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研究人員｜中央研究院 細胞與個體生物學研究所

研究人員
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側邊選單開關 研究人員
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  • 廖永豐Yung-Feng Liao
    研究員Research Fellow
友善列印
經歷簡介展開收合
2021-
Research Fellow, Institute of Cellular and Organismic Biology, Academia
2009-2021
Associate Research Fellow, Institute of Cellular and Organismic Biology, Academia
2005-2009
Assistant Research Fellow, Institute of Cellular and Organismic Biology, Academia Sinica, Taipei, Taiwan.
2002-2005
Assistant Research Fellow, Institute of Zoology, Academia Sinica, Taipei, Taiwan.
2001-2002
Postdoctoral Research Fellow, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, USA
1998-2001
Postdoctoral Research Fellow, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
1998
Ph.D., Dept. of Biochemistry and Molecular Biology, University of Georgia, Athens, GA, USA.
2013-
Adjunct Associate Professor, Department of Life Science, National Taiwan University.
2004-2013
Adjunct Assist./Assoc. Professor, Institute of Zoology, National Taiwan University.
研究方向展開收合

1. gamma-Secretase酵素活性的分子調控與阿滋海默氏症（Alzheimer's Disease）致病機制之相關性，並應用於開發新穎且副作用低的阿滋海默氏症新藥。

2. 神經母細胞瘤（Neuroblastoma）之癌化反應機轉及神經細胞分化之分子調控機制，以利發展神經母細胞瘤的標靶治療新藥及個人化醫療之新方向。

代表著作展開收合
  1. N. Bhore, B.-J. Wang, P.-F. Wu, Y.-L. Lee, Y.-W. Chen, W.- M. Hsu, H. Lee, Y.-S. Huang, D.-I Yang, and Y.-F. Liao*. (2021) Dual-specificity phosphatase 15 (DUSP15) modulates Notch signaling by enhancing the stability of Notch protein. Mol. Neurobiol., 58: 2204-2214.
  2. P.-F. Wu, N. Bhore, Y.-L. Lee, J.-Y. Chou, Y.-W. Chen, P.-Y. Wu, W.-M. Hsu, H. Lee, Y.-S. Huang, P.-J. Lu, Y.-F. Liao*. (2020) Phosphatidylinositol-4-Phosphate 5-Kinase Type 1α Attenuates Aβ Production by Promoting Non-amyloidogenic Processing of Amyloid Precursor Protein. FASEB J., 34: 12127-12146. 
  3. P.-Y. Wu, I-S. Yu, Y.-C. Lin, Y.-T. Chang, C.-C. Chen, K.-H. Lin, T.-H. Tseng, M. Kargren, Y.-L. Tai, T.-L. Shen, Y.-L. Liu, B.-J. Wang, C.-H. Chang, W.-M. Chen, H.-F. Juan, S.-F. Huang, Y.-Y. Chan, Y.-F. Liao*, W.-M. Hsu*, and H. Lee*. (2019) Activation of Aryl Hydrocarbon Receptor by Kynurenine Impairs Progression and Metastasis of Neuroblastoma. Cancer Res., 79: 5550-5562. 
  4. P.-Y. Wu, P.-Y. Chuang, G.-D. Chang, Y.-Y. Chan, T.-C. Tsai, B.-J. Wang, K.-H. Lin, W.-M. Hsu*, Y.-F. Liao*, and H. Lee*. (2019) Novel Endogenous Ligands of Aryl Hydrocarbon Receptor Mediate Neural Development and Differentiation of Neuroblastoma. ACS Chem. Neurosci., 10: 4031-4042. 
  5. B.-J. Wang, G. M. Her, M.-K. Hu, Y.-W. Chen, Y.-T. Tung, P.-Y. Wu, W.-M. Hsu, H. Lee, L.-W. Jin, S.-P. L. Hwang, R. P.-Y. Chen, C.-J. Huang, and Y.-F. Liao*. (2017) ErbB2 regulates autophagic flux to modulate the proteostasis of APP-CTFs in Alzheimer's disease. Proc. Natl. Acad. Sci. U.S.A., 114: E3129-E3138. 
  6. Y.-T. Tung, B.-J. Wang, W.-M. Hsu, M.-K. Hu, G. M. Her, W.-P. Huang*, Y.-F. Liao*. (2014) Presenilin-1 regulates the expression of p62 to govern p62-dependent Tau degradation. Mol. Neurobiol., 49, 10-27. 
  7. A. Kapoor, B.-J. Wang, W.-M. Hsu, M.-Y. Chang, S.-M. Liang*, Y.-F. Liao*. (2013) Retinoic acid-elicited RARα/RXRα signaling attenuates Aβ production by directly inhibiting γ-secretase-mediated cleavage of amyloid precursor protein. ACS Chem. Neurosci., 4, 1093-1100. 
  8. H.-H. Chang, H. Lee, M.-K. Hu, P.-N. Tsao, H.-F. Juan, M.-C. Huang, Y.-Y. Shih, B.-J. Wang, Y.-M. Jeng, C. L. Chang, S.-F. Huang, Y.-G. Tsay, F.-J. Hsieh, K.-H. Lin*, W.-M. Hsu*, and Y.-F. Liao*. (2010) Notch1 expression predicts an unfavorable prognosis and serves as a therapeutic target of patients with neuroblastoma. Clin. Cancer Res., 16, 4411-4420. (Highlights: Selected articles from this issue by editors) 
  9. L.-H. Kuo, M.-K. Hu, W.-M. Hsu, Y.-T. Tung, B.-J. Wang, W.-W. Tsai, C.-T. Yen, and Y.-F. Liao*. (2008) TNF-α-elicited stimulation of γ-secretase is mediated by JNK-dependent phosphorylation of presenilin and nicastrin. Mol. Biol. Cell, 19, 4201-4212.  
  10. Y.-F. Liao*, Wang, B.-J., Cheng, H.-T., Kuo, L.-H., Wolfe, M. S. (2004) TNF-α, IL-1β, and IFN-γ stimulate γ-secretase-mediated cleavage of amyloid precursor protein through a JNK-dependent MAPK pathway. J. Biol. Chem. 279, 49523-49532.