Go to the content anchor

Wan-Chen Huang｜ logologo Institute of Cellular and Organismic Biology, Academia Sinica

Faculty
:::
aside menu open Faculty
:::

Article content area

  • Profile photo of Wan-Chen Huang
    Wan-Chen Huang Professor Wan-Chen Huang Research ID Professor Wan-Chen Huang ORCID
    Associate Research Scientist
    • SpecialtySingle-molecule biophysics, Neuropharmacology, Signal transduction
    • E-mailwchuang1@gate.sinica.edu.tw
    • Tel02-2787-1536
    • Website Single-Molecule Biology Core Lab
    • LabR526/ICOB
Print
Professional ExperienceOpenClose
2023-present
Associate Research Scientist, Institute of Cellular and Organismic Biology, Academia Sinica, Taiwan
2018-
Adjunct Assistant Professor, Institute of Medical Device and Imaging, National Taiwan University, Taiwan
2017-2023
Assistant Research Scientist, Institute of Cellular and Organismic Biology, Academia Sinica, Taiwan
2010-2017
Academia Sinica Postdoctoral Fellow, Taiwan
2009-2010
Postdoctoral Fellow, Graduate Institute of Pharmacology, National Cheng-Kung University College of Medicine, Taiwan
2004-2009
Ph.D. Physiology, Anatomy and Genetics, University of Oxford, UK
Selected PublicationOpenClose
  1. Hsieh SE, Lai JZ, Lai KY, Huang WC, Chien FC*. Quantum Well-Enhanced Plasmonic Substrate to Enhance Spontaneously Blinking Fluorescence for Single-Molecule Localization Microscopy. Anal Chem. 2026 Mar 24;98(11):7999-8009. PMID: 41805316. 
  2. Ho CY, Chang YJ, Yang CW, Shih O, Jeng US, Hwang IS, Huang WC, Chen YR*. Membrane Disruption Properties of Poly-Glycine Arginine Dipeptide Repeats Affected by Peptide Repeats Continuity and Membrane Composition. J Mol Biol. 2025 Sep 1;437(17):169296. PMID: 40513650. 
  3. Chen YC, Lee KY, Liao HJ, Sun WL, Huang WC, Wang YS, Chang WC, Liu CH*. A tumor on a chip for studying immune-cell infiltration into tumor under chemo/immunotherapy treatments. Sensors and Actuators B: Chemical. 2024 May 1; 406: 135409. doi:10.1016/j.snb.2024.135409. 
  4. Lee CC, Yu CJ, Panda SS, Chen KC, Liang KH, Huang WC, Wang YS, Ho PC, Wu HC*. Epithelial cell adhesion molecule (EpCAM) regulates HGFR signaling to promote colon cancer progression and metastasis. J Transl Med. 2023 Aug 5;21(1):530. PMID: 37543570. 
  5. Wang YS, Yeh TK, Chang WC, Liou JP, Liu YM*, Huang WC*. 2,6-Difluorobenzamide derivatives as store-operated calcium channel (SOC) inhibitors. Eur J Med Chem. 2022 Dec 5;243:114773. PMID: 36179401.  
  6. Wang YS, Huang NK, Lin YC, Chang WC*, Huang WC*. Aspirin and Sulindac act via different mechanisms to inhibit store-operated calcium channel: Implications for colorectal cancer metastasis. Biomed Pharmacother. 2022 Jan;145:112476. PMID: 34864310. 
  7. Huang WC*, Lee CY, Hsieh TS. Single-molecule Förster resonance energy transfer (FRET) analysis discloses the dynamics of the DNA-topoisomerase II (Top2) interaction in the presence of TOP2-targeting agents. J Biol Chem. 2017 Jul 28;292(30):12589-12598. PMID: 28630044. 
  8. Wong HS, Chang CM, Liu X, Huang WC*, Chang WC*. Characterization of cytokinome landscape for clinical responses in human cancers. Oncoimmunology. 2016 Nov 4;5(11):e1214789. PMID: 27999736. 
  9. Huang WC, Chen ST, Chang WC, Chang KY, Chang WC, Chen BK*. Involvement of aryl hydrocarbon receptor nuclear translocator in EGF-induced c-Jun/Sp1-mediated gene expression. Cell Mol Life Sci. 2010 Oct;67(20):3523-33. PMID: 20508969. 
  10. Huang WC, Swietach P, Vaughan-Jones RD, Ansorge O, Glitsch MD*. Extracellular acidification elicits spatially and temporally distinct Ca2+ signals. Curr Biol. 2008 May 20;18(10):781-785. PMID: 18485712.