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側邊選單開關 研究人員
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友善列印
經歷簡介展開收合
2015-present
Research Fellow, Marine Research Station, Institute of Cellular and Organismic Biology, Academia Sinica, Taiwan
2011-2015
Associate Research Fellow, Marine Research Station, Institute of Cellular and Organismic Biology, Academia Sinica, Taiwan
2007- 2011
Assistant Research Fellow, Marine Research Station, Institute of Cellular and Organismic Biology, Academia Sinica, Taiwan
2003- 2007
Assistant Research Scientist, Marine Research Station, Institute of Cellular and Organismic Biology, Academia Sinica, Taiwan
2001- 2002
Postdoctoral Research Associate, The Sanger Institute Wellcome Trust, Cambridge U.K.
2000- 2001
Postdoctoral Research Fellow, Institute of Zoology, Academia Sinica, Taiwan
1997
Ph.D. Institute of Zoology, National Taiwan University, Taiwan
研究方向展開收合

The Antimicrobial Peptide Research Laboratory is an integral part of the Marine Research Station, Institute of Cellular and Organismic Biology (ICOB), Academia Sinica. It is situated in the vibrant Marine Research Station campus at 23-10 Dawen Rd., Jiaushi, Ilan 262, Taiwan, and headed by Prof. Jyh-Yih Chen, Research Fellow, Academia Sinica (http://140.109.49.7/~mrs/facaulty_JYC.html). The primary focus of the laboratory is to explore how peptides from marine sources may be developed into therapeutically active drugs. Peptides are responsible for diverse physiological functions, and the actions of antimicrobial peptides are highly significant for the survival of nearly all species. Over the past several years, our work exploring the potential clinical applications of piscidin and epinecidin-1 has led them to become prominent antimicrobial peptides. We also seek to design and explore how to best modify antimicrobial peptides from marine organisms in order to decrease the peptide toxicity and increase the half-life in serum. In one project, the novel anticancer peptides we have derived from antimicrobial peptides are conjugated to homing peptides in an effort to develop cancer therapeutics with high specificity and low side effects. The dedication of the researchers in the laboratory is evident from their high-impact publications, patents, and products. Most importantly, the laboratory provides a home to nurture budding scientists. Master's degree students, Research Assistants, Ph.D. students, and experienced Postdoctoral Scientists from national and international locations work together and contribute to the growth of the laboratory. The ethical and scientific standards of the laboratory are of international repute, as scientific merit is the primary focus of our work. Equal opportunity is provided to every individual irrespective of gender, nationality, caste, or other status. The laboratory welcomes all budding researchers with innovative ideas, as we believe that innovation is key to future advancements and beneficial outcomes for society.

“An experiment is a question which science poses to Nature, and a measurement is the recording of Nature’s answer.” ― Max Planck

代表著作展開收合
  1. Bor-Chyuan Su, Chieh-Yu Pan, Jyh-Yih Chen* (2019). Antimicrobial peptide TP4 induces ROS-mediated necrosis by triggering mitochondrial dysfunction in wild-type and mutant p53 glioblastoma cells. Cancers (Basel). Cancers (Basel). 2019 Feb 1;11(2). pii: E171. doi: 10.3390/cancers11020171. *Corresponding author. 
  2. Bor-Chyuan Su, Han-Ning Huang, Tai-Wen Lin, Chwan-Deng Hsiao, Jyh-Yih Chen* (2017). Epinecidin-1 protects mice from LPS-induced endotoxemia and cecal ligation and puncture-induced polymicrobial sepsis. BBA - Molecular Basis of Disease (in press) *Corresponding author.
  3. Jayaram Lakshmaiah Narayana, Han-Ning Huang, Chang-Jer Wu*, Jyh-Yih Chen* (2015). Epinecidin-1 Bactericidal Activity: Membrane Destabilization via Saddle-Splay Curvature Generation, and Modulation of Helicobacter pylori-Induced Host Immune Responses in a Mouse Model. Biomaterials 61:41-51. *Corresponding author. 
  4. Wu-Fu Chen, Shi-Ying Huang, Chang-Yi Liao, Chun-Sung Sung, Jyh-Yih Chen*, Zhi-Hong Wen* (2015). The use of the antimicrobial peptide piscidin (PCD)-1 as a novel anti-nociceptive agent. Biomaterials 53:1-11. *Corresponding author. 
  5. Chen-Hung Ting, Han-Ning Huang, Tsui-Chin Huang, Chang-Jer Wu, Jyh-Yih Chen* (2014). The mechanisms by which pardaxin, a natural cationic antimicrobial peptide, targets the endoplasmic reticulum and induces c-FOS. Biomaterials 35(11):3627-3640. *Corresponding author. 
  6. Han-Ning Huang, Venugopal Rajanbabu, Chieh-Yu Pan, Yi-Lin Chan, Chang-Jer Wu*, Jyh-Yih Chen* (2013). Use of the antimicrobial peptide Epinecidin-1 to protect against MRSA infection in mice with skin injuries. Biomaterials 34(38):10319-10327. *Corresponding author. 
  7. Han-Ning Huang, Venugopal Rajanbabu, Chieh-Yu Pan, Yi-Lin Chan, Chang-Jer Wu*, Jyh-Yih Chen* (2013). A cancer vaccine based on the marine antimicrobial peptide pardaxin (GE33) for control of bladder-associated tumors. Biomaterials 34(38):10151-10159. *Corresponding author. 
  8. Han-Ning Huang, Venugopal Rajanbabu, Chieh-Yu Pan , Yi-Lin Chan, Cho-Fat Hui, Jyh-Yih Chen*, Chang-Jer Wu* (2011). Modulation of the immune-related gene responses to protect mice against Japanese encephalitis virus using the antimicrobial peptide, tilapia hepcidin 1-5. Biomaterials 32(28):6804-14. *Corresponding author. 
  9. Han-Ning Huang, Chieh-Yu Pan, Venugopal Rajanbabu, Chang-Jer Wu*, Jyh-Yih Chen* (2011). Modulation of immune responses by the antimicrobial peptide, epinecidin (Epi)-1, and establishment of an Epi-1 based inactivated vaccines. Biomaterials 32(14):3627-3636. *Corresponding author. 
  10. Venugopal Rajanbabu, Jyh-Yih Chen* (2011). Applications of antimicrobial peptides from fish and perspectives for the future. Peptides 32(2):415-420. *Corresponding author.