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Chi-Hon Lee|Institute of Cellular and Organismic Biology, Academia Sinica

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  • Chi-Hon Lee
    Distinguished Research Fellow & Director
    • Specialtyneuroscience
    • E-mailleechih@gate.sinica.edu.tw
    • Tel02-2789-9501
    • Website Chi-Hon Lee Lab
    • LabR530/ICOB
Professional ExperienceOpenClose
Director, Institute of Cellular and Organismic Biology, Academia Sinica
Distinguished Research Fellow, Institute of Cellular and Organismic Biology, Academia Sinica
2009- 2018
Senior Investigator, NICHD/NIH
2006- 2018
Adjunct Professor, BISI/University of Maryland
2002- 2009
Investigator, NICHD/NIH
1997- 2002
Postdoctoral Fellow, UCLA/HHMI
Ph.D. degree, Biophysics, Rockefeller Universi
Research InterestOpenClose

Using the Drosophila visual system as a model, we study how neurons form complex yet stereotyped synaptic connections during development and how the assembled neural circuits extract visual attributes, such as color and motion, to guide animal behaviors. To study visual circuit functions, we combine structural and functional approaches to map visual circuits. With targeted manipulation of neuronal activity, we identified specific neurons that are functionally required for color-driven behaviors. Using both light- and electron-microscopy (EM) studies, we mapped the neurons' synaptic circuits. For circuit development, we focus on the formation of synaptic connections between the chromatic photoreceptors and their synaptic partners in the medulla neuropil. We used high-resolution imaging techniques and genetic manipulations to delineate the molecular mechanisms that control dendritic patterning and synaptic specificity of the medulla neurons.

Selected PublicationOpenClose
  • Li, Y., Chen, P.-J., Lin, T.-Y., Ting, C.-Y., Muthuirulan, P., Pursley, R., Ilić, M., Pirih, P., Drews, M., Menon, K. P., Zinn, K. G., Pohida, T., Borst, A., and  Lee, C.-H. (2021) Neural Mechanism of Spatio-chromatic Opponency in the Drosophila Amacrine Neurons. Curr Biol. Jul 26;31(14):3040-3052.e9. doi: 10.1016/j.cub.2021.04.068
  • Luo, J., Ting, C.-Y., Li, Y., McQueen, P. G., Lin, T.-Y., Hsu, C. P., and Lee, C.-H.  (2020) Antagonistic Regulation by Insulin-like Peptide and Activin Ensures the Elaboration of Appropriate Dendritic Field Sizes of Amacrine Neurons. eLife 2020:9:e50568. doi: 10.7554/eLife.50568
  • Song, B.-M., and Lee, C.-H. (2018) Toward a Mechanistic Understanding of Color Vision in Insects. Front. Neural Circuits 12:16. doi: 10.3389/fncir.2018.00016
  • Li, Y., Dharkar, P., Han, T.-H., Serpe, M., Lee, C.-H., Mayer, M.L. (2016) Novel Functional Properties of Drosophila CNS Glutamate Receptors. Neuron 92: 1036–1048.
  • Lin, T.-Y., Luo, J., Shinomiya, K., Ting, C.-Y., Lu, Z., Meinerzhagen. I.A., and Lee, C.-H. (2016) Mapping Chromatic Pathways in the Drosophila Visual System. J Comp Neurol. 524:213-227.
  • Melnattur, K.V., Pursley, R., Lin, T.-Y., Ting, C.-Y., Smith, P.D., Pohida, T. and Lee, C.-H. (2014) Multiple Redundant Medulla Projection Neurons Mediate Color Vision in Drosophila. J. Neurogenetics. 28:374-388.
  • Karuppudurai, T., Lin, T.-Y., Ting, C.-Y., Pursley. R., Melnattur, K. V., Diao, F., White, B. H., Macpherson, L. J., Gallio,M., Pohida, T. and Lee, C.-H. (2014) A Hard-wired Glutamatergic Circuit Pools and Relays UV Signals to Mediate Spectral Preference in Drosophila. Neuron 81: 603-615.
  • Ting, C.-Y., McQueen, P. G., Pandya, N., Lin, T.-Y., Yang, M., Reddy, O. V., O’Connor, M. B., McAuliffe, M. and Lee, C.-H. (2014) Photoreceptor-Derived Activin Promotes Dendritic Termination and Restricts the Receptive Fields of First-Order Interneurons in Drosophila. Neuron 81: 830-46.
  • Gao, S., Takemura, S.-y., Ting, C.-Y., Huang, S., Lu, Z., Luan, H., Rister, J., Thum, A. S., Yang, M., Hong, S.-T., Wang, J.W., Odenwald, W.F., White, B.H., Meinertzhagen, I.A., Lee, C.-H. (2008) The Neural Substrate of Spectral Preference in Drosophila. Neuron 60, 328-42.
  • Ting, C.-Y., Herman, T., Yonekura S., Gao, S., Wang, J., Serpe, M., O'Connor, M.B., Zipursky, S.L., Lee, C.-H. (2007) Tiling of R7 axons in the Drosophila visual system is mediated both by transduction of an Activin signal to the nucleus and by mutual repulsion. Neuron 56: 793-806.