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研究人員|中央研究院 細胞與個體生物學研究所

研究人員
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側邊選單開關 研究人員
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  • 游智凱Jr-Kai Yu
    副研究員兼臨海研究站主任Associate Research Fellow & MRS Chief
    • 專長:Developmental Biology, Evolution of Development
    • 信箱:jkyu@gate.sinica.edu.tw
    • 電話:02-2787-1516, 03-9880544 ext 17
    • 網站: 游智凱老師實驗室
    • 位置:R403/ICOB
經歷簡介展開收合
2016
Associate Research Fellow, Institute of Cellular and Organismic Biology, Academia Sinica
2007-2016
Assistant Research Fellow, Institute of Cellular and Organismic Biology, Academia Sinica
2005-2007
Postdoctoral Scholar, Division of Biology, California Institute of Technology, USA.
2005
Postdoctoral research fellow, Marine Biology Research Division, Scripps Institution of Oceanography, University of California, San Diego, USA.
2005
Ph.D., Marine Biology Research Division, Scripps Institution of Oceanography, University of California, San Diego, USA
研究方向展開收合

我的研究興趣在於瞭解發育機制的演化,主要以頭索動物文昌魚作為研究模式生物。文昌魚屬於脊索動物中的一個亞門,雖然它是無脊椎動物,但一般利用它作為一種模式生物來探討脊椎動物祖先可能具有的特徵。文昌魚與脊椎動物都具備脊索動物的基本特徵,例如:背神經管、脊索、肌節、以及鰓裂。然而脊椎動物進一步演化出文昌魚所沒有的特徵,包括:特化的頭部結構與前腦、具有遷移性的神經脊細胞群和經由外胚層增厚所產生的周圍感覺神經組織,以及高度礦化的內骨骼系統。我希望經由對文昌魚胚胎發育機制的研究來了解脊索動物發育的共同基礎機制;同時由於文昌魚在類緣關係上的特殊地位,文昌魚與脊椎動物的比較研究將可以提供重要的資訊來讓我們瞭解脊椎動物體制特徵發育的起源。我們的研究團隊在近年也結合次世代與第三世代長序列定序平台資料,進行跨物種比較基因體與轉錄體研究,分析不同後口類動物門的基因體結構與發育轉錄體的保守性程度以及可能的分歧點,來幫助我們暸解有關後口類動物門間的演化過程與脊索動物以及脊椎動物的起源。

代表著作展開收合
  1. Yong LW, Lu TM, Tung CH, Chiou RJ, Li KL, & Yu JK* (2021) Somite compartments in amphioxus and its implications on the evolution of the vertebrate skeletal tissues. Front Cell Dev Biol 9:607057.
  2. Lin CY, Yu JK*, & Su YH* (2021) Evidence for BMP-mediated specification of primordial germ cells in an indirect-developing hemichordate. Evol & Dev 2021 23:28-45.
  3. Lin CY, Lu MYJ, Yue JX, Li KL. Le Pétillon Y, Yong LW, Chen YH, Tsai FU, Lyu YF, Chen CY, Hwang SPL, Su YH*, & Yu JK* (2020) Molecular asymmetry in the cephalochordate embryo revealed by single-blastomere transcriptome profiling. PLOS Genetics 16:e1009294.
  4. Simakov O*, Marletaz F, Yue JX, O'Connell B, Jenkins J, Brandt A, Calef R, Tung CH, Huang TK, Schmutz J, Satoh N, Yu JK, Putnam NH, Green RE, & Rokhsar DS* (2020). Deeply conserved synteny resolves early events in vertebrate evolution. Nat Ecol Evol 4:820-830. 
  5. Su YH*, Chen YC, Ting HC, Fan TP, Lin CY, Wang KT, & Yu JK* (2019). BMP controls dorsoventral and neural patterning in indirect-developing hemichordates providing insight into a possible origin of chordates. Proc Natl Acad Sci USA 116:12925-12932. 
  6. Kawaguchi M, Sugiyama K, Matsubara K, Lin CY, Kuraku S, Hashimoto S, Suwa Y, Yong LW, Takino K, Higashida S, Kawamura D, Yu JK & Seki Y*(2019) Co-option of the PRDM14–CBFA2T complex from motor neurons to pluripotent cells during vertebrate evolution. Development 146: dev168633.
  7. Marletaz F, Firbas PN, Maeso I*, Tena JJ, Bogdanovic O, Perry M, Wyatt CDR, de la Calle-Mustienes E, Bertrand S, Burguera D, Acemel RD, van Heeringen SJ, Naranjo S, Herrera-Ubeda C, Skvortsova K, Jimenez-Gancedo S, Aldea D, Marquez Y, Buono L, Kozmikova I, Permanyer J, Louis A, Albuixech-Crespo B, Le Petillon Y, Leon A, Subirana L, Balwierz PJ, Duckett PE, Farahani E, Aury JM, Mangenot S, Wincker P, Albalat R, Benito-Gutierrez E, Canestro C, Castro F, D'Aniello S, Ferrier DEK, Huang S, Laudet V, Marais GAB, Pontarotti P, Schubert M, Seitz H, Somorjai I, Takahashi T, Mirabeau O, Xu A, Yu JK, Carninci P, Martinez-Morales JR, Crollius HR, Kozmik Z, Weirauch MT, Garcia-Fernandez J, Lister R, Lenhard B, Holland PWH, Escriva H*, Gomez-Skarmeta JL*, & Irimia M* (2018) Amphioxus functional genomics and the origins of vertebrate gene regulation. Nature. 564:64-70. 
  8. Nakashima K*, Kimura S, Ogawa Y, Watanabe S, Soma S, Kaneko T, Yamada L, Sawada H, Tung CH, Lu TM, Yu JK, Villar-Briones A, Kikuchi S, & Satoh N (2018) Chitin-based barrier immunity and its loss predated mucus-colonization by indigenous gut microbiota. Nat Commun 9(1):3402.
  9. Hu H, Uesaka M, Guo S, Shimai K, Lu TM, Li F, Fujimoto S, Ishikawa M, Liu S, Sasagawa Y, Zhang G, Kuratani S, Yu JK, Kusakabe TG, Khaitovich P, Irie N*, and the EXPANDE Consortium (2017) Constrained vertebrate evolution by pleiotropic genes. Nat Ecol Evol 1:1722-1730.
  10. Yong LW, & Yu JK* (2016) Tracing the evolutionary origin of vertebrate skeletal tissues: insights from cephalochordate amphioxus. Curr Opin Genet Dev, 39:55-62