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Chen-Hui Chen|Institute of Cellular and Organismic Biology, Academia Sinica

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Professional ExperienceOpenClose
Associate Research Fellow, Institute of Cellular and Organismic Biology, Academia Sinica, Taiwan
Assistant Research Fellow, Institute of Cellular and Organismic Biology, Academia Sinica, Taiwan
Postdoctoral Fellow, Department of Cell Biology, Duke University Medical Center, USA
Ph.D. in Genetics, Dartmouth College, USA
Research InterestOpenClose

Some vertebrates, like salamanders and zebrafish, are able to regenerate complex tissues (e.g. the appendages, major organs, and spinal cord). Understanding how and why natural regeneration occurs in these vertebrates may transform medicine as we know it today. Finding answers to these two questions is the basis of my research program. 

We focus our efforts on key knowledge gaps that would be best addressed with the zebrafish model. We aim to combine large-scale cell imaging and genetics with systems-level analyses for uncovering the cellular and molecular mechanisms of regeneration. The long-term goal of my lab is to translate our findings for enhancing regenerative capacity of human tissues and organs

Selected PublicationOpenClose
  1. Skin cells undergo asynthetic fission to expand body surfaces in zebrafish. Chan KY, Yan CCS, Roan HY, Hsu SC, Tseng TL, Hsiao CD, Hsu CP, (Chen CH)*. Nature. 2022 May; 605(7908):119-125. PMID: 35477758 
  2. Whole-body clonal mapping identifies giant dominant clones in zebrafish skin epidermis. Roan HY, Tseng TL, (Chen CH)*. Development. 2021 Sep 15; 148(18): dev199669. PMID: 34463754
  3. The RNA helicase Ddx52 functions as a growth switch in juvenile zebrafish. Tseng TL, Wang YT, Tsao CY, Ke YT, Lee YC, Hsu HJ, Poss KD, (Chen CH)*. Development. 2021 Aug 1; 148(15): dev199578. PMID: 34323273
  4. Genetic Reprogramming of Positional Memory in a Regenerating Appendage. Wang YT, Tseng TL, Kuo YC, Yu JK, Su YH, Poss KD, (Chen CH)*. Current Biology. 2019 Dec 16; 29(24): 4193-4207.e4. PMID: 31786062
  5. Regeneration Genetics. (Chen CH)* and Poss KD. Annual Review of Genetics. 2017 Nov 27; 51:63-82. PMID: 28853919