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研究人員｜中央研究院 細胞與個體生物學研究所

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側邊選單開關 研究人員
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  • 游宏祥Hung-Hsiang Yu
    副研究員Associate Research Fellow
友善列印
經歷簡介展開收合
2019-present
Associate Research Fellow, Institute of Cellular and Organismic Biology, Academia Sinica, Taiwan.
2011-2019
Assistant Research Fellow, Institute of Cellular and Organismic Biology, Academia Sinica, Taiwan.
2008-2011
Research Specialist, Janelia Farm Research Campus, Howard Hughes Medical Institute, USA.
2005-2008
Postdoctoral Fellow, Department of Neurobiology, University of Massachusetts Medical School, USA.
2000-2005
Postdoctoral Fellow, Division of Basic Sciences, Fred Hutchinson Cancer Research Center, USA.
2000
Ph.D., Department of Neuroscience, Johns Hopkins University School of Medicine, USA.
研究方向展開收合

動物利用散佈在周遭環境的味道來尋找食物，躲避敵人和挑選伴侶。因此發育過程中，建構正確的嗅覺神經網路，對動物的生存極其重要。在果蠅嗅覺神經網路內，同類的嗅覺感覺神經元(olfactory sensory neuron/OSNs)偵測到嗅覺分子後，將訊號經傳入大腦嗅葉(antennal lobe/AL)上的單一嗅球(glomerulus)，再由嗅覺投射神經元(projection neuron/PNs)傳到大腦的蘑菇體(mushroom body)及側角組織(lateral horn)(圖一)。我們實驗室研究嗅覺投射神經元及蘑菇體神經元在發育過程中，是如何建構嗅覺神經網路。我們發現，穿膜蛋白Semaphorin-1a (Sema-1a)對建構果蠅成蟲具有功能的嗅覺神經網路，有著不可或缺的角色(圖二)。我們將進一步研究與Sema-1a相關的細胞及分子機制，是如何來調控此精確的嗅覺圖譜的建構。另外，我們也將研究在細胞及分子層次上，蘑菇體神經元的命運特化及大範圍的軸突修剪是如何被正確調控，以建構果蠅成蟲大腦中具有功能性的嗅覺神經網路，此對動物的生存亦扮演著至關重要的角色(圖三)。

代表著作展開收合
  1. Lai, Y.W., Miyares, R.L., Liu, L.Y., Chu, S.Y., Lee, T. and Yu, H.H. (2022). Hormone-controlled changes in the differentiation state of post-mitotic neurons. Current Biology 32, 1-8. doi: 10.1016/j.cub.2022.04.027.
  2. Wei, J.Y., Chu, S.Y., Hung, Y.C., Chung, P.C. and Yu, H.H. (2022). Drosophila septin interacting protein 1 regulates neurogenesis in the early developing larval brain. Scientific Reports, 12 (1): 292. doi: 10.1038/s41598-021-04474-3.
  3. Lin, T.Y., Chen, J.P., Yu, H.H., Hsu C.P. and Lee, C.H. (2021). Extrinsic factors regulating dendritic patterning. Front. Cell. Neuroscience, 14, 622808. doi: 10.3389/fncel.2020.622808
  4. Garcia-Marques, J., Espinosa-Medina, I., Ku, K.Y., Yang, C.P., Koyama, M., Yu, H.H. and Lee, T. (2020).  A programmable sequence of reporters for lineage analysis. Nature Neuroscience, 23: 1618-1628. doi: 10.1038/s41593-020-0676-9.
  5. Lai, Y.W., Chu, S.Y., Li, J.C., Chen, P.L., Chen, C.H. and Yu, H.H. (2020).  Visualization of Endogenous Type I TGF-β Receptor Baboon in the Drosophila Brain. Scientific Reports 10 (1): 5153. doi: 10.1038/s41598-020-61950-y.
  6. Hsu, T.C., Ku, K.Y., Shen, H.C. and Yu, H.H. (2020). Overview of MARCM-related technologies in Drosophila neurobiological research. Current Protocols in Neuroscience, 91, e90. doi: 10.1002/cpns.90.
  7. Wei, J.Y., Chung, P.C., Chu, S.Y., and Yu, H.H. (2019). FOXO Regulates Cell Fate Specification of Drosophila Ventral Olfactory Projection Neurons. Journal of Neurogenetics, 33(1): 33-40.  doi: 10.1080/01677063.2018.1556651.
  8. Shen, H.C., Chu, S.Y., Hsu, T.C., Wang, C.H., Lin, I.Y. and Yu, H.H. (2017). Semaphorin-1a Prevents Drosophila Olfactory Projection Neuron Dendrites from Mis-targeting into Select Antennal Lobe Regions. PLOS Genetics 13(4): e1006751. doi: 10.1371/journal.pgen.1006751. 
  9. Lai, Y.W., Chu, S.Y., Wei, J.Y., Cheng, C.Y., Li, J.C., Chen, P.L., Chen, C.H. and Yu, H.H. (2016). Drosophila microRNA-34 Impairs Axon Pruning of Mushroom Body γ Neurons by Downregulating the Expression of Ecdysone Receptor. Scientific Reports 6: 39141. doi: 10.1038/srep39141.
  10. Shen, H.C., Wei, J.Y., Chu, S.Y., Chung, P.C., Hsu, T.C. and Yu, H.H. (2016). Morphogenetic Studies of the Drosophila DA1 Ventral Olfactory Projection Neuron. PLOS One 11 (5): e0155384. doi: 10.1371/journal.pone.0155384.