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研究人員｜中央研究院 細胞與個體生物學研究所

研究人員
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側邊選單開關 研究人員
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文章內容區

友善列印
經歷簡介展開收合
2015-present
Research Fellow, Marine Research Station, Institute of Cellular and Organismic Biology, Academia Sinica, Taiwan
2011-2015
Associate Research Fellow, Marine Research Station, Institute of Cellular and Organismic Biology, Academia Sinica, Taiwan
2007- 2011
Assistant Research Fellow, Marine Research Station, Institute of Cellular and Organismic Biology, Academia Sinica, Taiwan
2003- 2007
Assistant Research Scientist, Marine Research Station, Institute of Cellular and Organismic Biology, Academia Sinica, Taiwan
2001- 2002
Postdoctoral Research Associate, The Sanger Institute Wellcome Trust, Cambridge U.K.
2000- 2001
Postdoctoral Research Fellow, Institute of Zoology, Academia Sinica, Taiwan
1997
Ph.D. Institute of Zoology, National Taiwan University, Taiwan
研究方向展開收合

抗菌胜肽，就是一種可以對抗微生物的胜肽，小於100個胺基酸的一種胜肽，又名「抗菌蛋白」。抗菌胜肽幾乎可以在各種生物中被發現，而抗菌胜肽更是生物個體先天性免疫中重要的一環。抗菌胜肽都有一些共通的特性: 分子量小、帶正電(帶有+2~+9價電荷)、具有明顯的兩極性，因此抗菌胜肽才能與磷脂膜有很強的相互作用與滲透磷脂膜的能力，這也是抗菌胜肽之所以具有抗菌功能的關鍵；但是在眾多抗菌胜肽上，不論在立體結構或是胺基酸序列上，都有許多差異性。近年來研究發現，抗菌胜肽除了能對抗革蘭氏陰性菌與革蘭氏陽性菌之外，更多的研究學者發現，抗菌胜肽還具有對抗臨床致病菌株、黴菌、真菌、寄生蟲與具有外套膜的病毒，更還發現具有對抗癌症的功能，因此具有抗癌功能的此類抗菌胜肽則特別稱為抗癌胜肽，這對急於發展新興的抗癌藥物而言，是一項很重大發現。實驗室的研究方向與興趣如下：

1) 使用各種修飾方法，例如蛋白質工程學、化學工程學，修改抗菌肽並降低其毒性、溶血性，增強其在不同離子濃度與血液中之半衰期長度。

2) 探討抗菌肽在抗革蘭氏陰性菌、抗革蘭氏陽性菌、抗黴菌、抗真菌、抗寄生蟲、抗病毒，與抗癌症上的機能性與相關藥物研發。

3) 抗菌胜肽在細胞上之分子機制探討。

代表著作展開收合
  1. Bor-Chyuan Su, Chieh-Yu Pan, Jyh-Yih Chen* (2019). Antimicrobial peptide TP4 induces ROS-mediated necrosis by triggering mitochondrial dysfunction in wild-type and mutant p53 glioblastoma cells. Cancers (Basel). Cancers (Basel). 2019 Feb 1;11(2). pii: E171. doi: 10.3390/cancers11020171. *Corresponding author. 
  2. Bor-Chyuan Su, Han-Ning Huang, Tai-Wen Lin, Chwan-Deng Hsiao, Jyh-Yih Chen* (2017). Epinecidin-1 protects mice from LPS-induced endotoxemia and cecal ligation and puncture-induced polymicrobial sepsis. BBA - Molecular Basis of Disease (in press) *Corresponding author.
  3. Jayaram Lakshmaiah Narayana, Han-Ning Huang, Chang-Jer Wu*, Jyh-Yih Chen* (2015). Epinecidin-1 Bactericidal Activity: Membrane Destabilization via Saddle-Splay Curvature Generation, and Modulation of Helicobacter pylori-Induced Host Immune Responses in a Mouse Model. Biomaterials 61:41-51. *Corresponding author. 
  4. Wu-Fu Chen, Shi-Ying Huang, Chang-Yi Liao, Chun-Sung Sung, Jyh-Yih Chen*, Zhi-Hong Wen* (2015). The use of the antimicrobial peptide piscidin (PCD)-1 as a novel anti-nociceptive agent. Biomaterials 53:1-11. *Corresponding author. 
  5. Chen-Hung Ting, Han-Ning Huang, Tsui-Chin Huang, Chang-Jer Wu, Jyh-Yih Chen* (2014). The mechanisms by which pardaxin, a natural cationic antimicrobial peptide, targets the endoplasmic reticulum and induces c-FOS. Biomaterials 35(11):3627-3640. *Corresponding author. 
  6. Han-Ning Huang, Venugopal Rajanbabu, Chieh-Yu Pan, Yi-Lin Chan, Chang-Jer Wu*, Jyh-Yih Chen* (2013). Use of the antimicrobial peptide Epinecidin-1 to protect against MRSA infection in mice with skin injuries. Biomaterials 34(38):10319-10327. *Corresponding author. 
  7. Han-Ning Huang, Venugopal Rajanbabu, Chieh-Yu Pan, Yi-Lin Chan, Chang-Jer Wu*, Jyh-Yih Chen* (2013). A cancer vaccine based on the marine antimicrobial peptide pardaxin (GE33) for control of bladder-associated tumors. Biomaterials 34(38):10151-10159. *Corresponding author. 
  8. Han-Ning Huang, Venugopal Rajanbabu, Chieh-Yu Pan , Yi-Lin Chan, Cho-Fat Hui, Jyh-Yih Chen*, Chang-Jer Wu* (2011). Modulation of the immune-related gene responses to protect mice against Japanese encephalitis virus using the antimicrobial peptide, tilapia hepcidin 1-5. Biomaterials 32(28):6804-14. *Corresponding author. 
  9. Han-Ning Huang, Chieh-Yu Pan, Venugopal Rajanbabu, Chang-Jer Wu*, Jyh-Yih Chen* (2011). Modulation of immune responses by the antimicrobial peptide, epinecidin (Epi)-1, and establishment of an Epi-1 based inactivated vaccines. Biomaterials 32(14):3627-3636. *Corresponding author. 
  10. Venugopal Rajanbabu, Jyh-Yih Chen* (2011). Applications of antimicrobial peptides from fish and perspectives for the future. Peptides 32(2):415-420. *Corresponding author.