Post-doctoral position available at Research Group on Marine Eco-Evo-Devo (Dr. Vincent Laudet's lab)
Institute of Cellular and Organismic Biology (ICOB) – Academia Sinica
Post-doctoral position at Research Group on Marine Eco-Evo-Devo (Vincent Laudet)
at Yilan Marine Research Station
The Institute of Cellular and Organismic Biology (ICOB; http://icob.sinica.edu.tw) is one of the research institutes of Academia Sinica in Taiwan. Researchers at ICOB investigate the basic mechanisms underlying cellular functions and cell-cell interactions that coordinate the growth and development of an organism and its adaptation to an ever-changing environment. Current research at ICOB comprises four focus areas: (1) Cellular dysfunction, (2) Eco-Evo-Devo, (3) Neuroscience, and (4) Stem cell and regenerative biology.
Prof. Vincent Laudet Marine Eco-Evo-Devo group uses coral reef fishes, and in particular anemonefish, to better understand the role of hormones in life history transition, and specifically metamorphosis. Prof. Vincent Laudet’s lab is jointly supported by Academia Sinica and Okinawa Institute of Science and Technology (OIST) in Japan (https://groups.oist.jp/meedu).
We seek for a highly motivated post-doctoral fellow to join the Marine Eco-Evo-Devo laboratory of Prof. Vincent Laudet at Yilan Marine Research Station in Taiwan. The post-doc will participate to a collaborative project between 4 research teams at ICOB that aim to study metamorphosis of 5 marine organisms that occupy key phylogenetic positions and exhibit different life history strategies: a teleost fish, a cephalochordate, a hemichordate, an echinoderm, and an annelid worm. Transcriptomic profiling of key organs and hormone analysis of several developmental stages of all 5 species will be investigated and compared to each other. The post-doc will be responsible for the fish part, using clownfish as a model system. She/He will determine if similar transformations of organs occur in terms of cellular processes, with a focus on the intestine (key organ facing changes during metamorphosis). By examining transcriptomic regulation during metamorphosis at both organismic and single-cell level, she/he will search for shared regulatory mechanisms among these distantly related animal models. Lastly, she/he will perform functional analysis (such as pharmacological treatment, CRISPR/cas9…) to test whether these shared regulatory mechanisms are essential for metamorphosis. This position will imply interactions with dynamic international research groups that aim to published in high impact journals.
Marine Research Station – ICOB - 23-10, Dah-Uen Rd, Jiau Shi, YLan 262 Taiwan
1. PhD in Developmental Biology, Cellular Biology or Evolutionary Biology (or related topics).
2. Knowledge of basic techniques in developmental biology techniques and molecular biology.
3. Previous experience working with experimental model organisms.
4. Proficiency in oral and written English.
5. Ability to collaborate, share results and communicate with scientists from other fields.
1. Experience working with fish model organisms.
2. Experience working with transcriptomic data.
3. Good knowledge in endocrinology.
Salary start from NT58,858.
How to Apply:
Apply by emailing your Submission Documents to: vincent.laudet [at] oist.jp
(Please replace [at] with @ before using this email address)
- Cover letter summarising research interests, professional experience, and career goals.
- Curriculum vitae.
- Name and contact information of 3 referees, one of which should be a previous employer.
Recent Publications of the lab in this area
Holzer G, Besson M, Lambert A, François L, Barth P, Gillet B, Hughes S, Piganeau G, Leulier F, Viriot L, Lecchini D Laudet V. Larval fish recruitment to reefs is a thyroid hormone-mediated metamorphosis sensitive to the pesticide chlorpyrifos. eLife, 2017 30: 6. pii: e27595.
Salis P, Roux N, Soulat O, Lecchini D, Laudet V. Frederich B. Ontogenetic and phylogenetic simplification during white stripe evolution in clownfishes. BMC Biology, 2018 16: 90.
Salis P, Lorin T, Laudet V, Frédérich B. Magic Traits in Magic Fish: Understanding Color Pattern Evolution Using Reef Fish. Trends in Genetics. 2019, 35: 265-278
Salis P, Roux N, Huang D, Marcionetti A, Mouginot P, Reynaud M, Salles O, Salamin N, Pujol B, Parichy DM, Planes S, Laudet V. Thyroid hormones control the formation and plasticity of white bars in clownfishes. Proc. Natl. Acad. Sci. USA, 2021, 118 : .
Roux N, Salis P, Lambert A, Logeux V, Soulat O, Frederich B, Lecchini D and Laudet V. Staging and normal table of post-embryonic development of the clownfish (Amphiprion ocellaris). Developmental Dynamics, 2019, 248: 545-568.
Besson M, Feeney WE, Moniz I, François L, Brooker RM, Holzer G, Metian M, Roux N, Laudet V, and Lecchini D. Anthropogenic stressors impact fish sensory development and survival via thyroid disruption. Nature Communication, 2020 11: 3614.