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研究人員｜中央研究院 細胞與個體生物學研究所

研究人員
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側邊選單開關 研究人員
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  • 黃鵬鵬Pung-Pung Hwang
    客座講座Distinguished Visiting Fellow
    • 專長：Fish Molecular Physiology
    • 信箱：pphwang@gate.sinica.edu.tw
    • 電話：02-2789-9521
    • 網站： 黃鵬鵬老師實驗室
    • 位置：R141/ICOB
友善列印
經歷簡介展開收合
2011-
Jointly-Appointed Professor, Department of Life Science, National Taiwan University
2008-
Distinguished Research Fellow, Institute of Cellular and Organismic Biology, Academia Sinica
1989-2008
Research Fellow, Institute of Zoology/ Cellular and Organismic Biology, Academia Sinica
1989-
Jointly-Appointed Professor, Institute of Fisheries Science, National Taiwan University
1988-1989
Jointly-Appointed Associate Professor, Institute of Fisheries Science, National Taiwan University
1984-1989
Associate Research Fellow, Institute of Zoology, Academia Sinica
1984
Ph.D. in Fisheries Science, University of Tokyo, Japan
1976
B.S. in Zoology, National Taiwan University
研究方向展開收合

魚類滲透壓調節新模式  
滲透壓調節是魚類最基本的生理機制之一。利用斑馬魚、青鱂魚分子操作及生理分析之優勢，我們提出新的魚類滲透壓模式；確認魚鰓及表皮有不同型離子細胞，表現各自特有的運輸蛋白以進行離子收收/排除、酸鹼調節、氨排除等功能。這些新模式較可以更精確、全面的研究魚類如何調體液離子/酸鹼恒定以適應多變的環境。

魚類適應環境變化生理機制
面對水域環境劇變時，魚類即時反應及長期適應決定他們的存活、成長及繁衍。我們利用新模式解明魚類面對環境鹽度或酸度改變時，IGF1和endothelin數分鐘或數小時活化排鹽或排酸機制，數天後則由isotocin和stanniocalcin調節離子細胞增生/分化及運輸蛋白基因表現。我們正持續研究數個荷爾蒙對魚類滲透壓調節的新作用或交互作用。

體內離子/酸鹼恆定機制的演化
經由比較研究數種脊椎動物，我們提出體內離子/酸鹼恆定機制的可能演化過程。八目鰻和少數狹鹽性魚類首次入侵淡水時，可能發展出鰓/表皮排酸機制。大多數廣鹽性及海水魚則以排氨為主要方式；這個排氨機制可能是在淡水魚類逐漸演化，人類腎臟也演化出類似機制。這些發現提供了新的基礎去了解脊椎動物離子調節及環境適應的演化。

代表著作展開收合
  1. Shih, S. W., J. J. Yan, Y. H. Wang, Y. L. Tsou, L. Chiu, Y. C. Tseng, M. Y. Chou and P. P. Hwang (2021) Estrogen-related receptor γ2 controls NaCl uptake to maintain ionic homeostasis. J. Endocrinol. 251:149-159. 
  2. Yan, J. J., Y. C. Lee, Y. L. Tsou, Y. C. Tseng and P. P. Hwang (2020) Insulin-like growth factor 1 triggers salt secretion machinery in fish under acute salinity stress. J. Endocrinol. 246:277-288.
  3. Tong, S. K., H. L. Lee, Y. C. Lee, L. C. Wu, Y. L. Tsou, S. W. Lu, S. W. Shih, P. P. Hwang and M. Y. Chou (2020) Arginine vasopressin modulates ion and acid/base balance by regulating cell numbers of sodium chloride cotransporter and H+-ATPase rich ionocytes. Int. J. Mol. Sci. 21:3957.
  4. Tseng, Y. C., J. J. Yan, F. Furukawa and P. P. Hwang (2020) Did acidic stress resistance in vertebrates evolve as Na+/H+ exchanger-mediated ammonia excretion in fish? Bioessays 42: e1900161
  5. Lin, C. H., H. J. Hu and P. P. Hwang (2017) Molecular physiology of the hypocalcemic action of fibroblast growth factor 23 in zebrafish (Danio rerio). Endocrinol. 158: 1-13.
  6. Takei, Y and P. P. Hwang (2016) Homeostatic Responses to Osmotic Stress. In: Schreck C, Tort L (eds.) Fish Physiology-Biology of Stress in Fish. vol 35., pp 208-251. San Diego: Elsevier Academia Press. 
  7. Wang, Y. F., A. G. Lafont, Y. C. Lee and P. P. Hwang (2016) A novel function of calcitonin gene-related peptide in body fluid Cl- homeostasis. Proc. Biol. Sci. 283: 20160684. 
  8. Guh, Y. J., C. Y. Yang, S. T, Liu, C. J. Huang and P. P. Hwang (2016) Oestrogen-related receptor α is required for transepithelial H+ secretion in zebrafish. Proc. Biol. Sci. 283: 20152582.
  9. Hwang P. P., and L. Y. Lin (2013) Gill ion transport, acid-base regulation and nitrogen excretion. In: Evans D, Claiborne JB and Currie S (eds.) The Physiology of Fishes, 4th Edition. pp 205-233. Boca Raton: CRC Press.
  10. Hwang P. P., T. H. Lee and L. Y. Lin (2011) Ion regulation in fish gills: recent progresses in the cellular and molecular mechanisms. Am. J. Physiol. Comparative/Integrative Physiology. 301: R28-R47. (Invited Review)