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研究人員｜中央研究院 細胞與個體生物學研究所

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側邊選單開關 研究人員
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  • 周雅惠Ya-Hui Chou 周雅惠老師 Research ID 周雅惠老師 ORCID
    副研究員Associate Research Fellow
    • 專長：Developmental Neurobiology, Neuronal circuitry, Insect Behavior
    • 信箱：yhchou@gate.sinica.edu.tw
    • 電話：02-2789-9540
    • 網站： 神經迴路及行為實驗室
    • 位置：R202/ICOB
友善列印
經歷簡介展開收合
2019-
Associate Research Fellow, Institute of Cellular and Organismic Biology, Academia Sinica, Taiwan
2011-2019
Assistant Research Fellow, Institute of Cellular and Organismic Biology, Academia Sinica, Taiwan
2004-2011
Postdoctoral Research Fellow, Department of Biology, Stanford University, USA
2003-2004
Postdoctoral Research Fellow, Institute of Molecular Biology, Academia Sinica, Taiwan
2003
PhD. Institute of Molecular Biology, Academia Sinica and Institute of Life Science, National Defense Medical Center, Taiwan
研究方向展開收合

雖然每個人的大腦都經由相同的發育機轉而架構、成熟，當面對相同的環境刺激，每個個體接收訊息的程度並不會完全相同，而這種差異最終會反映在我們對周遭環境的判讀及行為反應。我們實驗室即對神經差異性 (Neuronal variability) 的形成及其對個體行為的影響有興趣。

　　果蠅嗅覺神經系統的區域中介神經元具有相當複雜的多樣性 (Diversity) 及差異性 (Variability)，但我們對於這些細胞如何在發育過程中及個體成熟後達到其多樣性及差異性幾乎一無所知。在過去幾年，我們實驗室先建立了果蠅嗅覺區域中介神經元的標定工具及其發育圖譜，並建立了數套結合數學運算及機器學習的果蠅行為偵測系統。目前正經由系統性地研究區域中介神經元的發育、其如何選擇與特定的嗅覺神經元及二級神經元形成獨特的連結、神經訊號在迴路之間的動態傳遞以及其差異性對個體行為的影響，來瞭解不同個體大腦中神經迴路的差異性是如何造成的，以及其如何影響我們對外界環境的判讀。

代表著作展開收合
1
Tsai, K.T., Chou, Y.H.* (2022) Drosophila as a model to explore individuality. Behavioral Neurogenetics. Daisuke Yamamoto Editor. Humana Press, Springer Science. (Invited book chapter) (In press)
2
Chou, Y.H.*, Yang, C.J., Huang, H.W., Liou, N.F., Panganiban, M.R., Luginbuhl, D., Yin, Y., Taisz, I., Liang, L., Jefferis, G.S.X.E., Luo, L. (2022) Mating-driven Variability in Olfactory Local Interneuron Wiring. Science Advances. 8, eabm7723. DOI: 10.1126/sciadv.abm7723
3
Tsai, K.T., Chou, Y.H.* (2019) Random walk revisited: quantification and comparative analysis of Drosophila walking trajectories. iScience 19, 1145-1159. (DOI: 10.1016/j.isci.2019.08.054) 
4
Chen, Y.J., Chang, H.H., Lin, S.H., Lin, T.Y., Wu, T.H., Lin, H.J., Liou, N.F., Yang, C.J., Chen, Y.T., Chang, K.H., Li, C.Y., Chou, Y.H.* (2019) Differential efficacy of genetically swapping GAL4. J. Neurogenetics 33, 52-63. (DOI: 10.1080/01677063.2018.1564289)
5

Liou, N.F.#, Lin, S.H.#, Chen, Y.J.#, Tsai, K.T.&, Yang, C.J.&, Lin, T.Y., Wu, T.H., Lin, H.J., Chen, Y.T., Gohl, D.M., Silies, M., Chou, Y.H.* (2018) Diverse populations of local interneurons integrate into the Drosophila adult olfactory circuit. Nature Communications9, 2232. DOI:10.1038/s41467-018-04675-x

Recommended by F1000Prime. Hiesinger P:F1000Prime, 10.3410 (Dec. 2018) 10.3410/f.733424303.793554440

6
Tsai, K.T., Hu, C.K., Li, K.W., Hwang, W.L., Chou, Y.H.* (2018) Circuit variability interacts with excitatory-inhibitory diversity of interneurons to regulate network encoding capacity. Scientific Reports 8, 8027. (DOI: 10.1038/s41598-018-26286-8>
7
Wu, B., Li J., Chou, Y.H., Luginbuhl D., and Luo L. (2017) Fibroblast growth factor signaling instructs ensheathing glia warpping of Drosophila olfactory glomeruli. PNAS 114, 7505-7512. DOI:10.1073/pnas.1706533114
8
Sweeney, L.B., Chou, Y.H.#, Wu, Z.#, Joo W.#, Komiyama, T., Potter, C.J., Kolodkin, A., Garcia, K.C., and Luo, L. (2011) Secreted Semaphorins from degenerating larval ORN axons direct adult projection neuron dendrite targeting. Neuron 72, 734-747. DOI:10.1016/j.neuron.2011.09.026
9

Chou, Y.H., Zheng, X., Beachy, P.A. and Luo, L.* (2010) Patterning axon targeting of olfactory receptor neurons by coupled Hedgehog signaling at two distinct steps. Cell 142, 954-966. (DOI: 10.1016/j.cell.2010.08.015)

(Featured in Nature Reviews Neuroscience, Research Highlights. (Nov. 2010))

10

Chou, Y.H.‡, Spletter, M.L.‡, Yaksi, E.‡, Leong, J.C.S., Wilson, R.I.* and Luo, L.* (2010) Diversity and wiring variability of olfactory local interneurons in the Drosophila antennal lobe. Nature Neuroscience 13, 439-449. (DOI: 10.1038/nn.2489)

(Featured on the cover)