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姓名:太田欽也

職稱:副研究員

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專長:Zoology,
Evolutionary Developmental Biology,
Marine Biology

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研究人員 / 簡介

 

2011

Assistant Research Fellow, Institute of Cellular and Organismic Biology, Academia Sinica

 

2004-2011,

RIKEN CDB Research Scientist

 

2002-2004,

Research Fellow, Japan Society for the Promotion of Science (JSPS)

 

2002,

PhD. Department of Genetics, School of Life Science, The Graduate University for Advance Studies (SOKENDAI)

 

 

 

太田欽也 老師實驗室

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    Fig 1: The inshore hagfish (Eptatretus burgeri)

    Fig 2: The fertilized eggs of the hagfish

    Fig 3: The expression patterns of Sox9 gene in the hagfish embryo

    My research field is Evolutionary Developmental (EvoDevo) Biology. I seek to understand how highly sophisticated morphology and its developmental mechanisms have evolved and diverged from the common ancestor of the vertebrates. For this purpose, various evolutionary important organisms (from fish to amphibian species) are used for anatomical, histological, developmental, and molecular investigations in my lab. Current specific topics are as follows:
    1.  Hagfish EvoDevo Biology
    Hagfish has been recognized as one of the most important animal for the understanding of the common ancestral features of vertebrates because of its apparently primitive morphology and phylogenetic position (Fig. 1). However, due to the difficulty of the obtaining the embryos, there has not been progress in the developmental biology of the animal for a century. To provide further progress, we started Hagfish EvoDevo Project in Japan (RIKEN CDB) since 2005, and we succeeded in developing the experimental systems for obtaining hagfish embryos under the artificial condition (Fig.2) and analysis of the gene expression patterns in 2007.  By applying these experimental systems, we investigated neural crest cell which is one of the embryonic synapomorphy of the vertebrates. This investigation showed that the hagfish also has de-epithelialized neural crest cells as known in the jawed vertebrates (Fig. 3), indicating that the origin of the neural crest cells could date back to 500 million years ago. We are now studying on the origin of the vertebral elements, and some other morphological features which are known as important vertebrate characteristics. We are certain that our hagfish EvoDevo project will provide further understanding of the common ancestral state of the vertebrates. 
    2. Evolution of the Axial Musculoskeletal Systems 
    The highly organized axial musculoskeletal systems are known to be one of the representative features in vertebrates and have been intrigued by a few researchers in the field of developmental biology. In fact, the developmental process of the axial musculoskeletal systems have been studied by applying molecular techniques to the model organisms, including zebrafish, frog, chick, and mouse, and these studies revealed that most of axial muscle and skeletal tissues are developmentally derived from the derivatives of embryonic somite. However, our knowledge is still insufficient to depict how the developmental mechanisms of the axial musculoskeletal systems, which have provided adaptive shapes and functions for various environments, have evolved.  To tackle this, I am now developing embryological and molecular experimental systems for detailed observations of connectivity among cartilages, bones, tendons, muscles, and nerves in various non-model vertebrates, including hagfishes, lampreys, sharks, polypterus, gar, teleost fishes, lungfish, and axolotl. I expect that these non-model organisms will provide further insight into the developmental mechanisms at the common ancestors between sarcopterygian / actinopterygian, Chondrichthyes / Osteichthyes, and gnathostomes / cyclostomes, allowing us to draw the detailed evolutionary process of axial musculoskeletal systems.

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    太田欽也助研究員
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    著作目錄
    1. Ota, K. G., Oisi, Y., Fujimoto, S. & Kuratani, S. The origin of developmental mechanisms underlying vertebral elements: implications from hagfish evo-devo. Zoology (Jena) 117, 77-80, doi:10.1016/j.zool.2013.10.010 (2014).
    2. Abe, G. et al. The origin of the bifurcated axial skeletal system in the twin-tail goldfish. Nat Commun 5, 3360, doi:10.1038/ncomms4360 (2014).
    3. Tsai, H. Y., Chang, M., Liu, S. C., Abe, G. & Ota, K. G. Embryonic development of goldfish (Carassius auratus): a model for the study of evolutionary change in developmental mechanisms by artificial selection. Dev Dyn 242, 1262-1283, doi:10.1002/dvdy.24022 (2013).
    4. Ota, K. G., Fujimoto, S., Oisi, Y. & Kuratani, S. Late Development of Hagfish Vertebral Elements. J Exp Zool B Mol Dev Evol, 0, doi:10.1002/jez.b.22489 (2013).
    5. Oisi, Y., Ota, K. G., Kuraku, S., Fujimoto, S. & Kuratani, S. Craniofacial development of hagfishes and the evolution of vertebrates. Nature 493, 175-180, doi:10.1038/nature11794 (2013).
    6. 6        Oisi, Y., Ota, K. G., Fujimoto, S. & Kuratani, S. Development of the chondrocranium in hagfishes, with special reference to the early evolution of vertebrates. Zoolog Sci 30, 944-961, doi:10.2108/zsj.30.944 (2013).
    7. Fujimoto, S., Oisi, Y., Kuraku, S., Ota, K. G. & Kuratani, S. Non-parsimonious evolution of hagfish Dlx genes. BMC Evol Biol 13, 15, doi:10.1186/1471-2148-13-15 (2013).
    8. Takechi, M. et al. Overview of the transcriptome profiles identified in hagfish, shark, and bichir: current issues arising from some nonmodel vertebrate taxa. J Exp Zool B Mol Dev Evol 316, 526-546, doi:10.1002/jez.b.21427 (2011).
    9. Ota, K. G., Fujimoto, S., Oisi, Y. & Kuratani, S. Identification of vertebra-like elements and their possible differentiation from sclerotomes in the hagfish. Nat Commun 2, 373, doi:10.1038/ncomms1355 (2011).

     

     


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    115台北市南港區研究院路二段128號
    Tel: 02-27899515
    Fax: 02-27858059
    icob@gate.sinica.edu.tw
    Copyright © ICOB 2013. All rights reserved. 最佳瀏覽網頁方式請用最新版IE11或其他瀏覽器 /瀏覽人數:941103--
     瀏覽人數:941103