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研究人員|中央研究院 細胞與個體生物學研究所

研究人員
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側邊選單開關 研究人員
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文章內容區

  • 高承福Cheng-Fu Kao
    研究員Research Fellow
    • 專長:Chromatin Structure & Dynamics, DNA Replication and Repair
    • 信箱:ckao@gate.sinica.edu.tw
    • 電話:02-2787-1515
    • 網站: 高承福老師實驗室
    • 位置:R243/ICOB
經歷簡介展開收合
2020-
Research fellow, Institute of Cellular and Organismic Biology, Academia Sinica
2015-2020
Associate research fellow, Institute of Cellular and Organismic Biology, Academia Sinica
2006- 2015
Assistant research fellow, Institute of Cellular and Organismic Biology, Academia Sinica
2005- 2006
Research Faculty, Dept. of Molecular and Microbiology, University of New Mexico
2002- 2005
Postdoctoral Research Fellow, Dept. of Molecular and Microbiology, University of New Mexico
2002
University of Edinburgh Ph. D, Biochemistry
研究方向展開收合

• 染色質構造及功能

• 染色質動態與表觀遺傳學的代謝機制研究

• 染色質調節機制對發育及疾病的影響

本實驗室的研究集中在染色質的構造及其對細胞體分子功能機制的影響。染色質中核小體(nucleosomes)的分布密度及位置是基因組開始啟動複製的關鍵原因之一,而這也是細胞分裂的重要過程,將影響細胞的命運。同時,染色質的構造亦影響基因的活化及抑制,而這樣的過程會影響細胞週期以及DNA損傷修復。

在調節染色質的角色中,有一群重要的分子,稱做組蛋白轉譯前修飾因子(histone post-translational modifications, PTMs)。這些PTMs訊息間的溝通協調會讓染色質維持在一個平衡狀態,以利細胞維持正常生理功能。DNA模版在複製起始過程中,這些修飾因子有可能透過標記的「寫入」、「讀取」或是「擦除」而引發複製錯誤,這樣的錯誤造成發育上的疾病或腫瘤就一點都不意外了!甚至在一些癌症的研究中也曾指出,這些組蛋白的修飾因子也在癌細胞的發展進程中改變,因此研究修飾因子的調控及如何決定細胞命運,是我們非常感興趣的主題!

代表著作展開收合
  1. Lin CY, Chang YM, Tseng HY, Shih YL, Yeh HH, Chen PL, Chen CC, Yan YT*, and Kao CF*. Chromatin state transition underlies the temporal changes in gene expression during cardiomyocyte maturation. bioRxiv 2021.12.28.474318.
  2. Huang JH, Liao YR, Lin TC, Tsai CH, Lai WY, Chou YK, Leu JY, Tsai HK*, Kao CF*. iTARGEX analysis of yeast deletome reveals novel regulators of transcriptional buffering in S phase and protein turnover. Nucleic Acids Res. 2021 Jul 21;49(13):7318-7329. doi: 10.1093/nar/gkab555. 
  3. Hsu CL, Chong SY, Lin CY, Kao CF*. Histone dynamics during DNA replication stress. J Biomed Sci. 2021 Jun 19;28(1):48. doi: 10.1186/s12929-021-00743-5. 
  4. Chang CY, Hung JH, Huang LW, Li J, Fung KS, Kao CF, Chen L. Epigenetic Regulation of WNT3A Enhancer during Regeneration of Injured Cortical Neurons. Int J Mol Sci. 2020 Mar 10;21(5). pii: E1891. doi: 10.3390/ijms21051891.
  5. Chang CY, Liang MZ, Wu CC, Huang PY, Chen HI, Yet SF, Tsai JW, Kao CF*, Chen L*. WNT3A Promotes Neuronal Regeneration upon Traumatic Brain Injury. Int J Mol Sci. 2020 Feb 21;21(4). pii: E1463. doi: 10.3390/ijms21041463. 
  6. Chong SY, Cutler S, Lin JJ, Tsai CH, Tsai HK, Biggins S, Tsukiyama T, Lo YC and Kao CF*. H3K4 methylation at active genes mitigates transcription-replication conflicts during replication stress. Nat Commun. 2020 Feb 10;11(1):809. doi: 10.1038/s41467-020-14595-4. 
  7. You ST, Jhou YT, Kao CF, Leu JY. Experimental evolution reveals a general role for the methyltransferase Hmt1 in noise buffering. PLoS Biol. 2019 Oct 15;17(10):e3000433. .
  8. Wu MY, Lin CY, Tseng HY, Hsu FM, Chen PY and Kao CF*. H2B ubiquitylation and the Asf1 histone chaperone mediate the formation and maintenance of heterochromatin architecture. Nucleic Acids Res. 2017 May 17. doi: 10.1093/nar/gkx422. (*correspondent author) 
  9. Hung SH, Wong RP, Ulrich HD* and Kao CF*. Bre1-mediated mono-ubiquitylation of H2B contributes to the bypass of DNA damage during and after DNA replication Proc Natl Acad Sci U S A. 2017 Mar 14;114(11):E2205-E2214. (*correspondent authors) (
  10. Chen KW, Chang YJ, Yeh CM, Lian YL, Chan MW, Kao CF* and Chen L. SH2B1 modulates chromatin state and MyoD occupancy to enhance expressions of myogenic genes. Biochim Biophys Acta. 2017 Feb;1860(2):270-281.