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研究人員|中央研究院 細胞與個體生物學研究所

研究人員
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側邊選單開關 研究人員
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  • 許惠真Hwei-Jan Hsu
    副研究員兼副所長Associate Research Fellow & Deputy Director
    • 專長:Developmental Biology, Stem cell Biology
    • 信箱:cohsu@gate.sinica.edu.tw
    • 電話:02-2787-1541
    • 網站: 幹細胞研究實驗室
    • 位置:R337/ICOB
經歷簡介展開收合
2017-
Associate Research Fellow, Institute of Cellular and Organismic Biology, Academia Sinica, Taiwan
2010-2017
Assistant Research Fellow, Institute of Cellular and Organismic Biology, Academia Sinica, Taiwan
2009-2010
Postdoctoral Research Fellow, Institute of Molecular Biology and Biochemistry, Johns Hopkins School of Public Health, USA
2006-2009
Postdoctoral Research Fellow, Department of Cell and Developmental Biology, Vanderbilt University Medical Center, USA
2005
Ph.D. Institute of Life Science, National Defense Medical Center, Taiwan
研究方向展開收合

我們實驗室主要是利用果蠅卵巢的生殖幹細胞和腸道幹細胞來研究幹細胞在受到外在環境的刺激時如何因應以維持組織的恆定。成體幹細胞對於組織恆定的維持十分重要。這是因為成體幹細胞以不對稱分裂的方式產生二個子細胞, 其中一個子細胞會取代原有的幹細胞,而另一個子細胞則會分裂及分化以補充組織所耗損的細胞。幹細胞的活性減低會造成組織衰退,而幹細胞的活性被不正常的活化時則會轉變成癌幹細胞進而導致腫瘤的生成。因此幹細胞的活性必須受到嚴格的調控。成體幹細胞位在一個特異化的微小環境,稱之為幹細胞 niche。Niche 細胞會釋放不同的蛋白訊息來調控幹細胞,例如BMP 訊息對於許多幹細胞的維持都十分重要。除此之外,在老化或外界環境的刺激之下 (如飲食) 生物體也能自行協調幹細胞的活動以維持體內各個組織的恆定。然而到目前為止對於niche怎麼形成以及外界刺激如何影響幹細胞的分子機制仍舊不清楚。

我們利用果蠅卵巢生殖幹細胞和腸道幹細胞來研究: 1. 幹細胞niche是如何建立的?2. 幹細胞如何被維持在niche中?3. 幹細胞如何應飲食和老化?

代表著作展開收合
  1. Amartuvshin, O., Lin, C-H., Hsu, S-C., Kao, S-H., Chen, A., Tang, W-C., Chou, H-L., Chang, D-L., Hsu, Y-Y., Hsiao, B-S., Rastegari, E., Lin, K-Y., Wang, Y-T., Yao, C-K., Chen, G-C., Chen, B-C., and Hsu, H-J*. (2020) Aging shifts mitochondrial dynamics toward fission to promote germline stem cell loss. Aging Cell.
  2. Lin, K-Y., Wang, W-D., Lin, C-H., Rastegari, E., Su, Y-H., Chang, Y-C., Chang, Y-T., Liao, Y-F., Pi, HW., Yu, B-Y., Chen, S-H., Lin, C-Y., Lu, M-Y., Su, T-Y., Tzou, F-Y., Chan, C-C., and Hsu, H-J*. (2020) Piwi Reduction in the Aged Niche Eliminates Germline Stem Cells via Toll-GSK3 Signaling. Nature Communications, 11, article number: 3147. 
  3. Rastegari E, Kajal K, Tan B-S, Huang F, Chen R-H, Hsieh T-S, and Hsu H-J*, 2020, “WD40 protein Wuho controls germline homeostasis via TRIM-NHL tumor suppressor Mei-p26 in Drosophila”, Development, 147(2). pii: dev182063. . 
  4. Ke Y-T and Hsu H-J*, 2019, “Generation of Inducible Gene-Switched GAL4 Expressed in the Drosophila Female Germline Stem Cell Niche.”, G3-Genes Genomes Genetics, 9(6), 2007-2016. 
  5. Su Y-H, Rastegri E, Kao S-H, Lai C-M, Lin K-Y, Liao H-Y Wang M-H and Hsu H-J*, 2018, “Diet Regulates Membrane Extension and Survival of Niche Escort Cells for Germline Homeostasis via Insulin signaling”, Development, 145(7), dev159186. 
  6. Tseng C-Y, Su Y-H, Yang S-M, Lin K-Y, Lai C-M, Rastegari E, Amartuvshin O, Cho Y, Cai Y, Hsu H-J*, 2018, “Smad-Independent BMP Signaling in Somatic Cells Limits the Size of the Germline Stem Cell Pool.”, Stem cell reports, 11(3), 811-827. 
  7. Lai C-M, Lin K-Y, Kao S-H, Chen Y-N, Huang F, Hsu H-J*, 2017, “Hedgehog signaling establishes precursors for germline stem cell niches by regulating cell adhesion”, The Journal of Cell Biology, 216(5), 1439-1453. 
  8. Tseng, C-Y., Kao, S-H., Wan, C-L., Cho, Y., Tung, S-Y., and Hsu, H-J*. (2014) Notch signaling mediates the age-associated decrease in adhesion of germline stem cells to the niche. PLOS Genetics,10(12):e1004888. doi: 10.1371
  9. Kao, S-H., Tseng, C-Y., Wan, C-L., Su, Y-H., Hsieh, C-C., Pi, H., and Hsu, H-J*. (2015) Aging and insulin signaling differentially control normal and tumorous germline stem cells. Aging Cell,14(1): 25-34.
  10. Yang, S-A., Wang, W-D., Chen, C-T., Tseng, C-Y., Chen, Y-N., and Hsu, H-J*. (2013). FOXO/Fringe is necessary for maintenance of the germline stem cell niche in response to insulin insufficiency. Developmental Biology 382, 124-135.