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姓名:丘淑鈴

職稱:助研究員

電話: 02-2789-9536

專長:Synaptic Plasticity, Neural Development, Learning and Memory

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研究人員 / 簡介

2019 Assistant Research Fellow, Institute of Cellular and Organismic Biology, Academia Sinica, Taiwan
2016-2019 Research Associate, The Johns Hopkins University School of Medicine, Maryland, USA
2008-2016 Postdoctoral Fellow, The Johns Hopkins University School of Medicine, Maryland, USA
2002-2008 Ph.D. program, Watson School of Biological Sciences, Cold Spring Harbor Laboratory, USA

丘淑鈴老師實驗室

  • 我們實驗室致力於學習和記憶的分子/細胞機制研究。應用多元的專業技術 (包括電生理學,生物化學,細胞生物學,生物活體成像和動物行為學等),以及不同的實驗模式系統 (包括原生神經細胞和小鼠),我們希望能深入了解神經細胞是如何發育和整合到不同的迴路中以執行大腦的認知功能。我們特別感興趣的研究方向如下:

    1) 神經細胞如何在發育過程中建立正確的連結和大腦迴路;

    2) 神經突觸可塑性 (synaptic plasticity) 如何影響動物的學習和記憶;

    3) 神經突觸失能(synaptic dysfunction) 如何導致智力障礙(Intellectually Disability)和自閉症症候群(Autism Spectrum Disorder) 等常見的人類大腦神經發育障礙。

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    Selected publications

    1. Mejias R, Chiu S-L, Han M, Rose R, Gil-Infante A, Zhao Y, Huganir RL, Wang T. 2019 Purkinje cell-specific Grip1/2 knockout mice show increased repetitive self-grooming and enhanced mGluR5 signaling in cerebellum. Neurobiol Dis. 132:104602
    2. Wang Q, Chiu S-L*, Koropouli E*, Hong I*, Mitchell S, Easwaran TP, Hamilton N, Gustina A, Zhu Q, Ginty DD, Huganir RL, Kolodkin AL. 2017 Neuropilin-2/PlexinA3 receptors associate with GluA1 and mediate Sema3F-dependent homeostatic scaling in cortical neurons. Neuron 96(5): 1084-1098 (*: Equal contribution)
    3. Chiu S-L, Diering G, Ye B, Takamiya K, Jiang Y, Niranjan T, Schwartz CE, Wang T and Huganir RL. 2017 GRASP1 regulates synaptic plasticity and memory through endosomal recycling of AMPA receptors. Neuron 93(6): 1405-1419
    4. Han M, Mejias R, Chiu S-L, Rose R, Adamczyk, A, Huganir RL and Wang T. 2017 Mice lacking GRIP1/2 show increased social interactions and enhanced phosphorylations at GluA2-S880. Behavioural Brain Research 321: 176-84
    5. Chen C-M, Orefice L*, Chiu S-L*, LeGates T, Hattar S, Huganir RL, Zhao H, Xu B and Kuruvilla R. 2017 Wnt5a is essential for hippocampal dendritic maintenance and spatial learning and memory in adult mice. Proc Natl Acad Sci USA 114(4): E619-28 (*: Equal contribution)
    6. Gu Y, Chiu S-L, Liu B, Wu PH, Delannoy M, Lin DT, Wirtz D and Huganir RL. 2016 Differential vesicular sorting of AMPA and GABAA receptors. Proc Natl Acad Sci USA 113 (7): E922-31
    7. Zhang K, Donnelly CJ, Haeusler AR, Grima JC, Machamer JB, Steinwald P, Daley EL, Miller SJ, Cunningham KM, Vidensky S, Gupta S, Thomas MA, Hong I, Chiu S-L, Huganir RL, Ostrow LW, Matunis MJ, Wang J, Sattler R, Lloyd TE, Rothstein JD. 2015 The C9orf72 repeat expansion disrupts nucleocytoplasmic transport. Nature 525(7567): 56-61
    8. Volk L, Chiu S-L, Sharma K, Huganir RL. 2015 Glutamate synapses in human cognitive disorders. Annual Review of Neuroscience 38(1): 127-49
    9. Thomas GM, Hayashi T, Chiu S-L, Chen CM and Huganir RL. 2012 Palmitoylation by DHHC5/8 targets GRIP to dendritic endosomes to regulate AMPA-R trafficking. Neuron 73(3): 482-96
    10. Li J, Wang Y, Chiu S-L, Cline HT. 2010. Membrane targeted horseradish peroxidase as a marker for correlative fluorescence and electron microscopy studies. Front Neural Circuits. 26(4): 6
    11. Chiu S-L and Cline HT. 2010. Insulin receptor signaling in the development of neuronal structure and function. Neural Development 5(7)
    12. Chen C-M*, Chiu S-L*, Cline HT. 2009. Co-expression of Argonaute2 enhances short hairpin RNA-induced RNA interference in Xenopus CNS neurons in vivo. Front. Neurosci. 9(3):63. ( *: Equal contribution)
    13. Chiu S-L, Chen CM, Cline HT. 2008. Insulin receptor signaling regulates synapse number, dendritic plasticity and circuit function in vivo. Neuron 58(5): 708-719
    14. Bestman JE*, Ewald RC*, Chiu S-L*, Cline HT. 2006. In vivo single-cell electroporation for transfer of DNA and macromolecules. Nature Protocols. 1(3): 1267-1272 ( *: Equal contribution)
    15. Chiang A-S, Lin W-Y, Liu H-P, Pszczolkowski MA, Fu T-F, Chiu S-L, Holbrook GL. 2002. Insect NMDA receptors mediate juvenile hormone biosynthesis. Proc Natl Acad Sci USA. 99(1): 37-44
    16. Chiang A-S, Liu Y-C, Chiu S-L, Hu S-H, Huang C-Y, Hsieh C-H. 2001. Three-dimensional mapping of brain neuropils in the cockroach, Diploptera punctata. J. Comp. Neurol. 440: 1-11
  • 我們的學習和記憶實驗室於今年9月正式開張,歡迎生物相關科系畢業,對神經科學研究有興趣的人員加入我們的研究團隊。

    意者請將履歷以[應徵碩士或學士級研究助理] 或為標題 ,email 至丘老師信箱 slchiu@gate.sinica.edu.tw.
    履歷請簡述學 / 經歷、應徵動機、對此份工作的期望及未來的規劃,以及 1- 2 位推薦人的連絡資訊。應徵碩士級研究助理或博士後研究者請加附研究論文的中/英文摘要


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    icob@gate.sinica.edu.tw  Copyright © ICOB 2013. All rights reserved. 最佳瀏覽網頁方式請用最新版IE11或其他瀏覽器 -- 瀏覽人數:1515281
    115台北市南港區研究院路二段128號
    Tel: 02-27899515
    Fax: 02-27858059
    icob@gate.sinica.edu.tw
    Copyright © ICOB 2013. All rights reserved. 最佳瀏覽網頁方式請用最新版IE11或其他瀏覽器 /瀏覽人數:1515281--
     瀏覽人數:1515281