Go to the content anchor

Hung-Hsiang Yu|Institute of Cellular and Organismic Biology, Academia Sinica

aside menu open Faculty

Article content area

  • Hung-Hsiang Yu
    Associate Research Fellow
Professional ExperienceOpenClose
Associate Research Fellow, Institute of Cellular and Organismic Biology, Academia Sinica, Taiwan.
Assistant Research Fellow, Institute of Cellular and Organismic Biology, Academia Sinica, Taiwan.
Research Specialist, Janelia Farm Research Campus, Howard Hughes Medical Institute, USA.
Postdoctoral Fellow, Department of Neurobiology, University of Massachusetts Medical School, USA.
Postdoctoral Fellow, Division of Basic Sciences, Fred Hutchinson Cancer Research Center, USA.
Ph.D., Department of Neuroscience, Johns Hopkins University School of Medicine, USA.
Research InterestOpenClose

Insect and mammalian olfactory systems share similar glomerular organizations and remarkable information processing ability to discriminate thousands of odors in the environment, which is crucial for animals to look for food, avoid predators and seek for mates. We utilize Drosophila as a model to investigate how the olfactory system is assembled during development. Olfactory sensory neurons (OSNs) expressing the same olfactory receptor project axons into one of 50 morphologically-identifiable glomeruli in the primary olfactory center of the brain, the antennal lobe (AL), where dendrites of distinct types of projection neurons (PN) synapse with corresponding OSN axons to relay odorant information to high-order olfactory centers, including the mushroom body (MB) and lateral horn (LH), for further odorant decoding (Figure 1). An accurate olfactory connectivity map endows the olfactory system with the sensitive, robust and accurate odor-processing ability, and generating such a map relies on precise interconnections between appropriate OSN axons and PN dendrites within AL glomeruli. Our first research goal is to determine cellular and molecular mechanisms underlying how Semaphorin-1a (Sema-1a), a transmembrane protein crucial for neurite guidance, regulates the generation of proper PN dendritic patterns (Figure 2). Besides the robust and reliable response to external stimuli, the olfactory system also needs to adjust its wiring capacity to adapt into a changing environment. MB neurons are ideal model neurons to study the dynamic process of olfactory system formation, particularly on (i) how MB neurons are specified into same and different types of neurons in the system; (ii) how MB neurons undergo remodeling to trim existing connections and re-establish new connections. Our second research goal is to determine how MB neuron development impacts the olfactory system formation (Figure 3).

Selected PublicationOpenClose
  1. Lai, Y.W., Miyares, R.L., Liu, L.Y., Chu, S.Y., Lee, T. and Yu, H.H. (2022). Hormone-controlled changes in the differentiation state of post-mitotic neurons. Current Biology 32, 1-8. doi: 10.1016/j.cub.2022.04.027.
  2. Wei, J.Y., Chu, S.Y., Hung, Y.C., Chung, P.C. and Yu, H.H. (2022). Drosophila septin interacting protein 1 regulates neurogenesis in the early developing larval brain. Scientific Reports, 12 (1): 292. doi: 10.1038/s41598-021-04474-3.
  3. Lin, T.Y., Chen, J.P., Yu, H.H., Hsu C.P. and Lee, C.H. (2021). Extrinsic factors regulating dendritic patterning. Front. Cell. Neuroscience, 14, 622808. doi: 10.3389/fncel.2020.622808
  4. Garcia-Marques, J., Espinosa-Medina, I., Ku, K.Y., Yang, C.P., Koyama, M., Yu, H.H. and Lee, T. (2020).  A programmable sequence of reporters for lineage analysis. Nature Neuroscience, 23: 1618-1628. doi: 10.1038/s41593-020-0676-9.
  5. Lai, Y.W., Chu, S.Y., Li, J.C., Chen, P.L., Chen, C.H. and Yu, H.H. (2020).  Visualization of Endogenous Type I TGF-β Receptor Baboon in the Drosophila Brain. Scientific Reports 10 (1): 5153. doi: 10.1038/s41598-020-61950-y.
  6. Hsu, T.C., Ku, K.Y., Shen, H.C. and Yu, H.H. (2020). Overview of MARCM-related technologies in Drosophila neurobiological research. Current Protocols in Neuroscience, 91, e90. doi: 10.1002/cpns.90.
  7. Wei, J.Y., Chung, P.C., Chu, S.Y., and Yu, H.H. (2019). FOXO Regulates Cell Fate Specification of Drosophila Ventral Olfactory Projection Neurons. Journal of Neurogenetics, 33(1): 33-40.  doi: 10.1080/01677063.2018.1556651.
  8. Shen, H.C., Chu, S.Y., Hsu, T.C., Wang, C.H., Lin, I.Y. and Yu, H.H. (2017). Semaphorin-1a Prevents Drosophila Olfactory Projection Neuron Dendrites from Mis-targeting into Select Antennal Lobe Regions. PLOS Genetics 13(4): e1006751. doi: 10.1371/journal.pgen.1006751. 
  9. Lai, Y.W., Chu, S.Y., Wei, J.Y., Cheng, C.Y., Li, J.C., Chen, P.L., Chen, C.H. and Yu, H.H. (2016). Drosophila microRNA-34 Impairs Axon Pruning of Mushroom Body γ Neurons by Downregulating the Expression of Ecdysone Receptor. Scientific Reports 6: 39141. doi: 10.1038/srep39141.
  10. Shen, H.C., Wei, J.Y., Chu, S.Y., Chung, P.C., Hsu, T.C. and Yu, H.H. (2016). Morphogenetic Studies of the Drosophila DA1 Ventral Olfactory Projection Neuron. PLOS One 11 (5): e0155384. doi: 10.1371/journal.pone.0155384.