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研究人員｜中央研究院 細胞與個體生物學研究所

研究人員
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側邊選單開關 研究人員
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  • 呂在明Tsai-Ming Lu
    研究助技師Assistant Research Scientist
    • 專長：Comparative Genomics & Transcriptomics, Phylogenomics, NGS data analysis
    • 信箱：tmlu@gate.sinica.edu.tw
    • 電話：02-2789-9532
    • 網站： 生物資訊核心實驗室
    • 位置：R518/ICOB
友善列印
經歷簡介展開收合
2021-
Assistant Research Scientist, Institute of Cellular and Organismic Biology, Academia Sinica, Taiwan
2018-2020
Postdoctoral Research Fellow, Comparative Developmental Biology Group, Department of Biological Sciences, University of Bergen, Norway
2018
JSPS Postdoctoral Fellow, Okinawa Institute of Science and Technology Graduate University, Japan
2018
Ph.D., in Marine Genomics, Okinawa Institute of Science and Technology Graduate University, Japan
研究方向展開收合

1.細胞分化調控機制及演化
我們以二胚蟲（dicyemid）為實驗材料，利用單細胞定序技術來進行 “細胞演化學” 的研究。雖然我們對二胚蟲胚胎發育的細胞分裂譜系已有所了解，但對其細胞種類及功能仍不清楚。將利用特異性基因表現來定義二胚蟲的細胞種類，並解析各細胞種類在分化過程中的基因表現、調控。再與其他動物群比較，進而瞭解特定細胞類群的分化機制及演化。

2.異無腔動物基因體計畫
異無腔動物（Xenacoelomorpha）在演化樹上的位置至今仍有爭議，我們希望透過比較基因體學的研究，來為異無腔動物的演化位階提供更多證據。

代表著作展開收合
  1. Orús-Alcalde A, Lu TM, Børve A and Hejnol A (2021) The evolution of the metazoan Toll receptor family and its expression during protostome development. BMC Ecology and Evolution 21:208.
  2. Yong LW, Lu TM, Tung CH, Chiou RJ, Li KL and Yu JK (2021) Somite Compartments in amphioxus and its implications on the evolution of the vertebrate skeletal tissues. Front. Cell Dev. Biol. 9:607057. 
  3. Lu TM, Furuya H and Satoh N (2019) Gene expression profiles of dicyemid life-cycle stages may explain how dispersing larvae locate new hosts. Zoological Letters 5:32.
  4. Lu TM, Kanda M, Furuya H and Satoh N (2019) Dicyemid mesozoans: a unique parasitic lifestyle with reduced genome. Genome Biology and Evolution 11: 2232-2243.
  5. Guzman C, Shinzato C, Lu TM and Conaco C (2018) Transcriptome analysis of the reef-building octocoral, Heliopora coerulea. Scientific Reports 8: 8397.
  6. Hu H, Uesaka M, Guo S, Shimai K, Lu TM, Li F, Fujimoto S, Ishikawa M, Liu S, Sasagawa Y, Zhang G, Kuratani S, Yu JK, Kusakabe TG, Khaitovich P, Irie N and EXPANDE Consortium (2017) Constrained vertebrate evolution by pleiotropic genes. Nature Ecology & Evolution 1: 1722-1730.
  7. Lu TM, Kanda M, Satoh N and Furuya H (2017) The phylogenetic position of dicyemid mesozoans offers insights into spiralian evolution. Zoological Letters 3:6.
  8. Soukup V, Yong LW, Lu TM, Huang SW, Kozmik Z and Yu JK (2015) The Nodal signaling pathway controls left-right asymmetric development in amphioxus. EvoDevo 6:5. 
  9. Li KL, Lu TM and Yu JK (2014) Genome-wide survey and expression analysis of the bHLH-PAS genes in the amphioxus Branchiostoma floridae reveal both conserved and diverged expression patterns between cephalochordates and vertebrates. EvoDevo 5:20.
  10. Lu TM, Luo YJ and Yu JK (2012) BMP and Delta/Notch signaling control the development of amphioxus epidermal sensory neurons: insights into the evolution of the peripheral sensory system. Development 139: 2020-2030.