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研究人員｜中央研究院 細胞與個體生物學研究所

研究人員
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側邊選單開關 研究人員
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  • 哈圖林Konstantin Khalturin
    副研究員Associate Research Fellow
    • 專長：Comparative genomics, Developmental biology, Stem cells in basal metazoa, Transgenic Hydra
    • 信箱： khalturin@gate.sinica.edu.tw
    • 電話：02-2789-9565
    • 網站： 哈圖林老師實驗室
    • 位置：R426 /ICOB, MRS
友善列印
經歷簡介展開收合
2022-
Associate Research Fellow, Institute of Cellular and Organismic Biology, Academia Sinica, Taiwan
2013 - 2022
Staff Scientist, Okinawa Institute of Science and Technology Graduate University, Marine Genomics Unit (Prof. Satoh), Okinawa, Japan
2010-2011
Acting Full Professor for Zoology (W3), Zoological Institute of Christian-Albrechts University, Kiel, Germany
2009-
Senior lecturer (Privatdozent), Zoological Institute of Christian-Albrechts University, Kiel, Germany
2009
Habilitation in Zoology and Cell Biology, CAU, Kiel, Germany
2003-2008
Assistant Professor (Wissenschaftlicher Assistent, C1), Zoological Institute of Christian-Albrechts University, Kiel, Germany
2000-2002
Ph.D student at Zoological Institute, Christian-Albrechts University of Kiel, Germany. Dr.rer.nat. degree in Biology („summa cum laude“)
1997-1999
Department of Invertebrate Zoology, St.Petersburg State University, Russia. M.Sc. degree in Biology.
1993-1997
Biological Faculty, St.Petersburg State University, Russia. B.Sc. degree in Biology
研究方向展開收合

(a) Evolution of complex life cycles.
How genomic information regulates the development of planula, polyp and jellyfish stages and what was the ancestral cnidarian body plan?

(b) Molecular basis of evolutionary novelties.
How novel body plans, structures, cell types and genes emerge? What is the function of "novel" genes?

(c) Stem cell systems in cnidarians.
What are the similarities and differences in the organization of stem cell systems in Cnidaria? What is the molecular basis of unlimited life span in Hydra and scyphozoan polyps?

(d) Development of transgenic technology for cnidarian models.
Better understanding of pattern formation and cellular fates by using fluorescent markers.

代表著作展開收合
  1. Khalturin K., Shunatova N., Shchenkov S., Sasakura Y, Kawamitsu M., Satoh N. (2022) Polyzoa is back: the effect of complete gene sets on the placement of Ectoprocta and Entoprocta. Science Advances, 8(26). doi: 10.1126/sciadv.abo4400
  2. Shinzato C, Khalturin K, Inoue J, Zayasu Y, Kanda M, Kawamitsu M, Yoshioka Y, Yamashita H, Suzuki G, Satoh N. (2021) Eighteen Coral Genomes Reveal the Evolutionary Origin of Acropora Strategies to Accommodate Environmental Changes. Mol Biol Evol.; 38(1):16-30. doi: 10.1093/molbev/msaa216.
  3. Hamada M, Satoh N, Khalturin K. (2020) A Reference Genome from the Symbiotic Hydrozoan, Hydra viridissima. G3 (Bethesda).;10(11):3883-3895. doi: 10.1534/g3.120.401411.
  4. Khalturin K, Shinzato C, Khalturina M, Hamada M, Fujie M, Koyanagi R, Kanda M, Goto H, Anton-Erxleben F, Toyokawa M, Toshino S, Satoh N. (2019) Medusozoan genomes inform the evolution of the jellyfish body plan. Nat Ecol Evol. 3(5):811-822. doi: 10.1038/s41559-019-0853-y.
  5. Fuchs B, Wang W, Graspeuntner S, Li Y, Insua S, Herbst EM, Dirksen P, Böhm AM, Hemmrich G, Sommer F, Domazet-Lošo T, Klostermeier UC, Anton-Erxleben F, Rosenstiel P, Bosch TC, Khalturin K. (2014) Regulation of polyp-to-jellyfish transition in Aurelia aurita. Curr Biol. 24(3):263-73.
  6. Boehm AM*, Khalturin K*, Anton-Erxleben F, Hemmrich G, Klostermeier UC, Lopez-Quintero JA, Oberg HH, Puchert M, Rosenstiel P, Wittlieb J, Bosch TC. (2012) FoxO is a critical regulator of stem cell maintenance in immortal Hydra. Proc Natl Acad Sci USA. 109(48):19697-702. (* - equally contributed to the paper)
  7. Hemmrich G, Khalturin K, Boehm AM, Puchert M, Anton-Erxleben F, Wittlieb J, Klostermeier UC, Rosenstiel P, Oberg HH, Domazet-Loso T, Sugimoto T, Niwa H, Bosch TC. (2012) Molecular signatures of the three stem cell lineages in Hydra and the emergence of stem cell function at the base of multicellularity. Mol Biol Evol. 29(11):3267-80.
  8. Khalturin K, Hemmrich G, Fraune S, Augustin R, Bosch TC. (2009) More than just orphans: are taxonomically-restricted genes important in evolution? Trends Genet. 25(9):404-13.
  9. Khalturin K, Anton-Erxleben F, Sassmann S, Wittlieb J, Hemmrich G, Bosch TC. (2008) A novel gene family controls species-specific morphological traits in Hydra. PLoS Biology, 6(11):e278
  10. Wittlieb J, Khalturin K, Lohmann JU, Anton-Erxleben F, Bosch TC. (2006) Transgenic Hydra allow in vivo tracking of individual stem cells during morphogenesis. Proc Natl Acad Sci USA., 103(16):6208-11.