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研究人員|中央研究院 細胞與個體生物學研究所

研究人員
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側邊選單開關 研究人員
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Laboratory of Marine Eco-Evo-Devo

  • Vincent LaudetVincent Laudet
    合聘特聘研究員Distinguished Research Fellow
    • 專長:Developmental Biology, Evolutionary Sciences, Ecology of Coral Reef Fish
    • 信箱:vincent.laudet@oist.jp
    • 電話:+81-80-9852-0005
      +886-3-988-0544 ext. 27
    • 網站: Vincent Laudet Lab
    • 位置:
實驗室簡介展開收合
Laboratory of Marine Eco-Evo-Devo Chromatic Circuits (共6張照片)

My team is interested in how hormones and their receptors play a role in evolutionary processes. To do so, we focus on thyroid hormones and their function in the control of metamorphosis. In amphibians thyroid hormones, combined with other hormones such as corticosteroids, have been shown to be essential for triggering and coordinating the transformation of the tadpole into a frog. In the lab, we use the extraordinary diversity of coral reef fish to better understand the role of hormones in the evolution of life history strategies, in a perspective integrating ecological, evolutionary and developmental components. Most coral reef fish exhibit a biphasic life cycle with a pelagic larva that ultimately transform into a reef associated juvenile. We have shown that TH controls one of the most salient features of metamorphosis: the development of the extraordinarily variable pigmentation pattern of the reef-associated fish.

The ca. 30 species of clownfish display a relatively simple color pattern made of zero to three white bars well visible on a darker body background. We have studied the ontogenesis and phylogenesis of these bars and revealed their role in species recognition. Overall, this illustrates how developmental and ecological processes have shaped the diversification of color patterns during the radiation of this lineage. Our recent results show that thyroid hormones control the development of the white bars. Our goal is to understand how this control is achieved mechanistically. We combine developmental, transcriptomic and genetic analyses to better understand how the thyroid hormones signaling pathway controls pigment cell differentiation and behavior.

We also work a lot to develop the anemone fish as marine model species since a marine teleost fish species is still lacking as a convenient model organism suitable for laboratory experiments in Eco-Evo-Devo. Marine teleost species used for research purposes are mostly aquaculture models (sea bass, sea bream, salmon, flatfish, tuna and grouper). Unfortunately, the size of adult individuals and the difficulty in raising these fishes in laboratory settings make them quite difficult to use. On the contrary, due to their remarkable biological traits the anemone fishes allow to tackle a large set of scientific questions in several disciplines: ecology, developmental biology and evolutionary sciences. We are therefore developing new method to improve the use of these fish as models.

The lab is joined to the Marine Eco-Evo-Devo unit at Okinawa Institute of Science and Technology (https://groups.oist.jp/meedu) in which I am Faculty. Both sites share models, biological questions, reagents, lab meetings and a lot of friendship!

實驗室成員展開收合
姓名 職稱 電話 Email 備註
韋思冕 博士後研究 03-9880544ext.13 svianello22@gate.sinica.edu.tw
李淑華 研究助理 03-9880544ext.13 fiona@gate.sinica.edu.tw
吳思楷 研究助理 03-9880544ext.13 as0210476@gate.sinica.edu.tw
著作展開收合
  1. Holzer G, Besson M, Lambert A, François L, Barth P, Gillet B, Hughes S, Piganeau G, Leulier F, Viriot L, Lecchini D Laudet V. Larval fish recruitment to reefs is a thyroid hormone-mediated metamorphosis sensitive to the pesticide chlorpyrifos. eLife, 2017 30: 6. pii: e27595.

  2. Salis P, Roux N, Soulat O, Lecchini D, Laudet V. Frederich B. Ontogenetic and phylogenetic simplification during white stripe evolution in clownfishes. BMC Biology, 2018 16: 90.

  3. Salis P, Lorin T, Laudet V, Frédérich B. Magic Traits in Magic Fish: Understanding Color Pattern Evolution Using Reef Fish. Trends in Genetics. 2019, 35: 265-278

  4. Salis P, Lorin T, Lewis V, Rey C, Marcionetti A, Escande ML, Roux N, Besseau L, Salamin N, Sémon M, Parichy D, Volff JN, Laudet V. Developmental and comparative transcriptomic identification of iridophore contribution to white barring in clownfish. Pigment Cell & Melanoma Research. 2019 32: 391-402.

  5. Roux N, Salis P, Lambert A, Logeux V, Soulat O, Frederich B, Lecchini D and Laudet V. Staging and normal table of post-embryonic development of the clownfish (Amphiprion ocellaris). Developmental Dynamics, 2019, 248: 545-568.

  6. Roux N, Lami R, Salis P, Magré, K, Romans P, Masanet P, Lecchini D and Laudet V. Sea anemone and clownfish microbiota diversity and variation at the initial steps of the symbiosis. Scientific Reports. 2019, 9: 19491.

  7. Besson M, Feeney WE, Moniz I, François L, Brooker RM, Holzer G, Metian M, Roux N, Laudet V, and Lecchini D. Anthropogenic stressors impact fish sensory development and survival via thyroid disruption. Nature Communication, 2020 11: 3614.