin? EvoDevo 4, 27.

     


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    115台北市南港區研究院路二段128號
    Tel: 02-27899515
    Fax: 02-27858059
    icob@gate.sinica.edu.tw
    Copyright © ICOB 2013. All rights reserved. 最佳瀏覽網頁方式請用最新版IE11或其他瀏覽器 /瀏覽人數:1144059--
     瀏覽人數:1144059