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Sam's Neuroscience Laboratory｜Institute of Cellular and Organismic Biology, Academia Sinica

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Sam's Neuroscience Laboratory

  • Hung-Hsiang Yu
    Associate Research Fellow
    • SpecialtyNeural Development, Neuroscience
    • E-mailsamhhyu@gate.sinica.edu.tw
    • Tel02-2787-1546
    • LabR334/ICOB
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Lab IntroductionOpenClose

We utilize the Drosophila olfactory system as a model to investigate how the olfactory system is assembled during development. Olfactory projection neurons (PN) connect with olfactory sensory neurons in the antennal lobe (AL) and neurons in the mushroom body (MB/the Drosophila learning and memory center) and the lateral horn to generate an accurate olfactory connectivity map to endow the olfactory system with the sensitive, robust and accurate odor-processing ability. We would like to determine cellular and molecular mechanisms underlying how Semaphorin-1a (Sema-1a), a transmembrane guidance protein, regulates the generation of proper PN dendritic patterns in the AL. We also would like to investigate mechanisms underlying the development of MB neurons in the construction of the functional olfactory system.

Lab MemberOpenClose
Name Job Title Telephone Email Remark
Hung-Hsiang Yu Associate Research Fellow 02-2787-1546 samhhyu@gate.sinica.edu.tw
Sao-Yu Chu Research Assistant 02-2787-1545 fantasy0879@gate.sinica.edu.tw
Kai-Yuan Ku Research Assistant 02-2787-1545 ej3d93m06@gmail.com
PublicationOpenClose
  1. Lai, Y.W., Miyares, R.L., Liu, L.Y., Chu, S.Y., Lee, T. and Yu, H.H. (2022). Hormone-controlled changes in the differentiation state of post-mitotic neurons. Current Biology 32, 2341-2348. doi: 10.1016/j.cub. 2022.04.027.
  2. Wei, J.Y., Chu, S.Y., Hung, Y.C., Chung, P.C. and Yu, H.H. (2022). Drosophila septin interacting protein 1 regulates neurogenesis in the early developing larval brain. Scientific Reports, 12 (1): 292. doi: 10.1038/ s41598-021-04474-3.
  3. Lin, T.Y., Chen, J.P., Yu, H.H., Hsu C.P. and Lee, C.H. (2021). Extrinsic factors regulating dendritic patterning. Front. Cell. Neuroscience, 14, 622808. doi: 10.3389/ fncel.2020.622808.
  4. Garcia-Marques, J., Espinosa-Medina, I., Ku, K.Y., Yang, C.P., Koyama, M., Yu, H.H. and Lee, T. (2020).  A programmable sequence of reporters for lineage analysis. Nature Neuroscience, 23: 1618-1628. doi: 10. 1038/s41593-020-0676-9.
  5. Lai, Y.W., Chu, S.Y., Li, J.C., Chen, P.L., Chen, C.H. and Yu, H.H. (2020).  Visualization of Endogenous Type I TGF-β Receptor Baboon in the Drosophila Brain. Scientific Reports 10 (1): 5153. doi: 10.1038/s41598-020-61950-y.
  6. Hsu, T.C., Ku, K.Y., Shen, H.C. and Yu, H.H. (2020). Overview of MARCM-related technologies in Drosophila neurobiological research. Current Protocols in Neuroscience, 91, e90. doi: 10.1002/cpns.90.
  7. Wei, J.Y., Chung, P.C., Chu, S.Y., and Yu, H.H. (2019). FOXO Regulates Cell Fate Specification of Drosophila Ventral Olfactory Projection Neurons. Journal of Neurogenetics, 33(1): 33-40.  doi: 10.1080/01677063. 2018.1556651.
  8. Shen, H.C., Chu, S.Y., Hsu, T.C., Wang, C.H., Lin, I.Y. and Yu, H.H. (2017). Semaphorin-1a Prevents Drosophila Olfactory Projection Neuron Dendrites from Mis-targeting into Select Antennal Lobe Regions. PLOS Genetics 13(4): e1006751. doi: 10.1371/journal.pgen.1006751. 
