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New Diagnostic and Therapeutic Strategy for Osteoarthritis: Using “Collagen-Binding Peptides” to Facilitate Imaging, Lubrication, and Regeneration of Articular Cartilage｜Institute of Cellular and Organismic Biology, Academia Sinica

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New Diagnostic and Therapeutic Strategy for Osteoarthritis: Using “Collagen-Binding Peptides” to Facilitate Imaging, Lubrication, and Regeneration of Articular Cartilage

  • Author：Chin-Yu Lin, Yung-Li Wang, Yu-Jen Chen, Chun-Te Ho, Yi-Hsuan Chi, Long Yi Chan, Guan-Wen Chen, Horng-Chaung Hsu, Dennis W. Hwang, Han-Chung Wu & Shih-Chieh Hung
  • Journal： Nature Biomedical Engineering 6, 1105–1117 (2022) https://www.nature.com/articles/s41551-022-00948-5
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Regenerative medicine strategy based on multiple intra-articular injections of bifunctional peptide-guided human mesenchymal stromal cells to osteoartRegenerative medicine strategy based on multiple intra-articular injections of bifunctional peptide-guided human mesenchymal stromal cells to osteoart

The research teams of Dr. Shih-Chieh Hung, China Medical University, and Dr. Han-Chung Wu, Academia Sinica, collaborated to discover new strategies of diagnosis and therapy for osteoarthritis. They successfully developed osteoarthritic collagen-binding peptides and a bifunctional peptide, which have good potential in regenerative medicines for early diagnosis, therapy, and regeneration for osteoarthritis. These peptides can also be used to facilitate regeneration of injured corneal epithelium and endothelium, potentially obviating the need for corneal transplantation.