丘淑鈴老師實驗室 丘淑鈴Shu-Ling Chiu 助研究員Assistant Research Fellow 專長:Synaptic Plasticity, Neural Development, Learning and Memory 信箱:slchiu@gate.sinica.edu.tw 電話:02-2789-9536 位置:R510/ICOB 友善列印 展開社群分享 臉書 推特 LINE 實驗室簡介展開收合 我們實驗室致力於學習和記憶的分子/細胞機制研究。應用多元的專業技術 (包括電生理學,生物化學,細胞生物學,生物活體成像和動物行為學等),以及不同的實驗模式系統 (包括原生神經細胞和小鼠),我們希望能深入了解神經細胞是如何發育和整合到不同的迴路中以執行大腦的認知功能。我們特別感興趣的研究方向如下: 神經細胞如何在發育過程中建立正確的連結和大腦迴路; 神經突觸可塑性 (synaptic plasticity) 如何影響動物的學習和記憶; 神經突觸失能(synaptic dysfunction) 如何導致智力障礙(Intellectually Disability)和自閉症症候群(Autism Spectrum Disorder) 等常見的人類大腦神經發育障礙。 榮譽獎項展開收合 2022 Career Development Award, Academia Sinica, Taiwan (中研院前瞻研究計畫) 2021 Excellent Young Scholar Award, Ministry of Science & Technology, Taiwan (科技部2030跨世代年輕學者方案 - 優秀年輕學者獎) 2018 Young Investigator and Travel Award, SYNGAP1/Neurodevelopmental Disorder Therapies Meeting (NINDS-sponsored), Florida, USA 2016 Young Investigator and Travel Award, The International SYNGAP Conference (NINDS-sponsored), Texas, US 2012 NARSAD Young Investigator Grant, Brain & Behavior Research Foundation, USA 實驗室成員展開收合 姓名 職稱 電話 Email 備註 丘淑鈴 助研究員 2789-9536 slchiu@gate.sinica.edu.tw 2019.09~ 黃鈺閔 博士班研究生 2789-9553 yuminhuang.ls11@nycu.edu.tw 2022.09~ 賴亭瑋 研究助理 2789-9553 as0201137@gate.sinica.edu.tw 2022.08~ 許維宇 研究助理 2789-9553 walter8035@gate.sinica.edu.tw 2022.09~ 譚崇倫 研究助理 2789-9553 aaluntan@gate.sinica.edu.tw 2024.03~ 陳渝涵 研究助理 -- mila120745@gate.sinica.edu.tw 2022.07~ 2023.09 鍾之晴 研究助理 -- current: PhD student, TIGP-INS 2021.07~2024.08 楊雅惠 研究助理 -- current: RA, NDMC 2021.01~2023.09 蕭馥芸 研究助理 -- current: MS, NTUCM 2019.11-2020.11 金叡鑌 實習生 -- current: MS Student, U Lausanne, Switzerland 2020.08-2021.06 著作展開收合 Research Articles Chen C-M, Wu C-C, Kim Y, Hsu W-Y, Tsai Y-C#, Chiu S-L#. 2024 Enhancing social behavior in an autism spectrum disorder mouse model: investigating the underlying mechanims of Lactiplantibacillus plantarum interventions. Gut Microbes 16(1): 2359501 (# Correspondence) Chiu S-L*#, Chen C-M*, and Huganir RL#. 2023 ICA69 regulates activity-dependent synaptic strengthening and learning and memory. Front. Molecular Neuroscience (*: Equal contribution, # Correspondence) Tan HL*, Chiu S-L*, Zhu Q*, and Huganir RL. 2020. GRIP1 regulates synaptic plasticity and learning and memory. PNAS 117(40): 25085-25091 (*: Equal contribution) Mejias R, Chiu S-L, Han M, Rose R, Gil-Infante A, Zhao Y, Huganir RL, Wang T. 2019 Purkinje cell-specific Grip1/2 knockout mice show increased repetitive self-grooming and enhanced mGluR5 signaling in cerebellum. Neurobiol Dis. 132:104602 Wang Q, Chiu S-L*, Koropouli E*, Hong I*, Mitchell S, Easwaran TP, Hamilton N, Gustina A, Zhu Q, Ginty DD, Huganir RL, Kolodkin AL. 2017 Neuropilin-2/PlexinA3 receptors associate with GluA1 and mediate Sema3F-dependent homeostatic scaling in cortical neurons. Neuron 