  9. Shen, H.C., Hsu, T.C., Chung, P.C., and Yu, H.H. (2017). Cell Lineage Analyses and Gene Function Studies Using Twin-Spot MARCM. Journal of Visualized Experiments 121: 555278. doi: 10.3791/55278.
  10. Lai, Y.W., Chu, S.Y., Wei, J.Y., Cheng, C.Y., Li, J.C., Chen, P.L., Chen, C.H. and Yu, H.H. (2016). Drosophila microRNA-34 Impairs Axon Pruning of Mushroom Body γ Neurons by Downregulating the Expression of Ecdysone Receptor. Scientific Reports 6: 39141. doi: 10.1038/srep39141.
  11. .Shen, H.C., Wei, J.Y., Chu, S.Y., Chung, P.C., Hsu, T.C. and Yu, H.H. (2016). Morphogenetic Studies of the Drosophila DA1 Ventral Olfactory Projection Neuron. PLOS One 11 (5): e0155384. doi: 10.1371/journal. pone.0155384.
  12. .Yang, J.S., Awasaki, T., Yu, H.H., He, Y., Ding, P., Kao, J.C. and Lee, T. (2013). Diverse Neuronal Lineages Make Stereotyped Contributions to the Drosophila Locomotor Control Center, the Central Complex. Journal of Comparative Neurology 521, 2645-2662. doi: 10.1002/cne.23339.
  13. .Yu, H.H., Awasaki, T., Schroeder, M. D., Long, F., Yang, J. S., He, Y., Ding, P., Kao, J.C., Wu, G.Y., Peng, H. and Lee, T. (2013). Clonal Development and Organization of the Adult Drosophila Central Brain. Current Biology 23, 633-643. doi: 10.1016/j.cub.2013.02.057.
  14. .Lin, S., Kao, C.F., Yu, H.H., Huang, Y. and Lee, T. (2012). Lineage Analysis of Drosophila Lateral Antennal Lobe Neurons Reveals Notch-dependent Binary Temporal Fate Decisions. PLOS Biology 10, e1001425. doi: 10.1371/journal.pbio. 1001425.
  15. .Kao, C.F., Yu, H.H., He, Y., Kao, J.C. and Lee, T. (2012). Hierarchical Deployment of Factors Regulating Temporal Fate in a Diverse Neuronal Lineage of the Drosophila Central Brain. Neuron 73, 677-684. doi: 10.1016/j.neuron.2011.12.018.
  16. Yu, H.H., Kao, C.F., He, Y., Ding P., Kao J.C. and Lee, T. (2010). A Complete Developmental Sequence of a Drosophila Neuronal Lineage as Revealed by Twin-spot MARCM. PLOS Biology 8, e1000461. doi: 10.1371/ journal.pbio.1000461.
  17. Lin, S., Lai, S.L., Yu, H.H., Chihara, T., Luo, L. and Lee, T. (2010). Lineage-specific Effects of Notch/Numb Signaling in Postembryonic Development of the Drosophila Brain. Development 137, 43-51. doi: 10.1242/ dev.041699.
  18. Yu, H.H., Chen, C.H., Shi, L., Huang, Y.L. and Lee, T. (2009). Twin-Spot MARCM to Reveal Developmental Origin and Identity of Neurons. Nature Neuroscience 12, 947-953. doi: 10.1038/nn.2345.
  19. Yu, H.H., Yang, J.S., Wang, J., Huang, Y. and Lee, T. (2009). Endodomain Diversity in Drosophila Dscam and its Roles in Neuronal Morphogenesis. Journal of Neuroscience 29, 1904-1914. doi: 10.1523/jneurosci. 5743-08.2009.
  20. Yu, H.H. and Lee T. (2007) Neuronal Temporal Identity in Post-embryonic Drosophila Brain. Trends in Neuroscience 30, 520-526. doi: 10.1016/j.tins.2007.07. 003.
  21. Shi, L., Yu, H.H., Yang, J.S., and Lee, T. (2007). Specific Drosophila Dscam Juxtamembrane Variants Control Dendritic Elaboration and Axonal Arborization. Journal of Neuroscience 27, 6723-6728. doi: 10. 1523/ jneurosci.1517-07.2007.
  22. Soba, P., Zhu, S., Emoto, K., Younger, S., Yang, S.J., Yu, H.H., Lee, T., Jan, L.Y., and Jan, Y.N. (2007). Drosophila Sensory Neurons Require Dscam for Dendritic Self-avoidance and Proper Dendritic Field Organization. Neuron 54, 403-416. doi: 10.1016/j.neuron.2007.03.029.