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側邊選單開關 研究人員
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  • Shu-Ling Chiu大頭照
    Shu-Ling Chiu Shu-Ling Chiu老師 Research ID Shu-Ling Chiu老師 ORCID
    Assistant Research Fellow
    • 專長：Synaptic Plasticity, Neural Development, Learning and Memory
    • 信箱：slchiu@gate.sinica.edu.tw
    • 電話：02-2789-9536
    • 網站： Shu-Ling Chiu's Lab
    • 位置：R510/ICOB
友善列印
經歷簡介展開收合
2019
Assistant Research Fellow, Institute of Cellular and Organismic Biology, Academia Sinica, Taiwan
2016-2019
Research Associate, The Johns Hopkins University School of Medicine, Maryland, USA
2008-2016
Postdoctoral Fellow, The Johns Hopkins University School of Medicine, Maryland, USA
2002-2008
Ph.D. program, Watson School of Biological Sciences, Cold Spring Harbor Laboratory, USA
研究方向展開收合

Our research interests and current focuses are:

1. Regulation of neurotransmitter receptor function
We are interested in the dynamic regulations of excitatory and inhibitory neurotransmitter receptors in the brain. We have found several key endosomal trafficking molecules that are essential for the expressions of AMPA and GABAA receptors on the membrane surface or at synapses, and demonstrated that dysregulated receptor trafficking influences synaptic transmission, synaptic plasticity and cognition in mice. We are studying how excitatory/inhibitory balance is regulated to maintain proper neuronal function and animal behavior. 

 2. Regulation of synapse development and maintenance
Synaptic connectivity is dynamic and determined by a balance among synapse formation, elimination and maintenance that continues throughout development into adulthood. In the visual and mouse hippocampal circuits, we have identified signaling pathways that are essential for specific regulations of synapse formation during development and synapse maintenance in adult age. Utilizing time-lapse imaging in culture neurons and two-photon imaging in living mice, we aim to gain insights into how neuronal activity and sensory/learning experience shape neuronal circuits in vivo and in real time.

3. Glutamatergic synapse function in neurodevelopmental disorders
Human genetic studies suggest that glutamatergic synapse structure and function are common underlying pathophysiology in developmental brain diseases. We have investigated several disease-associated genes and provided functional links between miss-regulated glutamate receptor function and neurocognitive disorders, including intellectual disability and autism spectrum disorder. We are investigating the underlying etiology in our disease mouse models with the ultimate goal to facilitate the development of therapeutic treatments for these disorders.

代表著作展開收合
1

Chiu S-L*#, Chen C-M*, and Huganir RL#. 2023. ICA69 regulates activity-dependent synaptic strengthening and learning and memory. Frontiers in Molecular Neuroscience (*: Equal contribution, # Correspondence)

2

Tan HL*, Chiu S-L*, Zhu Q*, and Huganir RL. 2020. GRIP1 regulates synaptic plasticity and learning and memory. Proc Natl Acad Sci USA 117(40): 25085-25091 (*: Equal contribution) Editors' Choice: Stern P. 2020. Getting a GRIP on AMPARs. Science 370 (6513): 183-184

3

Mejias R, Chiu S-L, Han M, Rose R, Gil-Infante A, Zhao Y, Huganir RL, Wang T. 2019 Purkinje cell-specific Grip1/2 knockout mice show increased repetitive self-grooming and enhanced mGluR5 signaling in cerebellum. Neurobiology of Disease, 132:104602.

4

Wang Q, Chiu S-L*, Koropouli E*, Hong I*, Mitchell S, Easwaran TP, Hamilton N, Gustina A, Zhu Q, Ginty DD, Huganir RL, Kolodkin AL. 2017 Neuropilin-2/PlexinA3 receptors associate with GluA1 and mediate Sema3F-dependent homeostatic scaling in cortical neurons. Neuron 96(5): 1084-1098 (*: Equal contribution) Faculty Recommendation: Hell J. University of California, Davis. 2017 Faculty Opinions

Faculty Recommendation: Hell J. University of California, Davis. 2017 Faculty Opinions

5

Chiu S-L, Diering G, Ye B, Takamiya K, Jiang Y, Niranjan T, Schwartz CE, Wang T and Huganir RL. 2017 GRASP1 regulates synaptic plasticity and memory through endosomal recycling of AMPA receptors. Neuron 93(6): 1405-1419

Editors' Choice: Ferrarelli L. K. 2017. Sorting out memory and learning. Science Signaling 10 (477): eaan5454

6
Chen C-M, Orefice L*, Chiu S-L*, LeGates T, Hattar S, Huganir RL, Zhao H, Xu B and Kuruvilla R. 2017 Wnt5a is essential for hippocampal dendritic maintenance and spatial learning and memory in adult mice. Proc Natl Acad Sci USA 114(4): E619-28 (*: Equal contribution)
7
Gu Y, Chiu S-L, Liu B, Wu PH, Delannoy M, Lin DT, Wirtz D and Huganir RL. 2016 Differential vesicular sorting of AMPA and GABAA receptors. Proc Natl Acad Sci USA 113 (7): E922-31
8
Volk L, Chiu S-L, Sharma K, Huganir RL. 2015 Glutamate synapses in human cognitive disorders. Annual Review of Neuroscience 38(1): 127-49
9

Thomas GM, Hayashi T, Chiu S-L, Chen CM and Huganir RL. 2012 Palmitoylation by DHHC5/8 targets GRIP to dendritic endosomes to regulate AMPA-R trafficking. Neuron 73(3): 482-96

10
Chiu S-L and Cline HT. 2010. Insulin receptor signaling in the development of neuronal structure and function. Neural Development 5(7)