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姓名:李奇鴻

職稱:特聘研究員兼所長

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專長:neuroscience

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研究人員 / 簡介

  2018- Director, Institute of Cellular and Organismic Biology, Academia Sinica
  2018- Distinguished Research Fellow, Institute of Cellular and Organismic Biology, Academia Sinica
  2009- 2018 Senior Investigator, NICHD/NIH
  2006- 2018 Adjunct Professor, BISI/University of Maryland
  2002- 2009 Investigator, NICHD/NIH
  1997- 2002 Postdoctoral Fellow, UCLA/HHMI
  1997 Ph.D. degree,   Biophysics, Rockefeller Universi
     

李奇鴻老師實驗室

  • Using the Drosophila visual system as a model, we study how neurons form complex yet stereotyped synaptic connections during development and how the assembled neural circuits extract visual attributes, such as color and motion, to guide animal behaviors. To study visual circuit functions, we combine structural and functional approaches to map visual circuits. With targeted manipulation of neuronal activity, we identified specific neurons that are functionally required for color-driven behaviors. Using both light- and electron-microscopy (EM) studies, we mapped the neurons' synaptic circuits. For circuit development, we focus on the formation of synaptic connections between the chromatic photoreceptors and their synaptic partners in the medulla neuropil. We used high-resolution imaging techniques and genetic manipulations to delineate the molecular mechanisms that control dendritic patterning and synaptic specificity of the medulla neurons.

  • 姓名職稱電話Email備註
    李奇鴻特聘研究員兼所長
    林子暘研究助技師
    李岩博士後研究員
    潘宜欣研究助理
    甘淑儀工讀生
  • Song, B.-M., and Lee, C.-H. (2018) Toward a Mechanistic Understanding of Color Vision in Insects. Front. Neural Circuits 12:16. (PDF). 

    Biswas, T M., and Lee, C.-H. (2017) Visual Motion: Cellular Implementation of a Hybrid Motion Detector. Curr Biol. 27:R274-R276. (PDF).

    Ting, C.-Y., McQueen, P. G., Pandya, N., McCreedy, E. S., McAuliffe, M., Lee, C.-H. (2017) Analyzing Dendritic Morphology in Columns and Layers. JoVE 121; 55410. (PDFVideo)

    Li, Y.#, Dharkar, P.#, Han, T.-H., Serpe, M., Lee, C.-H.#, Mayer, M.L.# (2016) Novel Functional Properties of Drosophila CNS Glutamate Receptors. Neuron 92: 1036–1048. (PDFVideo abstract)

    Luo, J., McQueen, P. G., Shi, B., Lee, C.-H., and Ting, C.-Y. (2016) Wiring dendrites in layers and columns. J. Neurogenetics. 30: 69-79. (PubMed).

    Kulkarni, A., Ertekin, D., Lee, C.-H., and Hummel, T. (2016) Birth order dependent growth cone segregation determines synaptic layer identity in the Drosophila visual system. eLife 5:e13715. (PDF)

    Lin, T.-Y., Luo, J., Shinomiya, K., Ting, C.-Y., Lu, Z., Meinerzhagen. I.A., and Lee, C.-H. (2016) Mapping Chromatic Pathways in the Drosophila Visual System. J Comp Neurol. 524:213-227. (PDF) (Cover)

    Macpherson, L.J., Zaharieva, E.E., Kearney, PJ., Alpert, M.H., Lin, T.-Y., Turan, Z., Lee, C.-H., Gallio, M. (2015) Dynamic labelling of neural connections in multiple colours by trans-synaptic fluorescence complementation. Nat Commun. 10024. (PDF)

    Miyazaki, T., Lin, T.-Y., Ito, K, Lee, C.-H., and Stopfer, M. (2015) A gustatory second-order neuron that connects sucrose-sensitive primary neurons and a distinct region of the gnathal ganglion in the Drosophila brain. J. Neurogenetics. 29: 144-155. (PDF)

