Go to the content anchor

Jr-Kai Yu|Institute of Cellular and Organismic Biology, Academia Sinica

Faculty
:::
aside menu open Faculty
:::

Article content area

  • Jr-Kai Yu
    Associate Research Fellow & MRS Chief
    • SpecialtyDevelopmental Biology, Evolution of Development
    • E-maijkyu@gate.sinica.edu.tw
    • Tel02-2787-1516, 03-9880544 ext 17
    • Website Jr-Kai Yu's Lab
    • LabR403/ICOB
Professional ExperienceOpenClose
2016
Associate Research Fellow, Institute of Cellular and Organismic Biology, Academia Sinica
2007-2016
Assistant Research Fellow, Institute of Cellular and Organismic Biology, Academia Sinica
2005-2007
Postdoctoral Scholar, Division of Biology, California Institute of Technology, USA.
2005
Postdoctoral research fellow, Marine Biology Research Division, Scripps Institution of Oceanography, University of California, San Diego, USA.
2005
Ph.D., Marine Biology Research Division, Scripps Institution of Oceanography, University of California, San Diego, USA
Research InterestOpenClose

My research is focused on the evolution of developmental mechanisms. I am interested in the origins of chordate and vertebrate novel characters, particularly in understanding the developmental and genomic changes that may have led to the emergence of these innovations. My research team mainly uses cephalochordates (Amphioxus) as our model organism. Amphioxus represent an early-branching chordate group and thus occupy a key phylogenetic position for understanding the possible characters in the proximate invertebrate ancestor of the vertebrates. We apply comparative genomics/transcriptomics and molecular developmental analyses to investigate the key evolutionary changes during the invertebrate-to-vertebrate transition. This transition represents one of the most significant events in the history of life; however, many questions surrounding how vertebrate innovations may have emerged remain unanswered. In collaboration with other researchers, I also extend my research program to other invertebrate deuterostome animals, including hemichordates and echinoderms. The long-term goal of my research program is to understand the genomic and developmental basis underlying the evolution of the distinct body plans of major deuterostome phyla.

Selected PublicationOpenClose
  1. Yong LW, Lu TM, Tung CH, Chiou RJ, Li KL, & Yu JK* (2021) Somite compartments in amphioxus and its implications on the evolution of the vertebrate skeletal tissues. Front Cell Dev Biol 9:607057.
  2. Lin CY, Yu JK*, & Su YH* (2021) Evidence for BMP-mediated specification of primordial germ cells in an indirect-developing hemichordate. Evol & Dev 2021 23:28-45.
  3. Lin CY, Lu MYJ, Yue JX, Li KL. Le Pétillon Y, Yong LW, Chen YH, Tsai FU, Lyu YF, Chen CY, Hwang SPL, Su YH*, & Yu JK* (2020) Molecular asymmetry in the cephalochordate embryo revealed by single-blastomere transcriptome profiling. PLOS Genetics 16:e1009294.
  4. Simakov O*, Marletaz F, Yue JX, O'Connell B, Jenkins J, Brandt A, Calef R, Tung CH, Huang TK, Schmutz J, Satoh N, Yu JK, Putnam NH, Green RE, & Rokhsar DS* (2020). Deeply conserved synteny resolves early events in vertebrate evolution. Nat Ecol Evol 4:820-830. 
  5. Su YH*, Chen YC, Ting HC, Fan TP, Lin CY, Wang KT, & Yu JK* (2019). BMP controls dorsoventral and neural patterning in indirect-developing hemichordates providing insight into a possible origin of chordates. Proc Natl Acad Sci USA 116:12925-12932. 
  6. Kawaguchi M, Sugiyama K, Matsubara K, Lin CY, Kuraku S, Hashimoto S, Suwa Y, Yong LW, Takino K, Higashida S, Kawamura D, Yu JK & Seki Y*(2019) Co-option of the PRDM14–CBFA2T complex from motor neurons to pluripotent cells during vertebrate evolution. Development 146: dev168633.
  7. Marletaz F, Firbas PN, Maeso I*, Tena JJ, Bogdanovic O, Perry M, Wyatt CDR, de la Calle-Mustienes E, Bertrand S, Burguera D, Acemel RD, van Heeringen SJ, Naranjo S, Herrera-Ubeda C, Skvortsova K, Jimenez-Gancedo S, Aldea D, Marquez Y, Buono L, Kozmikova I, Permanyer J, Louis A, Albuixech-Crespo B, Le Petillon Y, Leon A, Subirana L, Balwierz PJ, Duckett PE, Farahani E, Aury JM, Mangenot S, Wincker P, Albalat R, Benito-Gutierrez E, Canestro C, Castro F, D'Aniello S, Ferrier DEK, Huang S, Laudet V, Marais GAB, Pontarotti P, Schubert M, Seitz H, Somorjai I, Takahashi T, Mirabeau O, Xu A, Yu JK, Carninci P, Martinez-Morales JR, Crollius HR, Kozmik Z, Weirauch MT, Garcia-Fernandez J, Lister R, Lenhard B, Holland PWH, Escriva H*, Gomez-Skarmeta JL*, & Irimia M* (2018) Amphioxus functional genomics and the origins of vertebrate gene regulation. Nature. 564:64-70. 
  8. Nakashima K*, Kimura S, Ogawa Y, Watanabe S, Soma S, Kaneko T, Yamada L, Sawada H, Tung CH, Lu TM, Yu JK, Villar-Briones A, Kikuchi S, & Satoh N (2018) Chitin-based barrier immunity and its loss predated mucus-colonization by indigenous gut microbiota. Nat Commun 9(1):3402.
  9. Hu H, Uesaka M, Guo S, Shimai K, Lu TM, Li F, Fujimoto S, Ishikawa M, Liu S, Sasagawa Y, Zhang G, Kuratani S, Yu JK, Kusakabe TG, Khaitovich P, Irie N*, and the EXPANDE Consortium (2017) Constrained vertebrate evolution by pleiotropic genes. Nat Ecol Evol 1:1722-1730.
  10. Yong LW, & Yu JK* (2016) Tracing the evolutionary origin of vertebrate skeletal tissues: insights from cephalochordate amphioxus. Curr Opin Genet Dev, 39:55-62