96(5): 1084-1098 (*: Equal contribution) Chiu S-L, Diering G, Ye B, Takamiya K, Jiang Y, Niranjan T, Schwartz CE, Wang T and Huganir RL. 2017 GRASP1 regulates synaptic plasticity and memory through endosomal recycling of AMPA receptors. Neuron 93(6): 1405-1419 Han M, Mejias R, Chiu S-L, Rose R, Adamczyk, A, Huganir RL and Wang T. 2017 Mice lacking GRIP1/2 show increased social interactions and enhanced phosphorylations at GluA2-S880. Behavioural Brain Research 321: 176-84 Chen C-M, Orefice L*, Chiu S-L*, LeGates T, Hattar S, Huganir RL, Zhao H, Xu B and Kuruvilla R. 2017 Wnt5a is essential for hippocampal dendritic maintenance and spatial learning and memory in adult mice. PNAS 114(4): E619-28 (*: Equal contribution) Gu Y, Chiu S-L, Liu B, Wu PH, Delannoy M, Lin DT, Wirtz D and Huganir RL. 2016 Differential vesicular sorting of AMPA and GABAA receptors. PNAS 113 (7): E922-31 Zhang K, Donnelly CJ, Haeusler AR, Grima JC, Machamer JB, Steinwald P, Daley EL, Miller SJ, Cunningham KM, Vidensky S, Gupta S, Thomas MA, Hong I, Chiu S-L, Huganir RL, Ostrow LW, Matunis MJ, Wang J, Sattler R, Lloyd TE, Rothstein JD. 2015 The C9orf72 repeat expansion disrupts nucleocytoplasmic transport. Nature 525(7567): 56-61 Thomas GM, Hayashi T, Chiu S-L, Chen CM and Huganir RL. 2012 Palmitoylation by DHHC5/8 targets GRIP to dendritic endosomes to regulate AMPA-R trafficking. Neuron 73(3): 482-96 Li J, Wang Y, Chiu S-L, Cline HT. 2010. Membrane targeted horseradish peroxidase as a marker for correlative fluorescence and electron microscopy studies. Front. Neural Circuits 26(4): 6 Chen C-M*, Chiu S-L*, Cline HT. 2009. Co-expression of Argonaute2 enhances short hairpin RNA-induced RNA interference in Xenopus CNS neurons in vivo. Front. Neuroscience 9(3):63. ( *: Equal contribution) Chiu S-L, Chen CM, Cline HT. 2008. Insulin receptor signaling regulates synapse number, dendritic plasticity and circuit function in vivo. Neuron 58(5): 708-719 Bestman JE*, Ewald RC*, Chiu S-L*, Cline HT. 2006. In vivo single-cell electroporation for transfer of DNA and macromolecules. Nature Protocols 1(3): 1267-1272 ( *: Equal contribution) Chiang A-S, Lin W-Y, Liu H-P, Pszczolkowski MA, Fu T-F, Chiu S-L, Holbrook GL. 2002. Insect NMDA receptors mediate juvenile hormone biosynthesis. PNAS 99(1): 37-44 Chiang A-S, Liu Y-C, Chiu S-L, Hu S-H, Huang C-Y, Hsieh C-H. 2001. Three-dimensional mapping of brain neuropils in the cockroach, Diploptera punctata. J. Comp. Neurol. 440: 1-11 Review Articles Volk L, Chiu S-L, Sharma K, Huganir RL. 2015. Glutamate synapses in human cognitive disorders. Annual Review of Neuroscience 38(1): 127-49 Chiu S-L and Cline HT. 2010. Insulin receptor signaling in the development of neuronal structure and function. 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