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研究人員｜中央研究院 細胞與個體生物學研究所

研究人員
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側邊選單開關 研究人員
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游宏祥之神經科學實驗室

  • 游宏祥Hung-Hsiang Yu
    副研究員Associate Research Fellow
    • 專長：Neural Development, Neuroscience
    • 信箱：samhhyu@gate.sinica.edu.tw
    • 電話：02-2787-1546
    • 位置：R334/ICOB
友善列印
實驗室簡介展開收合

動物利用散佈在周遭環境的味道來尋找食物，挑選伴侶和躲避敵人。因此發育過程中，建構正確的嗅覺神經網路，對動物的生存極其重要。在果蠅嗅覺神經網路內，同類的嗅覺感覺神經元(olfactory sensory neuron/OSNs)偵測到嗅覺分子後，將訊號經傳入大腦嗅葉(antennal lobe/AL)上的單一嗅球(glomerulus)，再由嗅覺投射神經元(projection neuron/PNs)傳到大腦的蘑菇體(mushroom body)及側角組織(lateral horn)。我們實驗室研究嗅覺投射神經元及蘑菇體神經元在發育過程中是如何建構嗅覺神經網路。我們發現，穿膜蛋白Semaphorin-1a (Sema-1a)對建構果蠅成蟲具有功能的嗅覺神經網路，有著不可或缺的角色。我們將進一步研究與Sema-1a相關的細胞及分子機制是如何來調控此精確的嗅覺圖譜的建構。另外，我們也將研究在細胞及分子層次上，如何正確調控蘑菇體神經元的命運特化及大範圍的軸突修剪，此對建構果蠅成蟲的正確嗅覺神經網路，亦扮演著至關重要的角色。

