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研究人員｜中央研究院 細胞與個體生物學研究所

研究人員
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側邊選單開關 研究人員
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  • 易玲輝Ling-Huei Yih
    副研究員Associate Research Fellow
    • 專長：Cell Biology, Genetic Toxicology
    • 信箱：lhyih@gate.sinica.edu.tw
    • 電話：02-2789-9510
    • 網站： 易玲輝老師實驗室
    • 位置：R235/ICOB
友善列印
經歷簡介展開收合
2001-2002
Assistant Professor, Institute of Pharmacology and Toxicology, Tzu Chi Univ, Taiwan
1998-2001
Postdoctoral Fellow, Institute of Biomedical Sciences, Academia Sinica, Taiwan
1998
Ph.D. Institute of Life Sciences, National Defense Medical Center, Taiwan
研究方向展開收合

個體的增長與細胞有絲分裂息息相關，並仰賴功能精準的有絲分裂以正確的將遺傳訊息傳遞給子細胞。當參與細胞分裂的組件被破壞而使有絲分裂無法順利進行時，會導致有絲分裂期細胞死亡，因而能降低子細胞發生基因組異常的機會，避免疾病發生。但癌細胞常發生中心體倍增或紡錘體失常而致使有絲分裂異常，為使有絲分裂能順利完成和細胞增殖，癌細胞必須設法減弱有絲分裂期細胞死亡，這常造成癌細胞的進一步惡化、復發或抗藥性。因此如何控制有絲分裂期細胞死亡是癌症發生或治療的關鍵。

我們利用培養的細胞以細胞生物學方法，系統性的解構有絲分裂期的細胞如何因應不利環境而得以存活的細胞和分子機制。希望透過這些研究能進一步了解癌症發生的關鍵和可能的治療標的。 

代表著作展開收合
  1. Kuo HH, Su ZR, Chuang JY, and Yih LH*. Heat shock factor 1 suppression induces spindle abnormalities and sensitizes cells to antimitotic drugs. Cell Division. 16(1):8. 
  2. Fang CT, Kuo HH, Yuan CJ, Yao JS, and Yih LH*. Mdivi-1 induces spindle abnormalities and augments taxol cytotoxicity in MDA-MB-231 cells. Cell Death Discovery. 7(1):118. 2021.
  3. Fang CT, Kuo HH, Hsu SC, and Yih LH*. HSP70 regulates Eg5 distribution within the mitotic spindle and modulates the cytotoxicity of Eg5 inhibitors. Cell Death & Disease. 11(8):715. 2020.
  4. Lin TC, Kuo HH, Wu YC, Pan TS, and Yih LH*. Phosphatidylinositol-5-phosphate 4-kinase gamma accumulates at the spindle pole and prevents microtubule depolymerization. Cell Division. 14(9). 2019. 
  5. Fang CT, Kuo HH, Hsu SC, and Yih LH*. HSP70 is required for the proper assembly of pericentriolar material and function of mitotic centrosomes. Cell Division. 14(4). 2019. 
  6. Fang CT, Kuo HH, Pan TS, Yu FC, and Yih LH*. HSP70 regulates the function of mitotic centrosomes. Cell Mol Life Sci. 73(20):3949-60. 2016. 
  7. Kuo HH, Kakadiya R, Wu YC, Chuang CY, Su TL, TC Lee, YW Lin, and Yih LH*. Derivatives of 6-cinnamamido-quinoline-4-carboxamide impair lysosome function and induce apoptosis. Oncotarget. 7(25):38078-38090. 2016. 
  8. Liou JS, Wu YC, Yen WY, Tang YS, Kakadiya RB, Su TL, and Yih LH*. Inhibition of autophagy enhances DNA damage-induced apoptosis by disrupting CHK1-dependent S phase arrest. Toxicol Appl Pharmacol. 278(3):249-58. 2014. 
  9. Chen YJ, Lai KC, Kuo HH, Chow LP, Yih LH*, and Lee TC*. HSP70 colocalizes with PLK1 at the centrosome and disturbs spindle dynamics in cells arrested in mitosis by arsenic trioxide. Arch Toxicol. 88(9):1711-23. 2014. (Co-corresponding) 
  10. Yih LH*, Hsu NC, Wu YC, Yen WY, and Kuo HH. Inhibition of AKT enhances mitotic cell apoptosis induced by arsenic trioxide. Toxicol Appl Pharmacol. 267(3):228-37. 2013.