    Melnattur, K.V., Pursley, R., Lin, T.-Y., Ting, C.-Y., Smith, P.D., Pohida, T. and Lee, C.-H. (2014) Multiple Redundant Medulla Projection Neurons Mediate Color Vision in Drosophila. J. Neurogenetics. 28:374-388. (PDF)

    Shinomiya, K., Karuppudurai, T., Lin, T.-Y., Lu, Z., Lee, C.-H., Meinertzhagen, I.A. (2014) Candidate Neural Substrates for Off-Edge Motion Detection in DrosophilaCurr Biol. 10:1062-70. (PDF) (Dispatch)

    Ting, C.-Y.#, McQueen, P. G.#, Pandya, N., Lin, T.-Y., Yang, M., Reddy, O. V., O’Connor, M. B., McAuliffe, M. and Lee, C.-H. (2014) Photoreceptor-Derived Activin Promotes Dendritic Termination and Restricts the Receptive Fields of First-Order Interneurons in DrosophilaNeuron 81: 830-46. (PDF).

    Karuppudurai, T.#, Lin, T.-Y.#, Ting, C.-Y., Pursley. R., Melnattur, K. V., Diao, F., White, B. H., Macpherson, L. J., Gallio,M., Pohida, T. and Lee, C.-H. (2014) A Hard-wired Glutamatergic Circuit Pools and Relays UV Signals to Mediate Spectral Preference in DrosophilaNeuron 81: 603-615. (PDFVideo abstract) (Recommended in F1000Prime).

    Kundu, M., Kuzin, A., Lin, T.-Y., Lee, C.-H., Brody, T., Odenwald, WF. (2013) cis-Regulatory Complexity within a Large Non-Coding Region in the Drosophila Genome. PLOS one 8: e60137 (PDF)

    Meinertzhagen, I.A and Lee, C.-H. (2012) The Genetic Analysis of Functional Connectomics in DrosophilaAdv Genet 80: 99-151. (PDF)

    Wardill, T.J., List, O., Li, X., Dongre, S., McCulloch, M., Ting, C.-Y., O’Kane, C. J., Tang, S., Lee, C.-H., Hardie, R. C., Juusola, M. (2012) Multiple Spectral Inputs Contribute to Motion Discrimination in the Drosophila Visual System. Science 336: 925-931.(PDF).

    Brody, T., Yavatkar, A.S., Kuzin, A., Kundu, M., Tyson, L.J., Ross. J., Lin, T.-Y., Lee, C.-H., Awasaki, T., Lee, T., Odenwald. W.F. (2012) Use of a Drosophila genome-wide conserved sequence database to identify functionally related cis-regulatory enhancers. Dev Dyn 241: 169-189. (PDF)

    Takemura, S.#, Karuppudurai,  T.#, Ting, C.-Y., Lu,  Z., Lee, C.-H.#, Meinertzhagen, I.A.# (2011) Cholinergic circuits integrate neighboring visual signals in a Drosophila motion detection pathway. Curr Biol. 21: 2077-2084. (PDF) (Dispatch).

    Melnattur, K.V. and Lee, C.-H. (2011) Visual Circuit Assembly in DrosophilaDev Neurobiol 36: 1286-96 (PDF)

    Ting, C.-Y., Gu, S., Guttikonda, S., Lin, T.-Y., White, B.H., Lee, C.-H. (2011) Focusing transgene expression in Drosophila by coupling Gal4 with a novel split-LexA expression system. Genetics 188: 229-233 (PDF)

    Lee, C.-H. (2010) The split view of motion. Nature 486: 178-179.(PDF)

    Hsu, S.N., Yonekura, S, Ting, C.-Y., Robertson, H.M., Iwai, Y., Uemura, T., Lee, C.-H., Chiba, A. (2009) Conserved alternative splicing and expression patterns of arthropod N-cadherin. PLoS Genet 5: e1000441.(PDF)

