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Stephan Q. Schneider|Institute of Cellular and Organismic Biology, Academia Sinica

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  • Stephan Q. Schneider
    Assistant Research Fellow
    • SpecialtyEvolutionary Cell & Developmental Biology, Molecular Evolution & Animal Phylogenetics Comparative Genomics
    • E-mailsqschneider@gate.sinica.edu.tw
    • Tel02-2789-9512
    • Website Dr. Stephan Schneider's Lab
    • LabR145/ICOB
Professional ExperienceOpenClose
Assistant Research Fellow, Institute of Cellular and Organismic Biology, Academia Sinica, Taipei, Taiwan
Assistant Professor, Department of Genetics, Development & Cell Biology, Iowa State University, Ames, IA, USA
Senior Research Associate, Institute of Molecular Biology, University of Oregon, Eugene, OR, USA
Postdoctoral Research Fellow, Institute of Molecular Biology, University of Oregon, Eugene, OR, USA
Junior Researcher, Institute of Molecular Biology in Eugene, Oregon and Kewalo Marine Laboratory, University of Hawaii, Honolulu, HI, USA
Postdoctoral Research Fellow, Department of Organismal Biology and Anatomy, University of Chicago, Chicago, IL, USA
Scientific Assistant, Max Planck-Institute for Developmental Biology, Tübingen, Germany
Ph.D., Department of Cell Biology, Max Planck-Institute for Developmental Biology & Eberhard Karls University, Tübingen, Germany
Diploma in Biology, Zoological Institute, Johannes-Gutenberg-University, Mainz, Germany
Research InterestOpenClose

Spiralians comprise one of the largest groups in the animal kingdom, yet much of its biology especially on the molecular level remains unknown. The research endeavors in my lab encompass fundamental processes of spiralian development and cellular differentiation. These include various events throughout the life cycle like the maternal to zygotic transition and gene regulatory network (GRN) regulation to determine cell fates and cell types in embryos and larvae. Focusing on core cellular mechanisms like asymmetric cell division and ciliogenesis, we utilize comparative genomic and molecular genetic analyses to gain insights into evolution and function of developmental and morphological features. 

  1. Signaling pathways and gene regulatory networks. Our current works are focused on Wnt/beta-catenin -and BMP pathways, and their link to cell lineages and cell fates. To understand how these pathways impinge on early GRNs we utilize embryonic perturbations to study genome-wide responses by stage-specific and single cell transcriptomics.
  2. Ciliogenesis and ciliary cell types. Spiralians are champions of motile ciliary diversity. To exploit this diversity we identify the molecular components of the ciliary machinery, the ciliome, in a broader range of spiralians.  Complementary we put our lab model system, the marine annelid Platynereis dumerilii, to work to understand development and differentiation of ciliary cell types. 
  3. During the last decade Platynereis dumerilii emerged as the most advanced spiralian model enabling the molecular dissection of unique aspects of spiralian biology like asymmetric cell division and cilia-based larval motility. As part of the international Platynereis community we develop various resources and techniques like PdumBase, a research tool to study gene expression throughout the life cycle.
Selected PublicationOpenClose
  1. Özpolat, B.D., Randel, N., Williams, E.A., Bezares-Calderón, L.A., Andreatta, G., Balavoine, G., Ferrier, D.E.K., Gambi, M.C.., Gazave, E., Handberg-Thorsager, M., Hardege, J., Hird, C., Hsieh, Y-W., Mutemi, K.N., Schneider, S.Q., Simakov, O., Vervoort, M., Jékely G., Tessmar-Raible, K., Raible, F., Arendt, D. (2021) The nereid on the rise: Platynereis as a model system. EvoDevo (1):10, 1-22.
  2. Wu, L., Hiebert, L.S., Klann, M., Passamaneck, Y., Bastin, B.R., Schneider, S.Q., Martindale, M.Q., Seaver, E.C., Maslakova, S.A., and Lambert, J.D. (2020) Genes with spiralian-specific protein motifs are expressed in spiralian ciliary bands. Nature Communications, 11:4171, 1-11. 
  3. Bastin, B.R. , and Schneider, S.Q. (2019) Taxon-specific expansion and loss of tektins inform metazoan ciliary diversity. BMC Evolutionary Biology, 19(1):40. 1-25. doi: 10.1186/s12862-019-1360-0
  4. Chou, H.-C. , Acevedo-Luna, N. , Kuhlman, J.A., and Schneider, S.Q. (2018) PdumBase: A transcriptome database and research tool for Platynereis dumerilii and early development of other metazoans. BMC Genomics, 19(1):618. 
  5. Nakama, A., Chou, H.-C., and Schneider, S.Q. (2017) The asymmetric cell division machinery in the spiral-cleaving egg and embryo of the marine annelid Platynereis dumerilii. BMC Developmental Biology, 17:16. 1-22. https://doi.org/10.1186/s12861-017-0158-9 (BMC series blog: top three articles of 2017) 
  6. Roy, S., Natakunda, K., Chou, H.-C., Pal, N., Farris, C., Schneider, S.Q., and Kuhlman, J.A. (2017) Defining the transcriptomic landscape of the developing enteric nervous system and its cellular environment. BMC Genomics, 18(1): 290.1-24.
  7. Chou, H.-C., Pruitt, M.M., Bastin, B.R., and Schneider, S.Q. (2016) A transcriptional blueprint for a spiral-cleaving embryo. BMC Genomics, 17:552.1-25. doi:10.1186/s12864-016-2860-6 [reviewed in Blum & Ott (2018) Current Biology, 28] 
  8. Bastin, B.R., Chou, H.-C., Pruitt, M.M., and Schneider, S.Q. (2015) Structure, phylogeny and expression of the Frizzled related gene family in the lophotrochozoan annelid Platynereis dumerilii. EvoDevo. 6, 37, 1-24. 
  9. Pruitt, M.M., Letcher, E.J., Chou, H.-C., Bastin, B.R., and Schneider, S.Q. (2014) Temporal and spatial expression of the wnt gene complement in a spiral-cleaving embryo and trochophore larva. Special Issue ‘Spiralian Model Systems’. Int J Dev Biol. 58(6-7-8): 563-573. 
  10. Schneider, S.Q. and Bowerman, B.A. (2013) Animal development: An ancient beta-catenin switch? Current Biology, 23, R313-5.