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Tsai-Ming Lu|Institute of Cellular and Organismic Biology, Academia Sinica

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  • Tsai-Ming Lu
    Assistant Research Scientist
    • SpecialtyComparative Genomics & Transcriptomics, Phylogenomics, NGS data analysis
    • E-maitmlu@gate.sinica.edu.tw
    • Tel02-2789-9532
    • Website Bioinformatics Core Laboratory
    • LabR518/ICOB
Professional ExperienceOpenClose
Assistant Research Scientist, Institute of Cellular and Organismic Biology, Academia Sinica, Taiwan
Postdoctoral Research Fellow, Comparative Developmental Biology Group, Department of Biological Sciences, University of Bergen, Norway
JSPS Postdoctoral Fellow, Okinawa Institute of Science and Technology Graduate University, Japan
Ph.D., in Marine Genomics, Okinawa Institute of Science and Technology Graduate University, Japan
Research InterestOpenClose

1.Molecular mechanism and evolution of cell differentiation
A dicyemid individual consists of around 30 cells, and their developmental lineages have been well studied. Due to the extraordinary simplification of body organization, some cells in dicyemid seem to possess multiple functions. Thus, we use dicyemid as an animal model to study the molecular mechanism and evolution of cell type differentiation by single-cell sequencing technology.

2.The Xenacoelomorpha genome project
The phylogenetic position of the Xenacoelomorpha is still a matter of debate in the study of animal evolution. By comparative genomic studies, we aim to discover genomic evidence to provide insights into the evolutionary status of the Xenacoelomorpha.

Selected PublicationOpenClose
  1. Orús-Alcalde A, Lu TM, Børve A and Hejnol A (2021) The evolution of the metazoan Toll receptor family and its expression during protostome development. BMC Ecology and Evolution 21:208.
  2. Yong LW, Lu TM, Tung CH, Chiou RJ, Li KL and Yu JK (2021) Somite Compartments in amphioxus and its implications on the evolution of the vertebrate skeletal tissues. Front. Cell Dev. Biol. 9:607057. 
  3. Lu TM, Furuya H and Satoh N (2019) Gene expression profiles of dicyemid life-cycle stages may explain how dispersing larvae locate new hosts. Zoological Letters 5:32.
  4. Lu TM, Kanda M, Furuya H and Satoh N (2019) Dicyemid mesozoans: a unique parasitic lifestyle with reduced genome. Genome Biology and Evolution 11: 2232-2243.
  5. Guzman C, Shinzato C, Lu TM and Conaco C (2018) Transcriptome analysis of the reef-building octocoral, Heliopora coerulea. Scientific Reports 8: 8397.
  6. Hu H, Uesaka M, Guo S, Shimai K, Lu TM, Li F, Fujimoto S, Ishikawa M, Liu S, Sasagawa Y, Zhang G, Kuratani S, Yu JK, Kusakabe TG, Khaitovich P, Irie N and EXPANDE Consortium (2017) Constrained vertebrate evolution by pleiotropic genes. Nature Ecology & Evolution 1: 1722-1730.
  7. Lu TM, Kanda M, Satoh N and Furuya H (2017) The phylogenetic position of dicyemid mesozoans offers insights into spiralian evolution. Zoological Letters 3:6.
  8. Soukup V, Yong LW, Lu TM, Huang SW, Kozmik Z and Yu JK (2015) The Nodal signaling pathway controls left-right asymmetric development in amphioxus. EvoDevo 6:5. 
  9. Li KL, Lu TM and Yu JK (2014) Genome-wide survey and expression analysis of the bHLH-PAS genes in the amphioxus Branchiostoma floridae reveal both conserved and diverged expression patterns between cephalochordates and vertebrates. EvoDevo 5:20.
  10. Lu TM, Luo YJ and Yu JK (2012) BMP and Delta/Notch signaling control the development of amphioxus epidermal sensory neurons: insights into the evolution of the peripheral sensory system. Development 139: 2020-2030.