    Meinertzhagen, I.A., Takemura, S.-y., Lu, Z., Huang, S., Gao, S., Ting, C.-Y., Lee, C.-H. (2009) From form to function: the ways to know a neuron. J. Neurogenetics 29: 828-41.(PDF)

    Gao, S.#, Takemura, S.-y.#, Ting, C.-Y.#, Huang, S., Lu, Z., Luan, H., Rister, J., Thum, A. S., Yang, M., Hong, S.-T., Wang, J.W., Odenwald, W.F., White, B.H., Meinertzhagen, I.A., Lee, C.-H. (2008) The Neural Substrate of Spectral Preference in DrosophilaNeuron 60, 328-42.(PDF)

    Root, C.M., Masuyama, K., Green, D.S., Enell, L.E., Nassel, D.R., Lee, C.-H., Wang, J.W. (2008) A presynaptic gain control mechanism fine-tunes olfactory behavior. Neuron 59, 311-21.(PDF)

    Ting, C.-Y.#, Herman, T.#, Yonekura S., Gao, S., Wang, J., Serpe, M., O'Connor, M.B., Zipursky, S.L., Lee, C.-H. (2007) Tiling of R7 axons in the Drosophila visual system is mediated both by transduction of an Activin signal to the nucleus and by mutual repulsion. Neuron 56: 793-806.(PDF) (Perspective)

    Rister, J., Pauls, D., Schnell, B., Ting, C.-Y., Lee, C.-H., Sinakevitch, I., Morante, J., Strausfeld, N.J., Ito, K., Heisenberg, M. (2007) Dissection of the Peripheral Motion Channel in the Visual System of Drosophila melanogaster. Neuron 56, 155-70.(PDF)

    Yonekura S., Lei Xu, Ting C.-Y., Lee C.-H. (2007) Adhesive but not signaling activity of Drosophila N-cadherin is essential for photoreceptor target selection. Dev Biol 304: 759-70.(PDF)

    Ting C.-Y., Lee C.-H. (2007)Visual circuit development. Curr Opin Neurobiol 17: 65-72.(PDF)

    Yonekura S.#, Ting C.-Y.#, Neves G., Hung K., Hsu S., Chiba A., Chess A., Lee C.-H. (2006) The variable transmembrane domain of Drosophila N-cadherin regulates adhesive activity. Mol Cell Biol 20: 6598-6608.(PDF , supp)

    Pramatarova A, Ochalski PG, Lee C.-H., Howell B.W. (2006) Mouse disabled 1 regulates the nuclear position of neurons in a Drosophila eye model. Mol Cell Biol 26: 1510-7.(PDF)

    Ting C.-Y.#, Yonekura S.#, Chung, P., Hsu, S., Robertson, H.M., Chiba, A., Lee, C.-H., (2005) Drosophila N-cadherin functions in the first stage of the two-stage layer-selection process of R7 photoreceptor afferents. Development 132: 953-963.(PDF,supp)

    Lee, R. C., Clandinin, T.  R., Lee, C.-H., Chen, P.L., Meinertzhagen, I. A., Zipursky, S. L., (2003) The protocadherin Flamingo is required for axon target selection in the Drosophila visual system. Nat Neurosci 6: 557-63.(PDF,supp)

    Clandinin, T. R.#, Lee, C.-H.#, Herman, T., Lee, R. C., Yang, A. Y., Ovasapyan, S., and Zipursky, S. L., (2001) Drosophila LAR regulates R1-R6 and R7 target specificity in the visual system. Neuron 32: 237-248.(PDF)

    Lee, C.-H.#, Herman, T.#, Clandinin, T.R., Lee, R., Zipursky, S.L., (2001) N-cadherin regulates target specificity in the Drosophila visual system. Neuron 30: 437-50.(PDF)

    Garrity, P.A.#, Lee, C.-H.#, Salecker, I.#, Robertson, H.C., Desai, C.J., Zinn, K. and Zipursky, S.L. (1999) Retinal axon target selection in Drosophila is regulated by a receptor protein tyrosine phosphatase. Neuron 22: 707-717.(PDF)

    Lee, C.-H., Cowburn, D., Kuriyan, J. (1998) Peptide recognition mechanisms of eukaryotic signaling modules. Methods Mol. Biol 84: 3-31.

