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研究人員｜中央研究院 細胞與個體生物學研究所

研究人員
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側邊選單開關 研究人員
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文章內容區

  • 吳金洌Jen-Leih Wu
    客座講座Distinguished Visiting Fellow
    • 專長：Molecular Biology, Molecular Virology, Developmental Biolog
    • 信箱：jlwu@gate.sinica.edu.tw
    • 電話：02-2789-9568
    • 網站： 吳金洌老師實驗室
    • 位置：R302/ICOB
友善列印
經歷簡介展開收合
2005-
Co-Chairman, National Science and Technology Program for Agricultural Biotechnology, NSC
2002-2004
Adviser-Life Science and Biotechnology, Ministry of Education, Taiwan
1997-2001
Executive Secretary, Central Advisory Committee, Academia Sinica, Taiwan
1988
Professor (Adjunct), National Taiwan University, National Cheng Kung University, Taiwan
1984-1996
Director、Deputy Director, Institute of Zoology, Academia Sinica, Taiwan
1978
Visiting Scholar at National Institute of Health; 1984, Johns Hopkin Univ.; 1985, Harvard Univ., USA
1975
Ph.D. University of Arkansas, USA
代表著作展開收合

  1. Rekha, R.D., Amali, A.A., Her, G.M., Yeh, Y.H., Gong, H.Y., Hu, S.Y., Lin, G.H. and Wu, J.L.* (2008) Thioacetamide accelerate steatohepatitis, cirrhosis and HCC by expressing HCV core protein in transgenic zebrafish Danio rerio. Toxicology, 243 : 11 - 22.

  2. Lu, M.W., Chao, Y.M., Guo, T.C., Santi, N., Evensen, Ø., Kasani, S.K., Hong, J.R. and Wu, J.L.* (2008) The interferon response is involved in nervous necrosis virus acute and persistent infection in zebrafish infection model. Molecular Immunology, 45 : 1146 - 1152.

  3. Lin, C.J.F., Gong, H.Y., Tseng, H.C., Wang, W.L. and Wu, J.L.* (2008) miR-122 targets an anti-apoptotic gene, Bcl-w, in human hepatocellular carcinoma cell lines. Biochemica l and Biophysical Research Communications, 375 : 315 - 320.

  4. Hu, S.Y., Lin, P.Y., Liao, C.H., Gong, H.Y., Lin, G.H., Kawakami, K. and Wu, J.L.* (2010) Nitroreductase-mediated gonadal dysgenesis for infertile control of genetically modified zebrafish. Marine Biotechnology, 12 : 569 - 578.

  5. Li, Y.H., Chen, H.C., Hu, S.Y., Li, Y.W., Lin, G.H., Lin, C.C., Gong, H.Y., Liu, W. and Wu, J.L.* (2010) Progranulin A-mediated MET signaling is essential for liver morphogenesis in zebrafish. Journal of Biological Chemistry, 285 : 41001 - 41009.

  6. Hu, S.Y., Liao, C.H., Lin, Y.P., Li, Y.H., Gong, H.Y., Lin, G.H., Kawakami, K., Yang, T.H. and Wu, J.L.* (2011) Zebrafish eggs used as bioreactors for the production of bioactive tilapia insulin-like growth factors.Transgenic Research, 20 : 73 - 83.

  7. Wang, W.L., Hong, J.R., Lin, G.H., Liu, W., Gong, H.Y., Lu, M.W., Lin, C.C. and  Wu, J.L.* (2011) Stage-Specific expression of TNFα regulates Bad/Bid mediated apoptosis and  RIP1/ROS-mediated secondary necrosis in birnavirus-infected fish cells. PLoS ONE, 6 : e16740.

  8. Wang, W.L., Liu, W., Gong, H.Y., Hong, J.R., Lin, C.C. and Wu, J.L.* (2011)  Activation of cytokines expression occurs through the TNFα/NF-κB-mediated pathway inbirnavirus infected cells. Fish and Shellfish Immunology, 31 : 10 – 21.

  9. Hu, S.Y., Tai, C.C., Li, Y.H. and Wu, J.L.* (2012) Progranulin compensates for blocked IGF-1 signaling to promote myotube 3 hypertrophy in C2C12 myoblasts via the PI3K/Akt/mTOR pathway. FEBS Letters, 586 : 3485 – 3492.

  10. Liu, W., Chen, J.R.,  Hsu, C.H.,  Li, Y.S.,  Chen, Y.M.,  Lin, C.Y.,  Huang, S.J.,  Chang, Z.K., Chen, Y.C.,  Lin, C.H.,  Gong, H.Y.,  Lin, C.C.,  Kawakami, K. and Wu, J.L.* (2012) A zebrafish model of intrahepatic cholangiocarcinoma by dual expression of hepatitis B virus X and hepatitis C virus core protein in liver. Hepatology, 56 : 2268 – 2278.