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研究人員|中央研究院 細胞與個體生物學研究所

研究人員
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側邊選單開關 研究人員
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  • 丘淑鈴Shu-Ling Chiu
    助研究員Assistant Research Fellow
    • 專長:Synaptic Plasticity, Neural Development, Learning and Memory
    • 信箱:slchiu@gate.sinica.edu.tw
    • 電話:02-2789-9536
    • 網站: 丘淑鈴老師實驗室
    • 位置:R510/ICOB
經歷簡介展開收合
2019
Assistant Research Fellow, Institute of Cellular and Organismic Biology, Academia Sinica, Taiwan
2016-2019
Research Associate, The Johns Hopkins University School of Medicine, Maryland, USA
2008-2016
Postdoctoral Fellow, The Johns Hopkins University School of Medicine, Maryland, USA
2002-2008
Ph.D. program, Watson School of Biological Sciences, Cold Spring Harbor Laboratory, USA
研究方向展開收合

我們目前的研究重點有三:

1.神經傳導受體 (neurotransmitter receptor) 的運輸與功能
在神經細胞的樹突突觸上,神經傳導受體的數目決定了神經傳導的強度與可塑性。自胞內體運輸的分子研究中,我們發現興奮型 AMPA 受體和抑制型GABAA 受體的突觸表達有其特定的調控機制。我們正進一步在了解這些興奮型/抑制型受體的調控在大腦網絡中與動物行為上的影響。

2. 神經突觸連結 (synaptic connectivity) 的發育與維持
突觸連結自發育到成年,是由不斷的突觸形成、消除與維持間的動態平衡來決定的,期對大腦網絡的傳導路徑有著直接的影響。利用雙光子顯微影像技術,我們正在深入了解在正常生理狀況下,神經突觸與神經傳導受體是如何在小鼠腦內維持和調整神經突觸的連結與網絡的功能。

3. 麩胺酸突觸 (glutamatergic synapse) 在神經發育疾病中角色
在神經發育疾病的患者中常見有麩胺酸突觸的結構和功能異常。利用基因編輯技術,我們創造了帶有自病患中發現的基因變異的小鼠模型,以研究這些在麩胺酸突觸相關的基因變異,對智力障礙和自閉症症候群的致病機制與治療開發。

代表著作展開收合
1

Tan HL*, Chiu S-L*, Zhu Q*, and Huganir RL. 2020. GRIP1 regulates synaptic plasticity and learning and memory. Proc Natl Acad Sci USA 117(40): 25085-25091 (*: Equal contribution) Editors' Choice: Stern P. 2020. Getting a GRIP on AMPARs. Science 370 (6513): 183-184

2

Mejias R, Chiu S-L, Han M, Rose R, Gil-Infante A, Zhao Y, Huganir RL, Wang T. 2019 Purkinje cell-specific Grip1/2 knockout mice show increased repetitive self-grooming and enhanced mGluR5 signaling in cerebellum. Neurobiology of Disease, 132:104602.

3

Wang Q, Chiu S-L*, Koropouli E*, Hong I*, Mitchell S, Easwaran TP, Hamilton N, Gustina A, Zhu Q, Ginty DD, Huganir RL, Kolodkin AL. 2017 Neuropilin-2/PlexinA3 receptors associate with GluA1 and mediate Sema3F-dependent homeostatic scaling in cortical neurons. Neuron 96(5): 1084-1098 (*: Equal contribution) Faculty Recommendation: Hell J. University of California, Davis. 2017 Faculty Opinions

Faculty Recommendation: Hell J. University of California, Davis. 2017 Faculty Opinions

4

Chiu S-L, Diering G, Ye B, Takamiya K, Jiang Y, Niranjan T, Schwartz CE, Wang T and Huganir RL. 2017 GRASP1 regulates synaptic plasticity and memory through endosomal recycling of AMPA receptors. Neuron 93(6): 1405-1419

Editors' Choice: Ferrarelli L. K. 2017. Sorting out memory and learning. Science Signaling 10 (477): eaan5454

5
Chen C-M, Orefice L*, Chiu S-L*, LeGates T, Hattar S, Huganir RL, Zhao H, Xu B and Kuruvilla R. 2017 Wnt5a is essential for hippocampal dendritic maintenance and spatial learning and memory in adult mice. Proc Natl Acad Sci USA 114(4): E619-28 (*: Equal contribution)
6
Gu Y, Chiu S-L, Liu B, Wu PH, Delannoy M, Lin DT, Wirtz D and Huganir RL. 2016 Differential vesicular sorting of AMPA and GABAA receptors. Proc Natl Acad Sci USA 113 (7): E922-31
7
Volk L, Chiu S-L, Sharma K, Huganir RL. 2015 Glutamate synapses in human cognitive disorders. Annual Review of Neuroscience 38(1): 127-49
8

Thomas GM, Hayashi T, Chiu S-L, Chen CM and Huganir RL. 2012 Palmitoylation by DHHC5/8 targets GRIP to dendritic endosomes to regulate AMPA-R trafficking. Neuron 73(3): 482-96

9
Chiu S-L and Cline HT. 2010. Insulin receptor signaling in the development of neuronal structure and function. Neural Development 5(7)
10
Chiu S-L, Chen CM, Cline HT. 2008. Insulin receptor signaling regulates synapse number, dendritic plasticity and circuit function in vivo. Neuron 58(5): 708-719