    Zhang, Z., Lee, C.-H.*, Mandiyan, V., Borg, J.P., Margolis, B., Schlessinger, J., Kuriyan, J., (1997) Sequence-specific recognition of the internalization motif of the Alzheimer's amyloid precursor protein by the X11 PTB domain. EMBO J 16: 6141-6150.(PDF)

    Moarefi, I., LaFeyre-Bernt., M., Sicheri, F., Huse, M., Lee, C.-H., Kuriyan, J., Miller, W.T. (1997) Activation of the Src-family tyrosine kinase Hck by SH3 domain displacement. Nature 385: 650-653.(PDF)

    Lee, C.-H., Saksela, K., Mirza, U., Chait, B. and Kuriyan, J. (1996) Crystal structure of the conserved core of HIV-1 Nef complexed with a Src-family SH3 domain. Cell 85: 931-942.(PDF)

    Lee, C.-H., Leung, B., Lemmon, M.A., Zheng, J., Cowburn, D., Kuriyan, J. and Saksela, K. (1995) A single amino acid in the SH3 domain of Hck determines its high affinity and specificity in binding to HIV-1 Nef protein. EMBO J 14: 5006-5015.(PDF)

    Lee, C.-H., Kominos, D., Jacques, S., Margolis, B., Schlessinger, J., Shoelson, S.E. and Kuriyan, J. (1994) Crystal structures of peptide complexes of the amino-terminal SH2 domain of the Syp tyrosine phosphatase. Structure 15: 423-438.(PDF)

    Lee, C.-H., Lee, E.-C., Tai, S.-T., Kung, H.-J., Liu, Y.-C. and Hwang, J. (1993) A recombinant protein composed of Epidermal growth factor and Pseudomonas Exotoxin A with a deletion of toxin binding domain specifically kills EGF-receptor bearing cells. Protein Engineering 6: 433-440.(PDF)

    Skolnik, E.Y., Batzer, A.G., Li, N., Lee, C.-H., Lowenstein, E., Mohammedi, M., Margolis, B. and Schlessinger, J. (1993) The function of GRB2 in linking the insulin receptor to Ras signaling pathways. Science 260: 1953-1955.(PDF)

    Skolnik, E.Y., Lee, C.-H., Batzer, A.G., Zhou, M., Daly, R., Backer, J., White, M.F., Jr., and Schlessinger, J. (1993) The SH2/SH3 domain containing protein GRB2 implicated in RAS signaling interacts with two insulin induced substrates. EMBO J 12: 1929-1936.(PDF)

    Lee, C.-H., Li, W., Nishimura, R., Zhou, M., Batzer, A.G., Myers, M.G., White, M.F., Jr., Schlessinger, J. and Skolnik, E.Y. (1993) Nck associates with the SH2 domain-docking protein IRS-1 in insulin-stimulated cells. Proc Natl Acad Sci USA 90: 11713-11717.(PDF)

  • 實驗室新血招募中(博士後研究、博班生、研究助理)。歡迎對神經科學研究有高度熱忱之年輕朋友加入。

    意者請email 李所長信箱 (leechih@gate.sinica.edu.tw)

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    115台北市南港區研究院路二段128號
    Tel: 02-27899515
    Fax: 02-27858059
    icob@gate.sinica.edu.tw
    Copyright © ICOB 2013. All rights reserved. 最佳瀏覽網頁方式請用最新版IE11或其他瀏覽器 /瀏覽人數:1133654--
     瀏覽人數:1133654