實驗室成員展開收合
姓名 職稱 電話 Email 備註
游宏祥 副研究員 02-2787-1546 samhhyu@gate.sinica.edu.tw
璩劭宇 研究助理 02-2787-1545 fantasy0879@gate.sinica.edu.tw
古凱元 研究助理 02-2787-1545 ej3d93m06@gmail.com
著作展開收合
  1. Lai, Y.W., Miyares, R.L., Liu, L.Y., Chu, S.Y., Lee, T. and Yu, H.H. (2022). Hormone-controlled changes in the differentiation state of post-mitotic neurons. Current Biology 32, 2341-2348. doi: 10.1016/j.cub. 2022.04.027.
  2. Wei, J.Y., Chu, S.Y., Hung, Y.C., Chung, P.C. and Yu, H.H. (2022). Drosophila septin interacting protein 1 regulates neurogenesis in the early developing larval brain. Scientific Reports, 12 (1): 292. doi: 10.1038/ s41598-021-04474-3.
  3. Lin, T.Y., Chen, J.P., Yu, H.H., Hsu C.P. and Lee, C.H. (2021). Extrinsic factors regulating dendritic patterning. Front. Cell. Neuroscience, 14, 622808. doi: 10.3389/ fncel.2020.622808.
  4. Garcia-Marques, J., Espinosa-Medina, I., Ku, K.Y., Yang, C.P., Koyama, M., Yu, H.H. and Lee, T. (2020).  A programmable sequence of reporters for lineage analysis. Nature Neuroscience, 23: 1618-1628. doi: 10. 1038/s41593-020-0676-9.
  5. Lai, Y.W., Chu, S.Y., Li, J.C., Chen, P.L., Chen, C.H. and Yu, H.H. (2020).  Visualization of Endogenous Type I TGF-β Receptor Baboon in the Drosophila Brain. Scientific Reports 10 (1): 5153. doi: 10.1038/s41598-020-61950-y.
  6. Hsu, T.C., Ku, K.Y., Shen, H.C. and Yu, H.H. (2020). Overview of MARCM-related technologies in Drosophila neurobiological research. Current Protocols in Neuroscience, 91, e90. doi: 10.1002/cpns.90.
  7. Wei, J.Y., Chung, P.C., Chu, S.Y., and Yu, H.H. (2019). FOXO Regulates Cell Fate Specification of Drosophila Ventral Olfactory Projection Neurons. Journal of Neurogenetics, 33(1): 33-40.  doi: 10.1080/01677063. 2018.1556651.
  8. Shen, H.C., Chu, S.Y., Hsu, T.C., Wang, C.H., Lin, I.Y. and Yu, H.H. (2017). Semaphorin-1a Prevents Drosophila Olfactory Projection Neuron Dendrites from Mis-targeting into Select Antennal Lobe Regions. PLOS Genetics 13(4): e1006751. doi: 10.1371/journal.pgen.1006751. 
  9. Shen, H.C., Hsu, T.C., Chung, P.C., and Yu, H.H. (2017). Cell Lineage Analyses and Gene Function Studies Using Twin-Spot MARCM. Journal of Visualized Experiments 121: 555278. doi: 10.3791/55278.
  10. Lai, Y.W., Chu, S.Y., Wei, J.Y., Cheng, C.Y., Li, J.C., Chen, P.L., Chen, C.H. and Yu, H.H. (2016). Drosophila microRNA-34 Impairs Axon Pruning of Mushroom Body γ Neurons by Downregulating the Expression of Ecdysone Receptor. Scientific Reports 6: 39141. doi: 10.1038/srep39141.
  11. .Shen, H.C., Wei, J.Y., Chu, S.Y., Chung, P.C., Hsu, T.C. and Yu, H.H. (2016). Morphogenetic Studies of the Drosophila DA1 Ventral Olfactory Projection Neuron. PLOS One 11 (5): e0155384. doi: 10.1371/journal. pone.0155384.
  12. .Yang, J.S., Awasaki, T., Yu, H.H., He, Y., Ding, P., Kao, J.C. and Lee, T. (2013). Diverse Neuronal Lineages Make Stereotyped Contributions to the Drosophila Locomotor Control Center, the Central Complex. Journal of Comparative Neurology 521, 2645-2662. doi: 10.1002/cne.23339.
  13. .Yu, H.H., Awasaki, T., Schroeder, M. D., Long, F., Yang, J. S., He, Y., Ding, P., Kao, J.C., Wu, G.Y., Peng, H. and Lee, T. (2013). Clonal Development and Organization of the Adult Drosophila Central Brain. Current Biology 23, 633-643. doi: 10.1016/j.cub.2013.02.057.
  14. .Lin, S., Kao, C.F., Yu, H.H., Huang, Y. and Lee, T. (2012). Lineage Analysis of Drosophila Lateral Antennal Lobe Neurons Reveals Notch-dependent Binary Temporal Fate Decisions. PLOS Biology 10, e1001425. doi: 10.1371/journal.pbio. 1001425.
  15. .Kao, C.F., Yu, H.H., He, Y., Kao, J.C. and Lee, T. (2012). Hierarchical Deployment of Factors Regulating Temporal Fate in a Diverse Neuronal Lineage of the Drosophila Central Brain. Neuron 73, 677-684. doi: 10.1016/j.neuron.2011.12.018.
  16. Yu, H.H., Kao, C.F., He, Y., Ding P., Kao J.C. and Lee, T. (2010). A Complete Developmental Sequence of a Drosophila Neuronal Lineage as Revealed by Twin-spot MARCM. PLOS Biology 8, e1000461. doi: 10.1371/ journal.pbio.1000461.
  17. Lin, S., Lai, S.L., Yu, H.H., Chihara, T., Luo, L. and Lee, T. (2010). Lineage-specific Effects of Notch/Numb Signaling in Postembryonic Development of the Drosophila Brain. Development 137, 43-51. doi: 10.1242/ dev.041699.
  18. Yu, H.H., Chen, C.H., Shi, L., Huang, Y.L. and Lee, T. (2009). Twin-Spot MARCM to Reveal Developmental Origin and Identity of Neurons. Nature Neuroscience 12, 947-953. doi: 10.1038/nn.2345.
  19. Yu, H.H., Yang, J.S., Wang, J., Huang, Y. and Lee, T. (2009). Endodomain Diversity in Drosophila Dscam and its Roles in Neuronal Morphogenesis. Journal of Neuroscience 29, 1904-1914. doi: 10.1523/jneurosci. 5743-08.2009.
  20. Yu, H.H. and Lee T. (2007) Neuronal Temporal Identity in Post-embryonic Drosophila Brain. Trends in Neuroscience 30, 520-526. doi: 10.1016/j.tins.2007.07. 003.
  21. Shi, L., Yu, H.H., Yang, J.S., and Lee, T. (2007). Specific Drosophila Dscam Juxtamembrane Variants Control Dendritic Elaboration and Axonal Arborization. Journal of Neuroscience 27, 6723-6728. doi: 10. 1523/ jneurosci.1517-07.2007.
  22. Soba, P., Zhu, S., Emoto, K., Younger, S., Yang, S.J., Yu, H.H., Lee, T., Jan, L.Y., and Jan, Y.N. (2007). Drosophila Sensory Neurons Require Dscam for Dendritic Self-avoidance and Proper Dendritic Field Organization. Neuron 54, 403-416. doi: 10.1016/j.neuron.2007.03.029.