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研究人員｜中央研究院 細胞與個體生物學研究所

研究人員
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側邊選單開關 研究人員
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  • 李宜靜Yi-Ching Lee
    副研究員Associate Research Fellow
    • 專長：Human Genetic Diseases, Developmental Biology
    • 信箱：yiching@gate.sinica.edu.tw
    • 電話：02-2787-1550
    • 網站： 李宜靜老師實驗室
    • 位置：R502/ICOB
友善列印
經歷簡介展開收合
2021
Associate Research Fellow, Institute of Cellular and Organismic Biology, Academia Sinica, Taiwan
2013-2021
Assistant Research Fellow, Institute of Cellular and Organismic Biology, Academia Sinica, Taiwan
2011-2013
Assistant Professor, Institute of Molecular Medicine, National Tsing Hua University, Hsinchu, Taiwan
2009-2011
Adjunct Assistant Professor, Institute of Integrated Medicine, China Medial University, Taichung, Taiwan
2006-2011
Postdoctoral Research Fellow and Group leader, National Center for Genome Medicine, Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan
2003-2006
Visiting Fellow, National Institute of Child Health& Human Development (NICHD), National Institutes of Health (NIH), Bethesda, MD.
2003
Ph.D., Graduate Institute of Life Science, National Defense University, Taipei, Taiwan
研究方向展開收合

 

複雜疾病的發展甚至罕見疾病的發展，同時受到遺傳、環境和生活方式因素共同影響。我們的研究致力於了解影響遺傳疾病風險和進展的遺傳因子，和遺傳因子與環境因子之間相互作用。這些研究將提供策略以預防或延緩遺傳疾病的發展，有助於個人化醫療開發。

利用族群研究來了解遺傳疾病遺傳因子和環境間相互作用，但仍然極具挑戰性。我們實驗室將從了解罕見疾病的致病基因和致病途徑開始，近一步了解影響發病途徑的環境因子，來研究相關的複雜遺傳疾病。

我們目前研究專注於結締組織疾病，因為許多老化常見疾病與結締組織有關，而且遺傳因子和以及飲食和生活習慣對這些疾病的發展有很大影響。包含心血管，骨骼，關節，代謝，癌症相關疾病。

代表著作展開收合
  1. Wagner BM, Robinson JW, Lin YW, Lee, Y.C., Kaci N, Legeai-Mallet L, Potter LR, 2021, “Prevention of guanylyl cyclase-B dephosphorylation rescues achondroplastic dwarfism.”, JCI insight, 6(9), e147832. 
  2. Jiang, C.L., Jen, W.P., Tsao, C.Y., Chang, L.C., Chen, C.H., Lee, Y.C.* (2020) Glucose Transporter 10 Modulates Adipogenesis via Ascorbic Acid-Mediated Pathway to Protect Mice Against Diet-Induced Metabolic Dysregulation., PLOS Genetics, 16, e1008823. 
  3. Jen, W.P., Chen, H.M., Lin, Y.S., Chern, Y. and Lee, Y.C.* (2020) Twist1 Plays an Anti-apoptotic Role in Mutant Huntingtin Expression Striatal Progenitor Cells. Mol Neurobiol, 57, 1688-1703. 
  4. Syu, Y.W., Lai, H.W., Jiang, C.L., Tsai, H.Y., Lin, C.C. and Lee, Y.C.* (2018) GLUT10 maintains the integrity of major arteries through regulation of redox homeostasis and mitochondrial function. Hum Mol Genet, 27, 307-321. 
  5. Lee, Y.C.,* Song, I.W., Pai, Y.J., Chen, S.D. and Chen, Y.T.* (2017) Knock-in human FGFR3 achondroplasia mutation as a mouse model for human skeletal dysplasia. Sci Rep, 7, 43220. 
  6. Ko, T.M., Kuo, H.C., Chang, J.S., Chen, S.P., Liu, Y.M., Chen, H.W., Tsai, F.J., Lee, Y.C., Chen, C.H., Wu, J.Y.* Chen, Y.T.* (2015) CXCL10/IP-10 is a biomarker and mediator for Kawasaki disease. Circ Res, 116, 876-883. 
  7. Chen, C.H., Lee, C.S., Lee, M.T., Ouyang, W.C., Chen, C.C., Chong, M.Y., Wu, J.Y., Tan, H.K., Lee, Y.C., et al., Chen YT*, Cheng AT* (2014) Variant GADL1 and response to lithium therapy in bipolar I disorder. N Engl J Med, 370, 119-128. 
  8. Lee, Y.C., Kuo, H.C., Chang, J.S., Chang, L.Y., Huang, L.M., Chen, M.R., Liang, C.D., Chi, H., Huang, F.Y., Lee, M.L., Huang, Y.C., Hwang, B., Chiu, N.C., Hwang, K.P., Lee, P.C., Chang, L.C., Liu, Y.M., Chen, Y.J., Chen, C.H., Chen, Y.T.*, Tsai, F.J.*, Wu, J.Y.* (2012) Two new susceptibility loci for Kawasaki disease identified through genome-wide association analysis. Nat Genet, 44, 522-525. 
  9. Khor, C.C.,  Davila, S.,  Breunis, W.B.,  Lee, Y.C.,  Shimizu, C., Wright, V.J., Yeung, R.S., Tan, D.E., Sim, K.S., Wang, J.J. Wong, T.Y.* (2011) Genome-wide association study identifies FCGR2A as a susceptibility locus for Kawasaki disease. Nat Genet, 43, 1241-1246. 
  10. Lee, Y.C., Huang, H.Y., Chang, C.J., Cheng, C.H. and Chen, Y.T.* (2010) Mitochondrial GLUT10 facilitates dehydroascorbic acid import and protects cells against oxidative stress: mechanistic insight into arterial tortuosity syndrome. Hum Mol Genet, 19, 3721-3733.